P300 in major depressive disorder

Diner, Bradley C.; Holcomb, Philip J.; Dykman, Roscoe A.

doi:10.1016/0165-1781(85)90074-5

Cited by 122 publications

(61 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present investigation was performed in order to replicate the findings concerning different functional mechanisms underlying the reduced P300 in depressives and schizophrenics (Röschke et al, 1996c), which has been reported for the averaged signals in previous studies (Roth et al, 1980a(Roth et al, , b, 1981Brecher and Begleiter, 1983;Pfefferbaum et al, 1984;Diner et al, 1985;Blackwood et al, 1987;Gandaghar et al, 1993). In a former study, we reported the replication of a reduced number of 'true positive' P300 waves in schizophrenics (Wagner et al, 2000).…”

Section: Discussionsupporting

confidence: 74%

“…Especially for schizophrenics this could be confirmed in several investigations (Roth et al, 1980a, b;Brecher and Begleiter, 1983;Pfefferbaum et al, 1984;Ford et al, 1994). For depressives, the majority of studies also report a reduced P300 amplitude (Roth et al, 1981;Pfefferbaum et al, 1984;Diner et al, 1985;Blackwood et al, 1987;Gandaghar et al, 1993).…”

Section: Introductionmentioning

confidence: 69%

See 1 more Smart Citation

A Confirmatory Study on the Mechanisms Behind Reduced P300 Waves in Depression

Röschke

2003

Neuropsychopharmacol

View full text Add to dashboard Cite

A single-trial analysis of event-related potentials (P300) of 21 depressives was performed in comparison with matched controls. The purpose was to confirm previous results revealing an overall reduction of the single-trial P300 amplitude in depression despite fewer elicited single-trial P300 waves in schizophrenics. The result of the present study is in line with our previous investigation implicating a general reduced P300 amplitude on single trials of depressive patients. Therefore, it appears possible to differentiate depressives and schizophrenics by measuring event-related potentials and applying a single-trial analysis of them.

show abstract

Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 69%

A Confirmatory Study on the Mechanisms Behind Reduced P300 Waves in Depression

Röschke

2003

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…Considering that P300 reflects the cognitive functions associated with attention, anticipation, and the importance of the stimuli, this finding can be evaluated as the electrophysiological interpretation of cognitive dysfunction in patients with depression. Various studies investigating the effect of depression on induced potentials have reported that depression causes a reduction in P300 amplitude (21)(22)(23)(24)(25). Similar to these studies, in the present study there was a decrease in P300 amplitude values with increasing HAM-D scores (p=0.04) ( Table 3).…”

Section: Discussionsupporting

confidence: 80%

Demansı olmayan Parkinson hastalarında işitsel olaya bağlı potansiyel (P300) ile kognitif fonksiyonların değerlendirilmesi

Sarıkaya¹,

Yoldaş²,

Yavaşoğlu³

2014

Dusunen Adam

View full text Add to dashboard Cite

Objective: Idiopathic Parkinson's disease is a clinical situation characterized by akinesia, rigidity, and tremor, and results from the degeneration of the dopaminergic nervous system. As the disease progresses over time, depression, cognitive dysfunction and alterations in cognitive functions are added to the movement disorder at varying rates. The P300 component is a useful parameter for cognitive processing studies on PD patients, as it is independent from motor skills. The current study aimed to show the effects of the PD on the cognitive functions by evaluating the cognitive functions of IPD patients without dementia with the help of an event related potential component, P300 test. Methods: Thirty-eight patients (25 males and 13 females), ranging in age between 40 and 80 years (mean: 58.8 years), were included to the study and the control group consisted of 39 volunteers (25 males and 14 females), ranging in age between 44 and 84 years (mean: 63.5 years), who did not have a history of cerebrovascular disease, dementia, or depression. The participants were informed about the content and the practice of the study, and informed consent forms were obtained. Neurological examination, standardized mini mental test, Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn and Yahr Scale, Hamilton Depression Rating Scale (HAM-D), and P300 tests were performed on the patients. Standardized mini mental test (SMMT), HAM-D, and P300 tests were performed in the control group. Results: P300 latencies in Parkinson's patients were significantly prolonged compared to the control group. There was a decrease in P300 amplitude values with increasing HAM-D. Conclusion: P300 latency reflects the rate of stimuli classification by mental process, attention, and cognitive processing. Even if no dementia is present in PD patients, there is a dysfunction in these functions, and it can be demonstrated by the P300 test, which is independent from motor skills.

show abstract

“…Since the first study conducted by Levit, Sutton, and Zubin (1973), a number of studies have found reduced P300 amplitude in depression (Blackwood et al, 1987;Diner, Holcomb, & Dykman, 1985), although others have failed to replicate this finding (Bruder, Towey, Steward, Friedman, Tenke, & Quitkin, 1991;Have, Kolbeinson, & Pétursson, 1991). Some authors suggest that depressed patients exhibit mainly attentional deficits, which influence earlier ERP components (i.e., N100 and N200) (the auditory N100 component presents a central distribution, it is related to selective attention, and the neural substrate is localised over the temporal cortex involving the primary auditory cortex; the N200 component can be thought of as a cortical concomitant of the orienting response with a fronto-central distribution, and whose cortical generators include temporal and frontal cortexes) and that do not interfere with the P300 component (Smith, Banquet, El Massioui, & Widlocher, 1991).…”

Section: Depressionmentioning

confidence: 99%

Event-Related Brain Potentials in Psychopathology: Clinical and cognitive perspectives

Hansenne

2006

PSYCHOL BELG

View full text Add to dashboard Cite

Since the discovery of the P300 component, a large number of studies have been conducted with the aim to find abnormalities of this psychophysiological marker among the main psychiatric disorders. The first studies were very promising, but successive findings were rather controversial resulting in two main positions (the pros and the cons) as regard to the usefulness of P300 in clinical psychopathology. However, P300 studies provide interesting findings concerning information processing in psychopathology. Moreover, other Event-Related Potentials (ERPs), such as the Mismatch Negativity (MMN) and the Error-Related Negativity (ERN) are particularly interesting for the study of cognitive processes in psychopathology. In this review, the author will give an overview of the main findings of P300, MMN and ERN values in psychopathology from a clinical and a cognitive point of view. After a brief description of the rationale of ERPs, the findings in schizophrenia, depression, alcoholism, posttraumatic stress disorder, panic disorder, and obsessive-compulsive disorder will be sequentially reviewed. The diagnostic usefulness of P300 in psychopathology is limited, but could be increased if variables known to influence P300 amplitude or latency are controlled. Doubtless, grouping two or more different ERP components would greatly improve the usefulness of the clinical applications of brain potentials. On the other hand, a growing number of studies have provided evidence of the relevance of ERPs to investigate cognitive processes in psychopathology.

show abstract

P300 in major depressive disorder

Cited by 122 publications

References 24 publications

A Confirmatory Study on the Mechanisms Behind Reduced P300 Waves in Depression

A Confirmatory Study on the Mechanisms Behind Reduced P300 Waves in Depression

Demansı olmayan Parkinson hastalarında işitsel olaya bağlı potansiyel (P300) ile kognitif fonksiyonların değerlendirilmesi

Event-Related Brain Potentials in Psychopathology: Clinical and cognitive perspectives

Contact Info

Product

Resources

About