P30 Atorvastatin Reduces Macrophage Accumulation in the Atherosclerotic Plaque in Patients Undergoing Carotid Endarterectomy: A Comparison Versus Non-Statin Based Regimen

Nanoparticles in endothelial theranostics

“…A significant decrease of activated macrophage content within the atherosclerotic plaques of the group treated with atorvastatin compared with the untreated one was observed [36]. That corresponded well with the earlier observation on the role of atorvastatin on high-cholesterol-diet-induced atherosclerosis in humans and monitored using histological procedures [37]. The therapeutic approach proposed for high-risk patients is to stabilize atherosclerotic lesions by inducing regression.…”

Regression of coronary atherosclerosis: Current evidence and future perspectives

“…Consistently, the IBIS-4 study showed stabilization but no decrease of necrotic core size in patients with STEMI [8]. These observations are somewhat discordant with the efficacy of statins for induction of (even modest) plaque volume reduction and for induction of non-coronary plaque stabilization in human histopathological studies [48]. The discordance might be explained by the satisfactory [16][17][18] yet likely imperfect correlation between IVUS-VH and histology or alternatively, by inadequate power in all of the above mentioned studies.…”

Carotid atherosclerotic plaque stenosis: the stabilizing role of statins

“…The direct effects of statins on stabilization of human carotid plaques were also investigated . We recently showed that an ongoing statin treatment might be associated with reduction in the systemic activation of the receptor activator of NF‐kB ligand (RANKL)/osteoprotegerin (OPG) system in patients with severe carotid stenosis and asymptomatic for ischaemic stroke .…”