p53 and p73 Expression in Esophageal Carcinoma Correlate with Clinicopathology of Tumors

Yan, Bing; Wang, Xuefeng; Yang, Zhenzhong; Sun, Zheng-Ping; Zhang, Rongbo; You-ying, HU; Lu, Youguo; Du, Jiu-Wei

doi:10.5754/hge11964

Cited by 6 publications

(5 citation statements)

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“…Similarly, Liu et al [8] also reported that TP73 was overexpressed in cervical cancer tissues compared with normal cervical tissues. In addition, high expression of TP73 was suggested in several kinds of human tumors such as breast cancer [15,16], esophageal cancer [17], thymic carcinoma [18], extrahepatic bile duct carcinoma [19], cholangiocellular carcinoma [20], hepatocellular carcinoma [21,22], gastric cancer [23,24], colorectal cancer [25–27], ovarian cancer [28], laryngeal cancer [29], parotid gland carcinoma [30], cutaneous melanoma [31] and retinoblastoma [32]. However, low TP73 expression was observed in bladder cancer and head and neck squamous cell carcinoma, compared to corresponding normal tissues [33,34].…”

Section: Discussionmentioning

confidence: 99%

TP73 is a credible biomarker for predicting clinical progression and prognosis in cervical cancer patients

Guo²

2019

Bioscience Reports

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Tumor protein p73 (TP73) has been reported to be dysregulated in various types of human cancer and associated with clinical progression and outcome. Owing to the lack of reports on the correlation between TP73 protein expression and clinicopathologic features of cervical cancer, the aim of our research was to explore the clinical and prognostic significance of TP73 protein expression in cervical cancer patients. In our study, TP73 protein expression was detected by immunochemistry in 118 paraffin-embedded cervical cancer tissue specimens and 40 paraffin-embedded normal cervical epithelium tissue specimens. In the results, we found cervical cancer tissues exhibited high TP73 expression in comparison with normal cervical epithelium tissues, which was consistent with the expression status of TP73 in The Cancer Genome Atlas (TCGA) database. Furthermore, we analyzed the relationships between TP73 expression and clinicopathologic features through using the chi-square test or Fisher’s exact test, and found high expression of TP73 was markedly associated with early clinical stage, less lymph node metastasis, absent distant metastasis, squamous cell carcinoma and favorable histological grade. The Kaplan–Meier method and log-rank test were performed based on the expression level of TP73 in a cervical cancer cohort from the TCGA database, and showed that TP73 expression was positively correlated with overall survival time in cervical cancer patients. Moreover, univariate and multivariate Cox proportional hazards regression model indicated that high TP73 expression was identified as an independent factor for predicting favorable overall survival in cervical cancer patients. In conclusion, TP73 expression is increased in cervical cancer tissues and cells, and acts as a credible biomarker for predicting favorable overall survival in cervical cancer patients.

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Section: Discussionmentioning

confidence: 99%

TP73 is a credible biomarker for predicting clinical progression and prognosis in cervical cancer patients

Guo²

2019

Bioscience Reports

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“…Bahnassy et al (2005) and Huang et al (2014) found that high p53 expression was associated with a poor survival rate in ESCC patients [ 42 , 43 ]; and Han et al (2007) showed that p53 expression was positively correlated with tumor stage and lymph node metastasis [ 44 ]. Ye et al (2012) reported that p53 expression was not associated with the gender or age of the patient, but was associated with tumor differentiation degree and lymph node metastasis [ 45 ]. A retrospective cohort study of 136 ESCC patients, conducted to investigate the prognostic role of p53 in patients with ESCC suggested that overexpression of this protein was associated with poor prognosis in these patients, and it’s a significantly independent predictor of poorer overall survival ( p = 0.04) [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

HPV infection and p53 and p16 expression in esophageal cancer: are they prognostic factors?

Costa

Fregnani

Pastrez

et al. 2017

Infect Agents Cancer

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BackgroundEsophageal squamous cell carcinoma (ESCC) is a highly lethal malignant tumor. Currently, Human papillomavirus (HPV) is suggested as a potential risk factor for esophageal cancer (EC) in addition to the classic risk factors, alcohol and tobacco, but this hypothesis still remains contradictory. We sought to investigate wether HPV and well-known biomarkers (p16 and p53) and patient-related factors that may have impact on survival of ESCC.MethodsWe conducted a prospective cohort study. By using multiplex PCR, we determined the prevalence of high risk HPV in ESCC, and evaluated the immunohistochemical expression of p16 and p53, molecular markers related to esophageal carcinogenesis in order to verify the potential influence of these variables in patients’s survival. Survival rates were estimated using Kaplan-Meier methods. A multivariate confirmatory model was performed using Cox proportional hazards regression.ResultsTwelve (13.8%) of 87 patients were HPV-DNA positive. Positive reactions of p16 and p53 were 10.7% and 68.6%, respectively. Kaplan-Meier analysis indicated that men (p = 0.025) had poor specific-cancer survival and a shorter progression-free survival (p = 0.050) as compared to women; III or IV clinical stage (p < 0.019) had poor specific-cancer survival and a shorter progression-free survival (p < 0.001) compared to I and II clinical stage; not submitted to surgery (<0.001) and not submitted to chemoradiotherapy (p = 0.039) had a poor specific-cancer survival, as well. The multivariate analysis showed that HPV, p16 and p53 status are not predictive parameters of progression-free and specific-cancer survival.ConclusionHPV infection and p53 and p16 expression are not prognostic factors in ESCC.

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“…27 Other studies have also shown overexpression of p53 protein in normal tissue adjacent to tumor or preneoplastic lesions in various cancers. 28,29 The association of p53 expression by IHC with the LOH for the p53 gene (D17S786) was, however, only modest. In LOH+ cases, overexpression of the p53 protein was seen in most of the cases.…”

Section: Association Of Ihc With Lohmentioning

confidence: 98%

Sequential Occurrence of Preneoplastic Lesions and Accumulation of Loss of Heterozygosity in Patients With Gallbladder Stones Suggest Causal Association With Gallbladder Cancer

Jain

Mohapatra

Das³

et al. 2014

Annals of Surgery

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p53 and p73 Expression in Esophageal Carcinoma Correlate with Clinicopathology of Tumors

Abstract: Increased expression of p53 and p73 in esophageal carcinoma may serve as an indicator of tumor severity. Detection of these proteins in future studies may help understand the mechanisms of development, invasion and metastasis in esophageal cancer.

Cited by 6 publications

References 0 publications

TP73 is a credible biomarker for predicting clinical progression and prognosis in cervical cancer patients

TP73 is a credible biomarker for predicting clinical progression and prognosis in cervical cancer patients

HPV infection and p53 and p16 expression in esophageal cancer: are they prognostic factors?

Sequential Occurrence of Preneoplastic Lesions and Accumulation of Loss of Heterozygosity in Patients With Gallbladder Stones Suggest Causal Association With Gallbladder Cancer

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