PACAP Regulation of Inflammatory and Free Radical Networks in Neuronal and Nonneuronal Diseases

Ohtaki, Hirokazu; Shioda, Seiji

doi:10.1007/978-3-319-35135-3_39

Cited by 3 publications

(4 citation statements)

References 96 publications

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“…However, the involvement of VPAC receptors also seems to be important, mainly conveying anti-inflammatory actions of the peptide. Via receptorial mechanisms, PACAP stimulates cAMP/PKA- (cyclic adenosine monophosphate/protein kinase A) mediated signaling, and also PI3K-pathways (phosphoinositol 3 kinase) and calcium-regulated mechanisms [ 27 , 29 ]. In addition, PACAP transactivates growth factor-related pathways [ 30 ] and penetrates the cell membrane directly, through receptor-independent uptake [ 31 ].…”

Section: General Overviewmentioning

confidence: 99%

Review on PACAP-Induced Transcriptomic and Proteomic Changes in Neuronal Development and Repair

Rivnyak

Kiss

Tamás

et al. 2018

IJMS

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Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with widespread occurrence and diverse biological effects. Among its several different effects, of special importance is the action of PACAP on neuronal proliferation, differentiation and migration, and neuroprotection. The neuroprotective mechanism of PACAP is both direct and indirect, via neuronal and non-neuronal cells. Several research groups have performed transcriptomic and proteomic analysis on PACAP-mediated genes and proteins. Hundreds of proteins have been described as being involved in the PACAP-mediated neuroprotection. In the present review we summarize the few currently available transcriptomic data potentially leading to the proteomic changes in neuronal development and protection. Proteomic studies focusing on the neuroprotective role of PACAP are also reviewed and discussed in light of the most intriguing and promising effect of this neuropeptide, which may possibly have future therapeutic potential.

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Section: General Overviewmentioning

confidence: 99%

Review on PACAP-Induced Transcriptomic and Proteomic Changes in Neuronal Development and Repair

Rivnyak

Kiss

Tamás

et al. 2018

IJMS

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“…Unfortunately, data available in literature regarding vitamin's D influence on PACAP are limited. Nevertheless, PACAP relation with inflammatory processes and obesity-related metabolic changes has been previously described [99,100]. It is expressed both in the peripheral and central nervous systems.…”

Section: Discussionmentioning

confidence: 99%

Impact of Vitamin D Supplementation on Inflammatory Markers’ Levels in Obese Patients

Wiciński

Ozorowski

Wódkiewicz

et al. 2021

CIMB

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In view of research suggesting a possible beneficial impact of vitamin D on systemic inflammatory response, the authors decided to investigate an influence of vitamin D supplementation on serum levels of certain inflammatory markers in obese patients. The current study included such biomarkers as interleukin-6 (IL-6), pituitary adenylate cyclase-activating peptide (PACAP), advanced oxidation protein products (AOPP), C-X3-C Motif Chemokine Ligand 1 (CX3CL1), monocyte chemoattractant protein-1 (MCP-1), and nitric oxide (NO). The measurements were performed with the ELISA method before and after 3-month-long supplementation of 2000 IU of vitamin D orally. The results showed that the therapy did not induce any statistically significant changes in serum levels of MCP-1, IL-6, CX3CL1, and PACAP. The supplementation was related to a significant increase in measurements of NO and AOPP levels, although the correlation analysis between vitamin D concentration after its supplementation and the concentration of the molecular parameters did not show significant relation. In conclusion, our study seems to contradict certain aspects of findings available in the literature regarding the vitamin D’s impact.

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“…By binding to receptors, PACAP triggers phospholipase C (PLC) and adenylate cyclase (AC), or calcium-regulated mechanisms. Furthermore, it can induce the trans-activation of growth-factor-related pathways [36,37] (Figure 3). During peripheral nerve regeneration, many macrophages infiltrate into nerve damaged area [26].…”

Section: Overview Of Pacap and Its Receptorsmentioning

confidence: 99%

“…By binding to receptors, PACAP triggers phospholipase C (PLC) and adenylate cyclase (AC), or calcium-regulated mechanisms. Furthermore, it can induce the trans-activation of growth-factor-related pathways [36,37] (Figure 3). The Null, Hop1, and Hop2 isoforms induce the activation of both PLC and AC, whereas the Hip variant triggers only AC.…”

Section: Overview Of Pacap and Its Receptorsmentioning

confidence: 99%

Effects of PACAP on Schwann Cells: Focus on Nerve Injury

Maugeri

D’Amico

Musumeci

et al. 2020

IJMS

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Schwann cells, the most abundant glial cells of the peripheral nervous system, represent the key players able to supply extracellular microenvironment for axonal regrowth and restoration of myelin sheaths on regenerating axons. Following nerve injury, Schwann cells respond adaptively to damage by acquiring a new phenotype. In particular, some of them localize in the distal stump to form the Bungner band, a regeneration track in the distal site of the injured nerve, whereas others produce cytokines involved in recruitment of macrophages infiltrating into the nerve damaged area for axonal and myelin debris clearance. Several neurotrophic factors, including pituitary adenylyl cyclase-activating peptide (PACAP), promote survival and axonal elongation of injured neurons. The present review summarizes the evidence existing in the literature demonstrating the autocrine and/or paracrine action exerted by PACAP to promote remyelination and ameliorate the peripheral nerve inflammatory response following nerve injury.

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PACAP Regulation of Inflammatory and Free Radical Networks in Neuronal and Nonneuronal Diseases

Cited by 3 publications

References 96 publications

Review on PACAP-Induced Transcriptomic and Proteomic Changes in Neuronal Development and Repair

Review on PACAP-Induced Transcriptomic and Proteomic Changes in Neuronal Development and Repair

Impact of Vitamin D Supplementation on Inflammatory Markers’ Levels in Obese Patients

Effects of PACAP on Schwann Cells: Focus on Nerve Injury

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