P300 auditory event-related potentials in children with obesity: is childhood obesity related to impairment in cognitive functions?

Tascilar, Mehmet Emre; Türkkahraman, Doğa; Öz, Oğuzhan; Yücel, Mehmet; Taşkesen, Mustafa; Eker, İbrahim; Abacı, Ayhan; Dündaröz, Ruşen; Ulaş, Ümit Hıdır

doi:10.1111/j.1399-5448.2010.00748.x

Cited by 37 publications

(42 citation statements)

References 27 publications

(30 reference statements)

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“…Tascilar et al . 19 investigated electroencephalographic activity (latency and amplitude of P300 wave) using an auditory discriminated task paradigm ( n = 73) in 10-year-old children and found reduced amplitude in the obese group compared with the NW group. Furthermore, obese children with insulin resistance had lower P300 amplitude than obese children without insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

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Inhibitory control in otherwise healthy overweight 10-year-old children

et al. 2015

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BACKGROUND Preventing obesity is a worldwide public health priority. In vulnerable children living in obesogenic environments, with easy access to high-caloric food, alterations in inhibitory control functions might favor excessive food intake and affect energy regulation. We hypothesized that overweight/obese children would present lower inhibitory control in comparison to normal weight children. METHODS We measured inhibitory control functions in 93 otherwise healthy overweight/obese and 92 normal weight 10-year-old children using the Stroop test and the Go/No-Go task. Event-related potentials were recorded during the Go/No-Go task. RESULTS Overweight/obese children showed slower reaction times (1248.6 ms (95% confidence interval (CI): 1182.9–1314.3) vs 1149.0 ms (95% CI: 1083.0–1215.1)) on the Stroop test, higher reaction time variability (0.25 (95% CI: 0.22–0.27) vs 0.21 (95% CI: 0.19–0.24)) on the Go/No-Go task and decreased P300 amplitude (4.1 µV (95% CI: 3.0–5.2) vs 6.4 µV (95% CI: 5.2–7.6)) on event-related potentials compared with normal weight children. CONCLUSIONS Our results indicate altered inhibitory control functions in otherwise healthy overweight/obese children, which might contribute to their excessive food consumption.

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Section: Introductionmentioning

confidence: 99%

“…Furthermore, obese children with insulin resistance had lower P300 amplitude than obese children without insulin resistance. 19 …”

Section: Introductionmentioning

confidence: 99%

Inhibitory control in otherwise healthy overweight 10-year-old children

et al. 2015

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“…Neuroimaging research has mainly focused on brain function with only a single instance of brain structure reported. Specifically, event-related brain potential studies have uncovered differences in attention [15], inhibition [16], and conflict monitoring [17] during tasks that manipulate executive control, such that healthy-weight children exhibit larger and more effective patterns of neuroelectric activation relative to overweight/obese children. These findings were accompanied by differences in task performance, with healthy-weight children outperforming overweight/obese children, particularly on tasks that require greater amounts of executive control.…”

Section: Body Massmentioning

confidence: 99%

The Relationship of Health Behaviors to Childhood Cognition and Brain Health

Hillman

Khan²,

Kao

2015

Ann Nutr Metab

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Background: Physical activity and aerobic fitness have been shown to have positive implications for children's cognitive performance and brain structure and function. In addition, emerging evidence suggests that excess body mass is related to decreased cognitive performance and differential brain structure and function. Recently, several randomized controlled trials have provided causal evidence for the beneficial effects of daily physical activity on cognition and its neural underpinnings. However, the data linking excess body mass to compromised cognitive function are largely correlational since trials that manipulate body mass to determine changes in brain and cognition remain sparse. Such studies are sorely needed to provide strong evidence for the relation of childhood health behaviors to not only physical, but brain health as well. Summary: This manuscript provides a brief review of the current literature on physical activity and excess body mass on brain structure, brain function, and an aspect of cognition known as executive control, which refers to cognitive processes involved in the intentional component of environmental interaction. Generally, the findings indicate that daily physical activity or higher aerobic fitness is related to greater volume and integrity of brain structure, efficient and effective brain function, and superior executive control. Alternatively, excess body mass is related to decreased integrity of brain structure, less effective brain function, and poorer executive control. Key Messages: The findings have considerable implications for lifespan health and effective functioning, and demonstrate that childhood health behaviors have implications not only for cognitive and brain health but also for scholastic performance and educational attainment.

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“…Impaired response control and disrupted P3 responses during selective attention and response inhibition tasks are a common finding in the ADHD literature and in other syndromes characterized by poor behavior control and high levels of impulsivity, including childhood overweight/obesity (Bauer et al, 2010b; Tascilar et al, 2011). In a future study, it would be interesting to follow the present sample of college women over time and determine if the P3 and ANKK1 differences associated with weight gain during these early college years predict an overweight/obese body mass at a later time.…”

Section: Discussionmentioning

confidence: 99%

“…A second major goal was to examine the association of weight change with self-rated impulsivity and, in parallel, with an objective indicator of selective attention (Polich, 2007; Tascilar et al, 2011) and response inhibition (Bauer et al, 2010b; Ruchsow et al, 2008; Smith et al, 2013). The objective indicator was a highly reliable (Brunner et al, 2013), positive-going electroencephalographic response elicited by a stimulus requiring inhibition of a prepotent manual response—a so-called no-go P3 (Kamarajan et al, 2005; Smith et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Who gains? Genetic and neurophysiological correlates of BMI gain upon college entry in women

Bauer

2014

Appetite

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The present investigation examined P3 event-related electroencephalographic potentials and a short and selected list of addiction-related candidate gene single nucleotide polymorphisms (SNPs) within 84 female students, aged 18–20 yrs. The students were assigned to groups defined by the presence versus absence of a positive body mass index (BMI) change from the pre-college physical exam to the current day. Analyses revealed significantly greater P3 latencies and reduced P3 amplitudes during a response inhibition task among students who exhibited a BMI gain. BMI gain was also significantly associated with a ANKK1 SNP previously implicated in substance dependence risk. In logistic regression analyses, P3 latencies at the frontal electrode and this ANKK1 genotype correctly classified 71.1% of the students into the BMI groups. The present findings suggest that heritable indicators of impaired response inhibition can differentiate students who may be on a path toward an overweight or obese body mass.

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P300 auditory event-related potentials in children with obesity: is childhood obesity related to impairment in cognitive functions?

Cited by 37 publications

References 27 publications

Inhibitory control in otherwise healthy overweight 10-year-old children

Inhibitory control in otherwise healthy overweight 10-year-old children

The Relationship of Health Behaviors to Childhood Cognition and Brain Health

Who gains? Genetic and neurophysiological correlates of BMI gain upon college entry in women

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