PAC1 receptors in chick cerebral cortex: characterization by binding of pituitary adenylate cyclase-activating polypeptide, [125I]-PACAP27

Zawilska, Jolanta B.; Niewiadomski, Piotr; Nowak, Jerzy Z.

doi:10.1016/s0304-3940(02)01397-6

Cited by 14 publications

(14 citation statements)

References 23 publications

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“…These data are consistent with the known affinities of VIP receptors: Avian and mammalian VIP receptors exhibit a high affinity for both VIP and PACAP (hence these receptors are sometimes referred to as VPAC receptors), whereas the single PACAP receptor in birds and mammals is highly selective for PACAP (Vaudry et al, 2000;Zawilska et al, 2003).…”

Section: Nih-pa Author Manuscriptsupporting

confidence: 87%

“…Using the same 125 I-VIP employed here (human/porcine/rat; Perkin-Elmer Life Sciences, Boston MA), it has been shown that specific binding sites in turkey telencephalon exhibit a high affinity for both VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) (Zawilska et al, 2004). These data are consistent with the known affinities of VIP receptors: Avian and mammalian VIP receptors exhibit a high affinity for both VIP and PACAP (hence these receptors are sometimes referred to as VPAC receptors), whereas the single PACAP receptor in birds and mammals is highly selective for PACAP (Vaudry et al, 2000;Zawilska et al, 2003).…”

Section: Avian Neuropeptide Receptors and Selection Of Iodinated Ligandssupporting

confidence: 87%

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Neuropeptide binding reflects convergent and divergent evolution in species-typical group sizes

Goodson

Evans

Wang

2006

Hormones and Behavior

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Neuroendocrine factors that produce species differences in aggregation behavior ("sociality") are largely unknown, although relevant studies should yield important insights into mechanisms of affiliation and social evolution. We here focused on five species in the avian family Estrildidae that differ selectively in their species-typical group sizes (all species are monogamous and occupy similar habitats). These include two highly gregarious species that independently evolved coloniality; two territorial species that independently evolved territoriality; and an intermediate, modestly gregarious species that is a sympatric congener of one of the territorial species. Using males and females of each species, we examined binding sites for 125 I-vasoactive intestinal polypeptide (VIP), 125 I-sauvagine (SG; a ligand for corticotropin releasing factor, CRF, receptors) and a linear 125 I-V 1a vasopressin antagonist (to localize receptors for vasotocin, VT). VIP, CRF and VT are neuropeptides that influence stress, anxiety and/or various social behaviors. For numerous areas (particularly within the septal complex), binding densities in the territorial species differed significantly from binding in the more gregarious species, and in most of these cases, binding densities for the moderately greagarious species were either comparable to the two colonial species, or were intermediate to the territorial and colonial species. Such patterns were observed for 125 I-VIP binding in the medial bed nucleus of the stria terminalis, medial septum, septohippocampal septum, and subpallial zones of the lateral septum; for 125 I-SG binding in the infundibular hypothalamus, and lateral and medial divisions of the ventromedial hypothalamus; and for the linear 125 I-V 1a antagonist in the medial septum, and the pallial and subpallial zones of the caudal lateral septum. With the exception of 125 I-SG binding in the infundibular hypothalamus, binding densitites are positively related to sociality. Keywords lateral septum; hypothalamus; vasotocin; vasopressin; corticotropin releasing factor; vasoactive intestinal polypeptide; evolution; sociality; songbird Components of social organization can change rapidly during evolution, as suggested by the fact that many vertebrate groups exhibit substantial diversity in behavioral dimensions such as grouping, mating systems, patterns of parental care, philopatry and kin affiliation. Thus, a given form of behavior or social structure may have evolved independently many times in various vertebrate lineages. Somewhat inconveniently, the evolution of a given species-typical social structure could hypothetically be produced by more than one kind of evolutionary modification to the brain, reducing our ability to generalize across species. Species-typical group size ("sociality") provides a good example: Natural selection on aggregation behavior could conceivably act on neural mechanisms that relate to anxiety, stress, aggression, reward, bonding, and/or simple arousal to social stimuli 1 . Therefore, in...

