P300 subcomponent abnormalities in siblings discordant for schizophrenia

Turetsky, B.; Colbath, E.A.; Cannon, T.D.; Gurl, R.E.

doi:10.1016/0006-3223(96)84461-1

Cited by 6 publications

(10 citation statements)

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“…This component displayed a novelty effect among C3H/HeJ mice, but not the other two strains. As such, this component supports the use of inbred strains of mice to model novelty-evoked potentials that have been proposed to have a genetic determinant (Schreiber et al, 1992;Turetsky et al, 1998bTuretsky et al, , 2000Karoumi et al, 2000;Winterer et al, 2001).…”

Section: Discussionsupporting

confidence: 55%

Effects of Strain, Novelty, and NMDA Blockade on Auditory-Evoked Potentials in Mice

Siegel

Connolly

Liang

et al. 2002

Neuropsychopharmacol

106

112

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People with schizophrenia exhibit impaired ability to modify electroencephalographic event-related potential (ERP) responses to novel stimuli. These deficits serve as a window into the abnormalities of neuronal organization and function and are thought to reflect a component of genetic vulnerability for schizophrenia. We describe differences among inbred mouse strains for ERPs following a novelty detection paradigm, as a model for genetic contributions to disease vulnerability. Auditory-evoked potentials were recorded during an auditory oddball task in nonanesthetized C57BL/6J, C3H/HeJ, and DBA/2J mice prior to and following ketamine (10 mg/kg). Stimuli consisted of 80 sets of 24 standard tones followed by one novel tone. Principal component analysis yielded four temporal components that contribute to the auditory ERP responses to standard and novel stimuli. Two principal components that varied between standard and novel stimuli also differed among inbred mouse strains. Post hoc analyses indicate that strain effects on novelty detection are due to a significant difference between the response to novel and standard tones in C3H/HeJ mice that is absent in the other two strains. Inbred strains of mice vary in their ability to perform neuronal detection of change in the auditory environment. The ability to model novelty detection deficits in mice will aid in identifying genetic contributions to abnormal neuronal organization in people with schizophrenia.

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Section: Discussionsupporting

confidence: 55%

Effects of Strain, Novelty, and NMDA Blockade on Auditory-Evoked Potentials in Mice

Siegel

Connolly

Liang

et al. 2002

Neuropsychopharmacol

106

112

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“…Bauer & Hesselbrock, 1999). P300 abnormalities have also been reported in first-degree relatives of schizophrenia patients (Turetsky & Cannon, 2000;Sponheim et al, 2006;Davenport et al, 2006). In addition, several research findings indicate that P300 amplitude may be associated with risk for substance use disorders.…”

Section: Introductionmentioning

confidence: 90%

Attentional deficits in cocaine-dependent patients: Converging behavioral and electrophysiological evidence

Gooding

Burroughs

Boutros

2008

Psychiatry Research

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Although there are several reports of patients with cocaine dependence displaying cognitive deficits, the nature of their information processing deficits is not well characterized. In the present study, the attentional performance of cocaine-dependent patients (n = 14) was examined and compared with that of healthy control individuals (n = 15). Attention was assessed using an auditory oddball eventrelated task as well as the Continuous Performance Test (CPT; Identical Pairs version). The cocainedependent group displayed P300 amplitude reduction compared to controls. The group difference in P300 response latency did not reach significance. On the CPT, the cocaine-dependent patients displayed significantly poorer discriminability and greater errors of commission than the controls. There was a positive correlation between performance on the oddball event-related task and performance on the CPT. This investigation provides converging behavioral and electrophysiological evidence of attentional deficits in cocaine-dependent patients.

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“…(2) Only studies in which subjects were required to actively discriminate a target from a standard stimulus were used, thereby excluding data obtained from passive ERP procedures (Levit, Sutton, & Zubin, 1973; Roth & Cannon, 1972; Roth, Goodale, & Pfefferbaum, 1991). (3) Only studies that presented data from the initial ERP assessment were included, with subsequent data on the same patients values excluded (Bender et al, 1999; Blackwood et al, 1987; Coburn et al, 1998; Eikmeier et al, 1992; Ford et al, 1994; Hegerl et al, 1988; Knott et al, 1999; Pallanti, Quercioli, & Pazzagli, 1999b; Turetsky et al, 1998b). (4) Any study that employed atypical ERP electrophysiological recording methods was excluded (Contreras et al, 1990).…”

