Paclitaxel-loaded multifunctional nanoparticles for the targeted treatment of glioblastoma

Ganipineni, Lakshmi Pallavi; Ucakar, Bernard; Joudiou, Nicolas; Riva, Raphaël; Jérôme, Christine; Gallez, Bernard; Danhier, Fabienne; Préat, Véronique

doi:10.1080/1061186x.2019.1567738

Cited by 42 publications

(23 citation statements)

References 48 publications

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“…In a recent study, Ucakar B. et al [34] found no significant difference between the brain accumulation of T80-coated and uncoated SPION-paclitaxel PNP in an orthotopic GBM model. However, in a subsequent study by the same authors [34,35], the magnetic targeting was found to enhance the brain accumulation of these NP, their antitumor efficacy and the survival rate. A significant prolongation in the survival rates of mice was obtained using a longer targeting time (4h vs. 1h), a stronger magnet (1.4 T vs. 0.4 T) and a larger number of doses (6 vs. 2).…”

Section: Survival Ratementioning

confidence: 98%

SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics

Luque-Michel

Lemaire

Blanco-Prieto

2021

Drug Deliv. and Transl. Res.

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Glioma is a type of cancer with a very poor prognosis with a survival of around 15 months in the case of glioblastoma multiforme (GBM). In order to advance in personalized medicine, we developed polymeric nanoparticles (PNP) loaded with both SPION (Superparamagnetic Iron Oxide Nanoparticles) and doxorubicin (DOX). The former being used for its potential to accumulate the PNP in the tumor under a strong magnetic field and the later for its therapeutic potential. The emulsion solvent and evaporation method was selected to develop monodisperse PNP with high loading efficiency in both SPION and DOX.Once injected in mice, a significant accumulation of the PNP was observed within the tumoral tissue under static magnetic field as observed by MRI leading to a reduction of tumor growth rate.

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Section: Survival Ratementioning

confidence: 98%

SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics

Luque-Michel

Lemaire

Blanco-Prieto

2021

Drug Deliv. and Transl. Res.

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“…Current chemotherapy often leaves debilitating and life altering side effects since most drugs on the market that target the rapidly dividing cancer cells also inadvertently damage cells that are vital for normal life processes (Rizvi and Saleh, 2018). Actively targeting PLGA nanoparticles are able to circumvent this; Moku et al (2019) have shown increased drug loading and efficacy against lung cancer by using transactivator of transcription (TAT) peptide ligands to target mesenchymal stem cells while Ganipineni et al (2019) found that magnetically targeted paclitaxel-and SPIO-loaded PLGA-based nanoparticles effected increased cellular uptake in glioblastoma cells compared to the non-targeted carriers. Another type of nanoparticle targeting is the use of 'smart' carriers that are engineered to respond to a stimulus (Kapoor et al, 2015).…”

Section: Actively Targeted Chemotherapeuticsmentioning

confidence: 99%

The Design of Poly(lactide-co-glycolide) Nanocarriers for Medical Applications

Essa

Kondiah

Choonara

et al. 2020

Front. Bioeng. Biotechnol.

166

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Polymeric biomaterials have found widespread applications in nanomedicine, and poly(lactide-co-glycolide), (PLGA) in particular has been successfully implemented in numerous drug delivery formulations due to its synthetic malleability and biocompatibility. However, the need for preconception in these formulations is increasing, and this can be achieved by selection and elimination of design variables in order for these systems to be tailored for their specific applications. The starting materials and preparation methods have been shown to influence various parameters of PLGA-based nanocarriers and their implementation in drug delivery systems, while the implementation of computational simulations as a component of formulation studies can provide valuable information on their characteristics. This review provides a critical summary of the synthesis and applications of PLGA-based systems in bio-medicine and outlines experimental and computational design considerations of these systems.

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“…Gold nanoparticles (2 nm) that were coated with functional derivatives of thiolated PEG have shown invisibility towards the immune system provided by PEG [106], but also enabled attaching other moieties to provide specific targeting. The surface of the nanocarriers was thus modified with the ligand RGD-a peptide with a relatively high and specific affinity for the integrins overexpressed in tumor neovasculature [107,108]. A mice model of single-nodule lung adenocarcinoma [109] was used to establish which route of administration, either inhalation or intravenous delivery, would be more effective on adenocarcinoma targeting using the nanocarriers.…”

Section: Applications In Cancer Therapymentioning

confidence: 99%

Multifunctional Nanocarriers for Lung Drug Delivery

Pontes

Grenha

2020

Nanomaterials

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Nanocarriers have been increasingly proposed for lung drug delivery applications. The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of particular clinical situations is frequent. These include the surface engineering of the carriers by means of altering the material structure (i.e., chemical modifications), the addition of specific ligands so that predefined targets are reached, or even the tuning of the carrier properties to respond to specific stimuli. The devised strategies are mainly directed at three distinct areas of lung drug delivery, encompassing the delivery of proteins and protein-based materials, either for local or systemic application, the delivery of antibiotics, and the delivery of anticancer drugs—the latter two comprising local delivery approaches. This review addresses the applications of nanocarriers aimed at lung drug delivery of active biological and pharmaceutical ingredients, focusing with particular interest on nanocarriers that exhibit multifunctional properties. A final section addresses the expectations regarding the future use of nanocarriers in the area.

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Paclitaxel-loaded multifunctional nanoparticles for the targeted treatment of glioblastoma

Cited by 42 publications

References 48 publications

SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics

SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics

The Design of Poly(lactide-co-glycolide) Nanocarriers for Medical Applications

Multifunctional Nanocarriers for Lung Drug Delivery

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