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Section: Nih-pa Author Manuscriptsupporting

confidence: 87%

Section: Avian Neuropeptide Receptors and Selection Of Iodinated Ligandssupporting

confidence: 87%

Neuropeptide binding reflects convergent and divergent evolution in species-typical group sizes

Goodson

Evans

Wang

2006

Hormones and Behavior

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“…8) (Cauvin et al, 1991;Masuo et al, 1991;Suda et al, 1991;Masuo et al, 1992;Hou et al, 1994;Zawilska et al, 2003;Jolivel et al, 2009). Significant densities of type I binding sites are also present in the cerebellum (Basille et al, 1993 and pons (Cauvin et al, 1991; ͔VIP (1-7)/GHRH (8-27) VPAC2-R Ro 25-1392 (Xia et al, 1997) Antagonists PAC1-R des(24-42)Maxadilan (M65) (Moro et al, 1999) PACAP(6-38) Weak VPAC2-R agonist (Robberecht et al, 1992b) Hydrazides No information regarding VPAC1/VPAC2-R (Beebe et al, 2008) ͓Sar…”

Section: E Distribution Of Pituitary Adenylate Cyclaseactivating Polmentioning

confidence: 99%

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

et al. 2009

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“…Avian and mammalian VIP receptors exhibit a high affinity for both VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) whereas the single avian and mammalian PACAP receptor is highly selective for PACAP [Vaudry et al, 2000;Zawilska et al, 2003]. The ligand that we use, 125 I-VIP (human/porcine/rat; Perkin-Elmer Life Sciences, Boston, Mass., USA) has been shown to label binding sites in the turkey telencephalon that exhibit a high affinity for both VIP and PACAP [Zawilska et al, 2004].…”

Section: Selection Of Iodinated Ligandsmentioning

confidence: 99%

Seasonal Variation in Group Size Is Related to Seasonal Variation in Neuropeptide Receptor Density

Wilson

Goodson

Kingsbury³

2016

Brain Behav Evol

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In many species, seasonal variation in grouping behavior is widespread, with shifts towards territoriality in the breeding season and grouping in the winter. Compared to the hormonal and neural mechanisms of seasonal territorial aggression, the mechanisms that promote seasonal grouping have received little attention. We collected brains in spring and winter from wild-caught males of two species of emberizid sparrows that seasonally flock (the field sparrow, Spizella pusilla, and the dark-eyed junco, Junco hyemalis) and two species that do not seasonally flock (the song sparrow, Melospiza melodia, and the eastern towhee, Pipilo erythrophthalmus). We used receptor autoradiography to quantify seasonal plasticity in available binding sites for three neuropeptides known to influence social behavior. We examined binding sites for ¹²⁵I-vasoactive intestinal polypeptide (VIP), ¹²⁵I-sauvagine (SG, a ligand for corticotropin-releasing hormone receptors) and ¹²⁵I-ornithine vasotocin analog (OVTA, a ligand for the VT3 nonapeptide). For all species and ligands, brain areas that exhibited a seasonal pattern in binding density were characterized by a winter increase. Compared to nonflocking species, seasonally flocking species showed different binding patterns in multiple brain areas. Furthermore, we found that winter flocking was associated with elevated winter ¹²⁵I-VIP binding density in the medial amygdala, as well as ¹²⁵I-VIP and ¹²⁵I-OVTA binding density in the rostral arcopallium. While the functional significance of the avian rostral arcopallium is unclear, it may incorporate parts of the pallial amygdala. Our results point to this previously undescribed area as a likely hot spot of social modulation.

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PAC1 receptors in chick cerebral cortex: characterization by binding of pituitary adenylate cyclase-activating polypeptide, [125I]-PACAP27

Cited by 14 publications

References 23 publications

Neuropeptide binding reflects convergent and divergent evolution in species-typical group sizes

Neuropeptide binding reflects convergent and divergent evolution in species-typical group sizes

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

Seasonal Variation in Group Size Is Related to Seasonal Variation in Neuropeptide Receptor Density

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