PAC clone containing the
            <i>HMGI(Y)</i>
            gene spans the breakpoint of a 6p21 translocation in a uterine leiomyoma cell line

Kazmierczak, Bernd; Bol, Silvia; Wanschura, S.; Bartnitzke, Sabine; Bullerdiek, Jörn

doi:10.1002/(sici)1098-2264(199611)17:3<191::aid-gcc8>3.0.co;2-#

Cited by 40 publications

(8 citation statements)

References 9 publications

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“…A single genomic clone including HMGIY was found to span the breakpoint in a uterine leiomyoma with a complex rearrangement involving chromosome region 6p21.3 (Kazmierczak et al, 1996a). Subsequent studies demonstrated rearrangement of the HMGIY locus in hamartoma of the breast (Dal Cin et al, 1997b), a pericentric inversion of chromosome 6 involving band p21 in a uterine leiomyoma (Williams et al, 1997), and a translocation leading to an intergenic fusion with the LAMA4 gene (laminin a4) in a pulmonary chondroid hamartoma (Xiao et al, 1997).…”

Section: Chromosomementioning

confidence: 99%

Genetics of uterine leiomyomata

Ligon

Morton

2000

Genes Chromosom. Cancer

108

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Section: Chromosomementioning

confidence: 99%

Genetics of uterine leiomyomata

Ligon

Morton

2000

Genes Chromosom. Cancer

108

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“…The subsequent probe sets were used: biotin-labeled PAC-59-C23 clone [containing the HMGI (Y) gene that maps to 6p21.3 region] [11], together with the Spectrum- …”

Section: Methodsmentioning

confidence: 99%

Aneurysmal bone cyst of the nose with 17p13 involvement

et al. 2001

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We report on a 6-year-old girl with a polypoid mass, filling up the entire right nasal cavity as shown on a magnetic resonance imaging scan. Histologically, the tumor had the characteristics of an aneurysmal bone cyst, which is extremely rare in this location. Cytogenetic analysis disclosed a single (6:17)(p21;p13) translocation, confirming a specific genetic involvement in the development of aneurysmal bone cysts. Fluorescent in situ hybridization analysis mapped the putative gene between the p53 (17p13.1) and the Mieller-Dieker gene (17p13.3) loci.

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“…Recently, rearrangements of the HMG(Y) characterised by involvement of 6p21 have been demonstrated in benign mesenchymal tumours such as uterine leiomyomas [56,57].…”

Section: Adipose Tissue Tumoursmentioning

confidence: 99%

The role of cytogenetics in the classification of soft tissue tumours

1997

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Soft tissue tumours represent a heterogeneous group of mesenchymal lesions, and their classification is the subject of continuous debate. Chromosome analysis, molecular cytogenetics and molecular assays may become increasingly useful in diagnosis, and this review summarises advances in the cytogenetic characterisation and classification of soft tissue tumours. Among the group of fibrous lesions, superficial fibromatosis exhibits trisomy 8. This genomic change is also observed in desmoid fibromatosis in association with trisomy 20. Trisomy 11 is the most frequently observed chromosomal aberration in congenital fibrosarcoma. Dermatofibrosarcoma protuberans and giant cell fibroblastoma share a translocation t(17;22), which supports the concept of the existence of a common differentiation pathway. Adipose tissue tumours is the group in which integration of genetics and pathology has been most fruitful. Ordinary lipomas cytogenetically show an abnormal karyotype in about half the cases. Genomic changes of the 11q13 region are observed in hibernoma. Lipoblastoma exhibits a specific 8q rearrangement in 8q11-q13. Loss of material from the region 16q13-qter and 13q deletions are observed in spindle cell/pleomorphic lipomas. The well-differentiated liposarcoma/atypical lipoma group is characterised karyotypically by the presence of one extra ring and/or extra giant chromosome marker. Myxoid and round cell liposarcoma share the same characteristic chromosome change: t(12;16)(q13;p11) in most cases. In the group of smooth muscle lesions most data are derived from uterine leiomyomas, which can be subclassified cytogenetically into seven different types. Half of all leiomyomas are chromosomally normal; the other half have one of six possible consistent chromosome changes. Alveolar rhabdomyosarcoma is characterised cytogenetically by two variant translocations t(2;13)(q35;q14) and t(1;13)(p36;q14). Among tenosynovial tumours, the localised type of giant cell tumour of tendon sheath exhibits two different karyotypic changes. One involves 1p11 in a translocation with chromosome 2 or with another chromosome. A second type involves 16q24. Synovial sarcoma is characterised cytogenetically by a translocation occurring between chromosome 18 and presumably two adjacent loci on the X chromosome. In neural tumours, abnormalities of chromosome 22 have been reported in benign schwannomas and perineuriomas. Malignant peripheral nerve sheath tumours exist in two main forms: sporadic and associated with the NF-1 syndrome. Karyotypes are very complex, but chromosomes 17q and 22q are very often involved. Clear cell sarcoma is characterised cytogenetically and molecularly by a translocation t(12;22)(q13;q12). The Ewing's sarcoma/peripheral neuroectodermal tumour category shows a central karyotypic anomaly represented by the translocation t(11;22). The two variants t(21;22) and t(7;22) are found in some cases. Among cartilaginous lesion, the most frequently described anomaly is the t(9;22)(q22;q12) in extraskeletal myxoid chondrosarcoma. Intra-ab...

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PAC clone containing the HMGI(Y) gene spans the breakpoint of a 6p21 translocation in a uterine leiomyoma cell line

Cited by 40 publications

References 9 publications

Genetics of uterine leiomyomata

Genetics of uterine leiomyomata

Aneurysmal bone cyst of the nose with 17p13 involvement

The role of cytogenetics in the classification of soft tissue tumours

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