p53 Protein in Benign and Malignant Sweat Gland Tumors

Wienecke, R.; Eckert, F.; Kaudewitz, Peter; Viragh, Pierre A. de; Heidl, G.; Volkenandt, Matthias

doi:10.1097/00000372-199404000-00003

Cited by 17 publications

(5 citation statements)

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“…In contrast, little is known about molecular alterations underlying the development of sweat gland tumours. Accumulation of p53 protein has been observed in 23-80% of sweat gland tumours (Biernat and Wozniak, 1996;Wienecke et al, 1994). We have shown that p53 protein accumulation is frequent in sweat gland carcinomas (10 of 14; 71%) but rare in sweat gland adenomas (3 of 60; 5%) (Biernat and Wozniak, 1996).…”

Section: Wiley-liss Incmentioning

confidence: 72%

p53 mutations in sweat gland carcinomas

et al. 1998

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Sweat gland carcinomas are rare skin tumours and little is known about their etiology and molecular basis. In this study, we analyzed p53 mutations in 16 sweat gland carcinomas with different histologic types, including 2 spiradenocarcinomas, 1 composed adnexal carcinoma, 5 porocarcinomas, 2 eccrine hidradenocarcinomas, 2 syringocystadenocarcinomas, 1 sclerosing sweat gland carcinoma, 1 adenoid cystic carcinoma, 1 cylindrocarcinoma and 1 apocrine adenocarcinoma. Single‐stranded conformation polymorphism (SSCP) analyses followed by direct DNA sequencing revealed that 5 carcinomas (31%) contained a p53mutation, 4 of which were G:C|iOA:T transition mutations and 1 of which was a deletion. Three G:C|iOA:T mutations were located at dipyrimidine sequences on the antisense strand (2 spiradenocarcinomas, 1 eccrine hidradenocarcinoma), suggesting that UV light may play a role in the development of sweat gland carcinomas. In 2 spiradenocarcinomas, p53 mutations were present in the carcinoma but not in the adenoma portions, suggesting that p53 mutations may be associated with malignant progression in these rare adnexal tumours. Int. J. Cancer 76:317–320, 1998.© 1998 Wiley‐Liss, Inc.

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Section: Wiley-liss Incmentioning

confidence: 72%

p53 mutations in sweat gland carcinomas

et al. 1998

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“…They concluded that p53 mutations might play a role in a subset of sweat gland tumours, including extramammary Paget's disease. 83 p53 expression does not appear to have prognostic relevance in Paget's disease. 84 c-erbB-2 oncogene expression has been discussed above.…”

Section: Cytogeneticsmentioning

confidence: 86%

Mammary and extramammary Paget's disease

Lloyd

Flanagan²

2000

Journal of Clinical Pathology

382

387

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“…p53 is a tumor suppressor gene-nucleoprotein that functions in controlling the cell cycle by inhibiting DNA replication. Mutant p53 has been associated with a wide variety of malignancies of different human organs (14,15) including the skin (9,(16)(17)(18). Recently, it has also been reported to accumulate in premalignant lesions of the skin, suggesting involvement ofthe mutant gene in early stages of carcinogenesis (16,19).…”

Section: Discussionmentioning

confidence: 99%

“…p53 over-expression has been detected in numerous malignant tumors, including those of fibrocytic and fibrohistiocytic origin (4)(5)(6). Only a few cases of benign processes are reported to overexpress the protein (4,5,(7)(8)(9).…”

mentioning

confidence: 99%

Comparison of p53 expression in dermatofibrosarcoma protuberans and dermatofibroma: Lack of correlation with proliferation rate

et al. 1995

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p53 protein plays an important role in control of cell proliferation by suppressing proliferation of cells with DNA damage. Mutations of the p53 gene increase the stability of the encoded nonfunctional protein which accumulates in the nuclei, allowing it to be detectable by immunohistochemistry. Mutant p53 protein has been observed in preneoplastic and neoplastic conditions supporting its role in the development of some human cancers. In this immunohistochemical study, we examined p53 expression in 12 Dermatofibrosarcoma Protuberans (DFSP) and 10 Dermatofibromas (DF). Results were compared with the cellular proliferation rate by using the monoclonal antibody Mib-1 which detects Ki-67 antigen expression. Nuclear accumulation of the p53 protein was observed in 11 DFSP. All DF were negative for p53. No statistical correlation could be established between p53 and Mib-1 staining in our cases. We conclude that mutations of the p53 gene may be involved in the molecular pathogenesis of DFSP but not of DF. Mib-1 index can not be successfully used to distinguish DFSP from DF.

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p53 Protein in Benign and Malignant Sweat Gland Tumors

Cited by 17 publications

References 0 publications

p53 mutations in sweat gland carcinomas

p53 mutations in sweat gland carcinomas

Mammary and extramammary Paget's disease

Comparison of p53 expression in dermatofibrosarcoma protuberans and dermatofibroma: Lack of correlation with proliferation rate

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