Section: Methodsmentioning

confidence: 99%

“…P300 latency also increases with age at a greater rate for patients with schizophrenia compared to controls (Mathalon, Ford, Rosenbloom, & Pfefferbaum, 2000; O'Donnell et al, 1995). Most studies have not found significant P300 differences between female and male patients (Blackwood, St. Clair, Muir, & Duffy, 1991; Frodl, Meisenzahl, Gallinat, Hegerl, & Moller, 1998; Hegerl, Gaebel, Gutzman, & Ulrich, 1988; Kutcher, Blackwood, St. Clair, Gaskell, & Muir, 1987; Muir, St. Clair, & Blackwood, 1991; St. Clair, Blackwood, & Muir, 1989) except one (Turetsky et al, 1998a), even though gender differences are evident in the presentation and course of schizophrenia (Castle, Abel, Takei, & Murray, 1995; Goldstein, Santangelo, Simpson, & Tsuang, 1990; Goldstein & Tsuang, 1990). Thus, P300 measures are affected by schizophrenia, but exactly how and why this occurs is still unclear (cf.…”

Section: Schizophrenia and P300mentioning

confidence: 96%

“…The oddball paradigm has been most often used to assess patients with schizophrenia, and auditory stimuli demonstrate the strongest P300 effects (Ford, 1999; Pfefferbaum, Ford, White, & Roth, 1989). Several studies have reported that P300 is related to clinical symptom severity, with negative (Eikmeier, Lodemann, Zerbin, & Gastpar, 1992; Galderisi, Maj, Mucci, Monteleone, & Kemali, 1988; Juckel, Muller‐Schubert, Gaebel, & Hegerl, 1996; Maeda, Morita, Kawamura, & Nakazawa, 1996; Merrin & Floyd, 1994; Pallanti, Quercioli, & Pazzagli, 1999a; Pfefferbaum et al, 1989; Strandburg et al, 1994; Strik, Dierks, & Maurer, 1993), positive (Bougerol, Benraiss, & Scotto, 1996; Egan et al, 1994; Kawasaki et al, 1997; McCarley et al, 1989; O'Donnell et al, 1993), and both (Ford, 1999; Frodl‐Bauch, Gallinat, Meisenzahl, Möller, & Hegerl, 1999; Mathalon, Ford, & Pfefferbaum, 2000; Turetsky, Colbath, & Gur, 1998a, 1998b) symptom categories contributing to these findings. In addition, schizophrenia subtypes affect P300, such that component amplitude from patients exhibiting paranoid symptoms is larger than P300 components from disorganized/undifferentiated subtypes using auditory stimuli (Boutros et al, 1997).…”

Section: Schizophrenia and P300mentioning

confidence: 99%

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Meta‐analysis of P300 and schizophrenia: Patients, paradigms, and practical implications

2003

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The goal of the present meta-analysis was to identify factors that contribute to P300 event-related brain potential (ERP) differences in patients with schizophrenia compared to unaffected controls in an attempt to characterize the clinically relevant dimensions underlying P300 deficits in patients with schizophrenia. P300 effect size (d) was smaller in amplitude and longer in latency in schizophrenic patients compared to normal controls, with the strongest effects obtained from the auditory oddball. Paranoid subtype demonstrated larger P300 amplitude effect sizes than other disease subtypes, and P300 latency effect size decreased with disease duration. Psychopathology severity and antipsychotic medications were unrelated to P300 amplitude effect size. Gender proportion, educational level, and stimulus and task variables also affected P300 amplitude and latency effect sizes. The findings are used to formulate a theoretical account of the empirical data and provide suggestions for maximizing the utility of the P300 component in the assessment of schizophrenia.

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P300 subcomponent abnormalities in siblings discordant for schizophrenia

Cited by 6 publications

References 0 publications

Effects of Strain, Novelty, and NMDA Blockade on Auditory-Evoked Potentials in Mice

Effects of Strain, Novelty, and NMDA Blockade on Auditory-Evoked Potentials in Mice

Attentional deficits in cocaine-dependent patients: Converging behavioral and electrophysiological evidence

Meta‐analysis of P300 and schizophrenia: Patients, paradigms, and practical implications

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