P53- The Molecular Guardian Crashes in Gastric Adenocarcinomas - A Study in an Ethnic Kashmiri Population

Abdullah, Safiya; A, Syed Sameer; Dil-Afroze,; Syeed, Nidda; Bc, Das; Siddiqi, Mushtaq A.

doi:10.4172/2157-2518.1000106

Cited by 9 publications

(14 citation statements)

References 60 publications

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“…According to the results, there was a significant association between GC and R282W mutation in the studied population in the Southwest of Iran. Abdullah and colleagues showed that 20% of gastric patients in Kashmir Valley harbor R282W mutation of P53 gene (30), which is in accordance with the present study. Fischer and colleagues found a strong association between R282W P53 mutation and GC in Toronto, where P53 mutation was identified in 40% of cases (31).…”

Section: Discussionsupporting

confidence: 92%

Detection of R282w P53 Gene Mutation on Exon 8 in Gastric Cancer Patients in Southwest Iran

et al. 2020

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Background: Gastric adenocarcinoma is the most common type of gastric cancer all around the world. The epithelial cells of stomach tissue are influenced by environmental factors and genetic disorders. P53 is the most remarkable gene that controls the growth of cells. Mutation in some nucleotides of the P53 gene increases the genetic instability and is assumed as an important prognostic factor in gastric cancer. More than 90% of mutations occur in the exons 5-8 of p53. Objectives: This study was conducted in Kohgiluyeh and Boyer Ahmad (K&B) province (Southwest Iran) to determine the rate of R282W P53 gene mutation of exon 8 in gastric cancer. Methods: This case-control study was conducted on 90 subjects that were divided into two groups (each including 45 patients and 45 controls). The samples were randomly collected from the tissue bank of the pathology laboratory in Yasuj city and then were transferred to the Cellular and Molecular Research Center. DNA extraction was performed by the DNA extraction kit. Molecular analysis on exon 8 was performed by the PCR-RFLP method and using the MspI restricting enzyme. Data were analyzed by descriptive statistics and bivariate correlation tests. Results: No difference was found between the two groups concerning age, gender, and education level. The prevalence of R282W P53 gene mutation on exon 8 in the cancer group was 17.8% (8/45), while no mutation was found in the control group. Conclusions: According to the results, the R282W P53 gene mutation on exon 8 may play an important role in the development of gastric cancer in Yasuj district, Southwest Iran.

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Section: Discussionsupporting

confidence: 92%

Detection of R282w P53 Gene Mutation on Exon 8 in Gastric Cancer Patients in Southwest Iran

et al. 2020

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“…In conclusion, the results of the present investigation clearly indicate that [66] the direct sequencing results, therefore, shall help in understanding the molecular events associated with environmental microbes [67]. In addition, gene expression profiling may provide mechanistic insights that may subsequently be employed to develop biomarkers to detect chemical toxicity as well as strategies to intervene chemical toxicity [68].…”

Section: Pcrmentioning

confidence: 55%

J Microbial Biochem Technol

Srilatha¹

2011

J Microbial Biochem Technol

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Genomic investigations into the diversity of environmental microbes are leading to insights into ecological dynamics, the evolution of new forms of biological systems, and the discovery of new functions that might be exploited for biotechnological and biomedical purposes. It is now clear that an understanding of the community structure, function and evolution of bacteria in their natural environments is required to meet the promise of microbial biotechnology. To meet these new challenges, microbiologists are applying the tools of genomics and related highthroughput technologies to both cultured microbes and environmental samples. This work will lead to new views on ecosystems and biological function together with the biotechnology enabled by this science.

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“…50% of all tumors contain p53 mutants. If p53 is damaged, tumor suppression is severely reduced [42]. Over expression of the nuclear phosphoprotein p53 is one of the most common abnormalities in primary human cancer and appears to be due to point mutation within a highly conserved region of the p53 gene which then encodes for a mutant, more stable protein [43].…”

Section: P53mentioning

confidence: 99%

Epidemiology of Genetic Alterations in Progression of Breast Cancer

P¹

2012

J Carcinogene Mutagene

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Breast cancer is the most frequent cancer in women responsible for almost 20% of all cancer deaths. Certain aberrations in the genes results higher risk in the development of breast cancer. The present review aims to consolidate a comprehensive role of different genes involved in the development of breast cancer. This helps to know the intracellular molecular changes in tumorigenic pathways within the mammary gland.

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P53- The Molecular Guardian Crashes in Gastric Adenocarcinomas - A Study in an Ethnic Kashmiri Population

Cited by 9 publications

References 60 publications

Detection of R282w P53 Gene Mutation on Exon 8 in Gastric Cancer Patients in Southwest Iran

Detection of R282w P53 Gene Mutation on Exon 8 in Gastric Cancer Patients in Southwest Iran

J Microbial Biochem Technol

Epidemiology of Genetic Alterations in Progression of Breast Cancer

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