2003
DOI: 10.1016/s0195-668x(03)93948-0
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P510 Inflammation and thrombosis interaction in acute coronary syndrome

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Cited by 2 publications
(3 citation statements)
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“…Several mechanisms have been postulated to account for the association between IL-1 and CRP levels [7][8][9][10]. Besides its indirect role in augmentation of production of other interleukins, such as IL-6, IL-1 directly induces CRP expression at the transcriptional level through two overlapping response elements; binding sites for CCAAT-box/enhancerbinding protein-B (C/ EBP-B) and p50-nuclear factor-κB (p50-NFκB) [9,10].…”
Section: Discussionmentioning
confidence: 99%
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“…Several mechanisms have been postulated to account for the association between IL-1 and CRP levels [7][8][9][10]. Besides its indirect role in augmentation of production of other interleukins, such as IL-6, IL-1 directly induces CRP expression at the transcriptional level through two overlapping response elements; binding sites for CCAAT-box/enhancerbinding protein-B (C/ EBP-B) and p50-nuclear factor-κB (p50-NFκB) [9,10].…”
Section: Discussionmentioning
confidence: 99%
“…Associations of IL1B gene single nucleotide polymor-phisms (SNP) with IL1beta levels [4] and cardiovascular diseases [5,6] have been documented. IL1B levels regulate plasma CRP directly through CRP gene regulation and indirectly through the production of inflammatory mediators such as IL-6 [7][8][9][10][11][12][13]. Findings from previous association studies of IL1B SNPs and CRP levels have been inconsistent [6,[12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%
“…All these detrimental events result in vessel wall thickness and vascular remodeling which induce a susceptibility to CHD. However, mounting evidence supports that chronic inflammation plays a central role in the pathogenesis of CHD, which is recognized to occur from the earliest stages of atheroma formation through to plaque rupture and thrombosis [37] , [38] . Cytokines secreted by inflammatory cells (T cells, mast cells and monocytes) could contribute to the initiation, development and rupture of atherosclerotic plaque [39] [41] .…”
Section: Discussionmentioning
confidence: 99%