p53 and p21 genetic polymorphisms and susceptibility to endometrial cancer1

Association Between p53 codon 72 Polymorphism and Cervical Cancer Risk Among Asians: a Huge Review and Meta-analysis

“…Recently, a number of molecular epidemiological studies have been conducted to examine the association between p53 codon 72 polymorphism (Arg72Pro, rs1042522 G>C) and cervical cancer risk. Roh et al have demonstrated that there is a significant association between p53 gene polymorphisms and cervical cancer risk in Korean women (Roh et al, 2004). Other genetic studies also confirmed that the Pro/Pro genotype of p53 codon 72 polymorphism may increase the risk of cervical cancer in Japanese populations and p53 gene polymorphisms appear to be related to a higher grade of cervical cancer (Ashton et al, 2009;Nunobiki et al, 2009).…”

Polymorphisms in the p53 pathway

“…It seems that for a few tumor types, a combination of the p53 and p21/Waf1 polymorphisms correlates with an increased risk for cancer development. For example, the combination of the Ser genotype of p21/Waf1 codon 31 and the Pro genotype of p53 codon 72 was found associated with increased susceptibility for the development of endometrial cancer in a Korean population (Roh et al, 2004). Likewise, in a Chinese population, patients with the combination of the p21/Waf1 codon 31 Ser/Ser genotype, cytidine at the second intron, and the cytidine in the 3 0 UTR of p21/Waf1 exon 3 plus p53 codon 72 Pro allele were found to have increased risk for development of gastric cancer (Xi et al, 2004), but not lung cancer (Shih et al, 2000).…”

“…Discrepancies among these studies may be explained by inadequate sample sizes or inclusion of different ethnic groups in single studies (Facher et al, 1995;Wu et al, 2004). Additionally, although most studies have tested whether the codon 31 Arg allele is a risk factor for cancer development, three studies have identified the Ser allele as a risk factor for development of cervical cancer (Roh et al, 2001) and endometrial cancer (Roh et al, 2004) in a Korean population and esophageal cancer in a Taiwanese population .…”

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

“…A base substitution at codon 72 of exon 4 of gene p53 that results in either arginine (Arg; CGC) or proline (Pro; CCC) has been identified as polymorphic in human populations (Matlashewski et al, 1987;Dybikowska et al, 2000;Comar et al, 2004;Klug et al, 2009). The association of the p53 codon 72 polymorphism with an increased susceptibility for development of cancer has been examined for many sites (e.g., lung cancer (Piao et al, 2011), gastric cancer (Perez-Perez et al, 2005), and endometrial cancer (Roh et al, 2004)). The HPV E6 oncogene protein binds to TP53 and promotes dysfunction of its activity.…”