P44.05: Data analysis of 993 subjects of fetal malformations from 1999 to 2006

Li, S. L.; Chen, X. L.; Ouyang, Shi; Yao, Yuan; Chen, C. Y.; Yang, Xia; Xiao, Zong-Hui; Liao, Yu-Cai

doi:10.1002/uog.6184

Cited by 2 publications

(5 citation statements)

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“…The four participating hospitals were qualified as regional prenatal diagnosis centers that provided genetic screening and diagnostic testing for fetal defects with high level ultrasound technology [21,22]. …”

Section: Methodsmentioning

confidence: 99%

Association between maternal exposure to housing renovation and offspring with congenital heart disease: a multi-hospital case–control study

Liu

et al. 2013

Environ Health

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BackgroundCongenital heart disease (CHD) is one of the most prevalent birth defects. Housing renovations are a newly recognized source of indoor environmental pollution that is detrimental to health. A growing body of research suggests that maternal occupational exposure to renovation materials may be associated with an increased risk of giving birth to fetuses with CHD. However, the effect of indoor housing renovation exposure on CHD occurrence has not been reported.MethodsA multi-hospital case–control study was designed to investigate the association between maternal periconceptional housing renovation exposure and the risk of CHD for offspring. In total, 346 cases and 408 controls were enrolled in this study from four hospitals in China. Exposure information was based on a questionnaire given to women during pregnancy. The association between housing renovation exposure and CHD occurrence was assessed by estimating odds ratios (OR) with logistic regression models adjusted for potential confounders.ResultsThe risk for CHD in offspring was significantly associated with maternal exposure to housing renovations (AOR: 1.89, 95% CI: 1.29-2.77). There were similar risks for cardiac defects with or without extra-cardiac malformation (AOR of 2.65 and 1.76, respectively). Maternal housing renovation exposure may increase the fetus’ risk of suffering from conotruncal defect or anomalous venous return. There were significant risks for cardiac defects if the pregnant woman moved into a new house within one month after decoration at either 3 months before pregnancy (AOR: 2.38, 95% CI: 1.03 to 5.48) or during first trimester (AOR: 4.00, 95% CI: 1.62 to 9.86).ConclusionsMaternal exposure to housing renovations may have an increased risk of giving birth to fetuses with some selected types of CHD. This relationship was stronger for women who moved into a newly decorated house. However, considering the limited number of subjects and the problem of multiple exposures, more research is needed to clarify the effects seen here.

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Section: Methodsmentioning

confidence: 99%

Association between maternal exposure to housing renovation and offspring with congenital heart disease: a multi-hospital case–control study

Liu

et al. 2013

Environ Health

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“…Besides low-versus high-risk patient selection, the severity and location of a malformation is also critical. Some problems are commonly detected in ultrasonographic images, including severe fetal malformations or malformations of the central nervous system or the genitourinary system [8,9,14,21,22].…”

Section: Introductionmentioning

confidence: 99%

“…Other problems involving the facial area or the heart or the limbs will frequently go unnoticed [16,17,21,22,38,52]. For a number of years, a three-step concept has been recommended to minimize the risk of false diagnoses and to increase detection rates [4].…”

Section: Introductionmentioning

confidence: 99%

“…Neben der Wahl des Patientenkollektivs (low-oder high-risk) spielen dabei auch der Schweregrad der Fehlbildung und die Lokalisation der Malformation eine Rolle. Schwerwiegende fetale Fehlbildungen werden im Ultraschall häufig detektiert, ebenso wie Fehlbildungen des Zentralnervensystems und des Urogenitalsystems [8,9,14,21,22].…”

Section: Introductionunclassified

“…Störungen im Bereich des Gesichts, des Herzen und der peripheren Extremitäten werden dagegen oft nicht entdeckt [16,17,21,22,38,52]. Um die Gefahr von Fehldiagnosen zu minimieren und die Detektionsraten zu erhöhen, wird seit mehreren Jahren ein Dreistufenkonzept empfohlen [4].…”

Section: Introductionunclassified

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