P842 a Study of Risk Factors Associated With Nonalcoholic Fatty Liver Disease [Nafld] in Indians

Singh, Sukhpreet; Misra, Debasis; Singh, Ayaskanta; Misra, Bijay; Pati, Girish Kumar; Panigrahi, Manas; Kar, Sibabrata; Meher, Chudamani; Agrawal, Omprakash

doi:10.1016/s0168-8278(14)61003-5

Cited by 5 publications

(7 citation statements)

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“…The present study showed a higher proportion of males in the NAFLD group, which was similar to the earlier studies from India. 3,4 NAFLD patients had a mean age of 42.15 years, which matches the age of the cohort in the NAFLD series of Madan et al 12 and Duseja et al 13 The metabolic factors such as fasting blood sugar levels and serum triglyceride levels were significantly higher in the NAFLD group as compared to the control population. This result is expected as NAFLD is considered to be the hepatic manifestation of metabolic syndrome.…”

Section: Discussionsupporting

confidence: 68%

“…Sample size of the study was calculated using results of a previous study from our centre. 3 Taking power of study as 90% and P value = 0.001, we calculated the sample size to be 109 (81 cases and 27 controls) by using Real statistic add-in of excel software (2013 version). As we had a large database of NAFLD subjects (1182 subjects) we utilized the available data for maximum power of the study.…”

Section: Discussionmentioning

confidence: 99%

“…The alarming rise in the prevalence can be attributed to adoption of sedentary lifestyle, dietary transition and the obesity epidemic. 3 NAFLD is a cause for concern, since it is not a benign static disease, but can progress to steatohepatitis, fibrosis, cirrhosis and rarely hepatocellular carcinoma. 4,5 Central obesity rather than overall obesity has a strong pathogenetic link to NAFLD.…”

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confidence: 99%

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Simple Anthropometric Indices are Useful for Predicting Non-alcoholic Fatty Liver Disease [NAFLD] in Asian Indians

Singh

Parida

Narayan

et al. 2017

Journal of Clinical and Experimental Hepatology

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The simple anthropometric parameters, such as BMI, waist circumference, waist-hip ratio and waist-height ratio are useful for predicting NAFLD in Indian adults. The anthropometry cut offs would be very useful in setting target points of life style modification and weight reduction. Besides, our study also clearly demonstrated that a simple assessment of BMI is as efficacious as other anthropometry parameters in predicting NAFLD.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Simple Anthropometric Indices are Useful for Predicting Non-alcoholic Fatty Liver Disease [NAFLD] in Asian Indians

Singh

Parida

Narayan

et al. 2017

Journal of Clinical and Experimental Hepatology

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“…In a case-control study in India, consumption of non-vegetarian diet was associated with NAFLD. 118 In a cross sectional study in Israel, NAFLD patients consumed 27% more all types of meat than controls, and the association remained significant with adjustment for age, gender, BMI and total calories. 41 In contrast to NAFLD, the association with meat consumption was intensively studied in diabetes and CVD.…”

Section: Red and Processed Meatmentioning

confidence: 96%

The Mediterranean dietary pattern as the diet of choice for non‐alcoholic fatty liver disease: Evidence and plausible mechanisms

Zelber‐Sagi

Salomone²,

Mlynarsky

2017

Liver International

210

162

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Non-alcoholic fatty liver disease (NAFLD) has become a major global health burden, leading to increased risk for cirrhosis, hepatocellular carcinoma, type-2 diabetes and cardiovascular disease. Lifestyle intervention aiming at weight reduction is the most established treatment. However, changing the dietary composition even without weight loss can also reduce steatosis and improve metabolic alterations as insulin resistance and lipid profile. The Mediterranean diet (MD) pattern has been proposed as appropriate for this goal, and was recommended as the diet of choice for the treatment of NAFLD by the EASL-EASD-EASO Clinical Practice Guidelines. The MD has an established superiority in long term weight reduction over low fat diet, but it improves metabolic status and steatosis even without it.However, the effect on liver inflammation and fibrosis was tested only in few observational studies with positive results. Furthermore, considering the strong association between NAFLD and diabetes and CVD, the MD has a highly established advantage in prevention of these diseases, demonstrated in randomized clinical trials. The individual components of the MD such as olive oil, fish, nuts, whole grains, fruits, and vegetables, have been shown to beneficially effect or negatively correlate with NAFLD, while consumption of components that characterize a Western dietary pattern as soft drinks, fructose, meat and saturated fatty acids have been shown to have detrimental association with NAFLD. In this review we will cover the epidemiological evidence and the plausible molecular mechanisms by which the MD as a whole and each of its components can be of benefit in NAFLD.

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“…However, there is evidence that it should be 600 kcal less than the usual energy requirement to remain at the same weight until the target weight is achieved . The target weight of a body mass index (BMI) of 22 kg/m 2 can be set for patients during their treatment because it is the cut‐off point for a high risk of developing NAFLD . In patients with NAFLD, a reduction in weight of around 3‐5% by diet therapy, with or without exercise, has been shown to reduce hepatic steatosis .…”

Section: Lifestyle Modification and Nafldmentioning

confidence: 99%

What are the main areas of focus to prevent or treat non‐alcoholic fatty liver disease?

Mansour

Hekmatdoost

Mirmiran

2019

J of Digest Diseases

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Recently, a growing body of information has accumulated to suggest that nutritional status and food compounds impact on the development or progression of nonalcoholic fatty liver disease (NAFLD). The best strategy to prevent and treat NAFLD is to modify diet and lifestyle by maintaining a healthy weight, following a wellbalanced diet with appropriate energy intake and increasing physical activity or strength training. Here we review the literatures and discuss existing and potential therapeutic strategies for the prevention and management of NAFLD, emphasizing the description of nutritional status and its clinical impact on the outcomes of NAFLD.diet, drug, lifestyle, non-alcoholic fatty liver disease, nutrition, weight loss

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P842 a Study of Risk Factors Associated With Nonalcoholic Fatty Liver Disease [Nafld] in Indians

Cited by 5 publications

References 0 publications

Simple Anthropometric Indices are Useful for Predicting Non-alcoholic Fatty Liver Disease [NAFLD] in Asian Indians

Simple Anthropometric Indices are Useful for Predicting Non-alcoholic Fatty Liver Disease [NAFLD] in Asian Indians

The Mediterranean dietary pattern as the diet of choice for non‐alcoholic fatty liver disease: Evidence and plausible mechanisms

What are the main areas of focus to prevent or treat non‐alcoholic fatty liver disease?

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