2018
DOI: 10.1016/j.isci.2018.09.018
|View full text |Cite
|
Sign up to set email alerts
|

p73 Is Required for Ovarian Follicle Development and Regulates a Gene Network Involved in Cell-to-Cell Adhesion

Abstract: SummaryWe report that p73 is expressed in ovarian granulosa cells and that loss of p73 leads to attenuated follicle development, ovulation, and corpus luteum formation, resulting in decreased levels of circulating progesterone and defects in mammary gland branching. Ectopic progesterone in p73-deficient mice completely rescued the mammary branching and partially rescued the ovarian follicle development defects. Performing RNA sequencing (RNA-seq) on transcripts from murine wild-type and p73-deficient antral fo… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

5
27
0

Year Published

2019
2019
2022
2022

Publication Types

Select...
6
1

Relationship

1
6

Authors

Journals

citations
Cited by 17 publications
(32 citation statements)
references
References 66 publications
5
27
0
Order By: Relevance
“…These findings were corroborated by an independent study (Inoue et al, 2014). In remarkable evolutionary convergence, p73 is also required for ovarian folliculogenesis (Santos Guasch et al, 2018). Mechanistically, p73 regulates the cell-cell adhesion network in granulosa cells, which line the primary, secondary, antral and ovulating ovarian follicles (Fig.…”
Section: Roles Of Tap73 In Male and Female Reproductionsupporting
confidence: 59%
See 3 more Smart Citations
“…These findings were corroborated by an independent study (Inoue et al, 2014). In remarkable evolutionary convergence, p73 is also required for ovarian folliculogenesis (Santos Guasch et al, 2018). Mechanistically, p73 regulates the cell-cell adhesion network in granulosa cells, which line the primary, secondary, antral and ovulating ovarian follicles (Fig.…”
Section: Roles Of Tap73 In Male and Female Reproductionsupporting
confidence: 59%
“…In mouse ovaries, p73 is expressed in granulosa cells. Human ovaries express predominantly TAp73α and TAp73β (Santos Guasch et al, 2018). p73KO ovaries exhibit a 35-60% decrease in the ratio of primary versus antral follicles compared to wild-type (but no difference in primordial follicles), and a >90% decrease in the number of corpora lutea.…”
Section: Roles Of Tap73 In Male and Female Reproductionmentioning
confidence: 98%
See 2 more Smart Citations
“…In particular, 27 genes have been identified in which mutations disrupt intercellular adhesion during collective migration. For example, p73, which is important for folliculogenesis of the ovaries, functions as a vital regulator of a gene network involved in cell-to-cell adhesion and migration [81]. The nuclear retinoic acid receptors (retinoic acid receptor alpha, RARα, retinoic acid receptor beta, RARβ, and retinoic acid receptor gamma, RARγ) are ligand-dependent transcription factors regulating the expression of genes related to cell differentiation and proliferation.…”
Section: Remodeling Of Cytoskeletons In Intercellular Interactionsmentioning
confidence: 99%