P302 Alcohol consumption & breastfeeding: a review of the evidence

Abstract

Background For patients with differentiated thyroid carcinoma (DTC), the effect of radioactive iodine (RAI) therapy on gonadal and reproductive function is an important consideration. Objective and methods 127 children were operated on thyroid in case of DTC during 1975DTC during -2015. 87 pts were treated by RAI (1-13 times). Average age is 15 years (4-18). Histological types of DTC were papillary (69%), follicular (27%), other (4%). Average follow up period is 3 year (2-40). We analyzed effect of therapeutic RAI on sex steroid level; on ovarian function, menses, ovulation in women; sperm in men; future fertility; pregnancy outcomes. Results Early side effects (during 1 st week after RAI) includednausea and vomiting(29%), sialoadenitis (22%), temporal bone marrow dysfunction (6%). Late side effects included permanent salivary glands' dysfunction (2%), permanent bone marrow dysfunction (4%), lung fibrosis (5%), second tumorsleucosis, breast cancer (4%), fertility disorder (7%). Fertility was analyzed in 78 pts. Sterility (2%), amenorrhea (4%), changes in menstrual period (5%), miscarriage (4%). Conclusion RAI should be prescribed only for indications. Sexual cell should be cryopreserve before RAI.

Untitled

“…It is advisable to have low risk consumption of alcohol. Alcohol level peaks in about 30-60mins after ingestion and the infant will receive about 3% of maternal dose of alcohol when fed at peak concentration [68]. Ideally, breast feeding should be started within one hour of birth.…”