P300 and the thought disorder factor extracted by factor-analytic procedures in schizophrenia

Higashima, Masato; Urata, Katsumi; Kawasaki, Yasuhiro; Matsuo, Yoshiki; Sakai, Naoto; Mizukoshi, Chikako; Nagasawa, Tatsuya; Kamiya, Takahiro; Yamaguchi, Nariyoshi; Koshino, Yoshifumi

doi:10.1016/s0006-3223(97)00359-4

Cited by 62 publications

(22 citation statements)

References 16 publications

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“…Furthermore, it has been reported that schizophrenic thought disorder is highly correlated with reduced volumes in the left posterior superior temporal gyrus (Shenton et al, 1992) and with decreased P300 amplitude (Higashima et al, 1998). From these findings, it is possible that, in schizophrenia, P300 abnormality, impaired verbal learning, and clinically observed thought disorder originate from a common pathology of the left posterior superior temporal gyrus.…”

Section: Discussionmentioning

confidence: 93%

The relationship between auditory ERP and neuropsychological assessments in schizophrenia☆

Nagasawa¹,

Kamiya²,

Kawasaki³

et al. 1999

International Journal of Psychophysiology

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To clarify the cognitive significance of event-related potential (ERP) abnormalities in schizophrenia, we examined the relationships of amplitudes and latencies of ERP components with performance on neuropsyhological tests in schizophrenic patients. Twenty patients underwent the Trail Making B Test (TM-B), which is sensitive to frontal lobe dysfunction, and the logical memory, verbal paired-association, and visual reproduction subtests of the Wechsler Memory Scale (WMS), which are sensitive to temporal lobe dysfunctions, and ERP recordings during performance of an oddball auditory discrimination task. Pearson product-moment correlations indicated that an increased P200 amplitude was correlated with poor performance on the TM-B, whereas a decreased P300 amplitude was correlated with poor performance on the verbal paired-association subtest of the WMS. These findings suggest that a P200 abnormality represents the frontal lobe dysfunction, and a P300 abnormality represents the left temporal lobe dysfunction in schizophrenia.

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Section: Discussionmentioning

confidence: 93%

The relationship between auditory ERP and neuropsychological assessments in schizophrenia☆

Nagasawa¹,

Kamiya²,

Kawasaki³

et al. 1999

International Journal of Psychophysiology

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“…Although the reduction in P300 amplitude is a robust finding in schizophrenia, the relationship between clinical variables and P300 deficits is mixed. Some but not other studies have found correlations between clinical symptoms and the auditory P300 (Blackwood et al, 1987;Egan et al, 1994;Higashima et al, 1998;Kawasaki et al, 1994;Mathalon et al, 2000;Merrin and Floyd, 1994;Saitoh et al, 1984;St Clair et al, 1989). Finally, the neural substrates governing the behavioral vs psychophysiological effects of cannabinoids may differ, thus accounting for the general absence of association between the behavioral changes and P300 deficits induced by THC.…”

Section: Relationship To Behavior and Impact Of Cannabis Exposurementioning

confidence: 98%

Dose-Related Modulation of Event-Related Potentials to Novel and Target Stimuli by Intravenous Δ9-THC in Humans

D’Souza

Fridberg

Skosnik

et al. 2012

Neuropsychopharmacol

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Cannabinoids induce a host of perceptual alterations and cognitive deficits in humans. However, the neural correlates of these deficits have remained elusive. The current study examined the acute, dose-related effects of delta-9-tetrahydrocannabinol (D 9 -THC) on psychophysiological indices of information processing in humans. Healthy subjects (n ¼ 26) completed three test days during which they received intravenous D 9 -THC (placebo, 0.015 and 0.03 mg/kg) in a within-subject, double-blind, randomized, cross-over, and counterbalanced design. Psychophysiological data (electroencephalography) were collected before and after drug administration while subjects engaged in an event-related potential (ERP) task known to be a valid index of attention and cognition (a three-stimulus auditory 'oddball' P300 task). -THC-induced perceptual alterations. Lastly, exploratory analyses examining cannabis use status showed that whereas recent cannabis users had blunted behavioral effects to D 9 -THC, there were no dose-related effects of D 9 -THC on P300a/b amplitude between cannabis-free and recent cannabis users. Overall, these data suggest that at doses that produce behavioral and subjective effects consistent with the known properties of cannabis, D 9-THC reduced P300a and P300b amplitudes without altering the latency of these ERPs. Cannabinoid agonists may therefore disrupt cortical processes responsible for context updating and the automatic orientation of attention, while leaving processing speed and earlier sensory ERP components intact. Collectively, the findings suggest that CB1R systems modulate top-down and bottom-up processing.

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“…In these six studies, the five components were generally interpreted as a positive, negative, cognitive (disorganised), excited (hostility) and depression component. Except for the studies of Kawasaki et al (1994) (mean age=26 years) and Higashima et al (1998) (mean age=25.8 years), the mean age of patients in all studies was above 30 years with an overall age range between 16 and 68 years. Because the sample size in these studies was limited (n=70; Kawasaki et al 1994;n=73;Higashima et al 1998), additional analyses are needed of the PANSS component structure in young patients.…”

Section: Introductionmentioning

confidence: 95%

“…Peralta and Cuesta (1994) found eight components, Kay and Sevy (1990) found seven components, and Bassett et al (1994) found three components. The other six studies found five components (Bell et al 1994;Kawasaki et al 1994;Lindenmayer et al 1994Lindenmayer et al , 1995Marder et al 1997;Higashima et al 1998). In these six studies, the five components were generally interpreted as a positive, negative, cognitive (disorganised), excited (hostility) and depression component.…”

Section: Introductionmentioning

confidence: 99%

Component structure of the Positive And Negative Syndrome Scale (PANSS) in patients with recent-onset schizophrenia and spectrum disorders

et al. 2000

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P300 and the thought disorder factor extracted by factor-analytic procedures in schizophrenia

Cited by 62 publications

References 16 publications

The relationship between auditory ERP and neuropsychological assessments in schizophrenia☆

The relationship between auditory ERP and neuropsychological assessments in schizophrenia☆

Dose-Related Modulation of Event-Related Potentials to Novel and Target Stimuli by Intravenous Δ9-THC in Humans

Component structure of the Positive And Negative Syndrome Scale (PANSS) in patients with recent-onset schizophrenia and spectrum disorders

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