Paclitaxel loaded transfersomal vesicular drug delivery for the treatment of melanoma skin cancers

Raahulan, Sivarajakumar; Sanapalli, Bharat Kumar Reddy; Karri, Veera Venkata Satyanarayana Reddy

doi:10.26452/ijrps.v10i4.1569

Cited by 13 publications

(4 citation statements)

References 5 publications

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“…This is due to the ability of Span-80 to entrap the drug in a small multilamellar vesicle, allowing high entrapment efficacy. Lastly, transfersomal gel was prepared by using carbopol 940 mixed with transfersome solution, and the resulting gel formed had a pH of 6.8, which could avoid the risk of irritation when applying the gel on skin surface [91]. From this study, it was proven that transfersome can entrap PTX at a high level for the treatment of melanoma skin cancer.…”

Section: Transfersomesmentioning

confidence: 92%

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Site-Specific Vesicular Drug Delivery System for Skin Cancer: A Novel Approach for Targeting

Pandey

Choudhury

Gorain

et al. 2021

Gels

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Skin cancer, one of the most prevalent cancers worldwide, has demonstrated an alarming increase in prevalence and mortality. Hence, it is a public health issue and a high burden of disease, contributing to the economic burden in its treatment. There are multiple treatment options available for skin cancer, ranging from chemotherapy to surgery. However, these conventional treatment modalities possess several limitations, urging the need for the development of an effective and safe treatment for skin cancer that could provide targeted drug delivery and site-specific tumor penetration and minimize unwanted systemic toxicity. Therefore, it is vital to understand the critical biological barriers involved in skin cancer therapeutics for the optimal development of the formulations. Various nanocarriers for targeted delivery of chemotherapeutic drugs have been developed and extensively studied to overcome the limitations faced by topical conventional dosage forms. A site-specific vesicular drug delivery system appears to be an attractive strategy in topical drug delivery for the treatment of skin malignancies. In this review, vesicular drug delivery systems, including liposomes, niosomes, ethosomes, and transfersomes in developing novel drug delivery for skin cancer therapeutics, are discussed. Firstly, the prevalence statistics, current treatments, and limitations of convention dosage form for skin cancer treatment are discussed. Then, the common type of nanocarriers involved in the research for skin cancer treatment are summarized. Lastly, the utilization of vesicular drug delivery systems in delivering chemotherapeutics is reviewed and discussed, along with their beneficial aspects over other nanocarriers, safety concerns, and clinical aspects against skin cancer treatment.

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Section: Transfersomesmentioning

confidence: 92%

“…Moreover, Raahulan et al studied the treatment of melanoma skin cancer by using PTX-loaded transfersomes [91]. A conventional rotary vacuum evaporator was used to prepare the transfersomes at different ratios in which the ratio of PC:Span-80 is in the range of 95-80:05-20% w/w.…”

Section: Transfersomesmentioning

confidence: 99%

Site-Specific Vesicular Drug Delivery System for Skin Cancer: A Novel Approach for Targeting

Pandey

Choudhury

Gorain

et al. 2021

Gels

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“…The permeation of cytotoxic moieties in the tranferosomal system can improve skin cancer treatment. Another investigation by Sivarajakumar et al [137] prepared the paclitaxel-loaded transfersomal vesicular systems to enhance the delivery of drugs at the site of skin cancer cells by improving the permeation through the skin. The results suggested that optimized transfersomes had a flux of 6.68 ± 0.46 and a percent drug retention of (0.79 ± 0.05) through the skin of mice.…”

Section: Transferosomesmentioning

confidence: 99%

Exploring Nanocarriers as Treatment Modalities for Skin Cancer

Adnan,

Akhter,

Afzal

et al. 2023

Molecules

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Cancer is a progressive disease of multi-factorial origin that has risen worldwide, probably due to changes in lifestyle, food intake, and environmental changes as some of the reasons. Skin cancer can be classified into melanomas from melanocytes and nonmelanoma skin cancer (NMSC) from the epidermally-derived cell. Together it constitutes about 95% of skin cancer. Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (CSCC) are creditworthy of 99% of NMSC due to the limited accessibility of conventional formulations in skin cancer cells of having multiple obstacles in treatment reply to this therapeutic regime. Despite this, it often encounters erratic bioavailability and absorption to the target. Nanoparticles developed through nanotechnology platforms could be the better topical skin cancer therapy option. To improve the topical delivery, the nano-sized delivery system is appropriate as it fuses with the cutaneous layer and fluidized membrane; thus, the deeper penetration of therapeutics could be possible to reach the target spot. This review briefly outlooks the various nanoparticle preparations, i.e., liposomes, niosomes, ethosomes, transferosomes, transethosomes, nanoemulsions, and nanoparticles technologies tested into skin cancer and impede their progress tend to concentrate in the skin layers. Nanocarriers have proved that they can considerably boost medication bioavailability, lowering the frequency of dosage and reducing the toxicity associated with high doses of the medication.

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“…The results show that including the vesicles in the gel improves the ability to control release and improve skin permeation. The Carbopol-based gel was used as a vehicle for transferosomes loaded with 5-FU [141], paclitaxel [142], methotrexate [143], tofacitinib [144], tamoxifen citrate [145], and others. An interesting study was presented by Shamim et al, which includes carvedilol in transferosomes for topical administration to prevent UV-induced skin cancer [146].…”

Section: Nanovesiclesmentioning

confidence: 99%

Gel Formulations for Topical Treatment of Skin Cancer: A Review

Slavkova

Tzankov

Popova

et al. 2023

Gels

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Skin cancer, with all its variations, is the most common type of cancer worldwide. Chemotherapy by topical application is an attractive strategy because of the ease of application and non-invasiveness. At the same time, the delivery of antineoplastic agents through the skin is difficult because of their challenging physicochemical properties (solubility, ionization, molecular weight, melting point) and the barrier function of the stratum corneum. Various approaches have been applied in order to improve drug penetration, retention, and efficacy. This systematic review aims at identifying the most commonly used techniques for topical drug delivery by means of gel-based topical formulations in skin cancer treatment. The excipients used, the preparation approaches, and the methods characterizing gels are discussed in brief. The safety aspects are also highlighted. The combinatorial formulation of nanocarrier-loaded gels is also reviewed from the perspective of improving drug delivery characteristics. Some limitations and drawbacks in the identified strategies are also outlined and considered within the future scope of topical chemotherapy.

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Paclitaxel loaded transfersomal vesicular drug delivery for the treatment of melanoma skin cancers

Cited by 13 publications

References 5 publications

Site-Specific Vesicular Drug Delivery System for Skin Cancer: A Novel Approach for Targeting

Site-Specific Vesicular Drug Delivery System for Skin Cancer: A Novel Approach for Targeting

Exploring Nanocarriers as Treatment Modalities for Skin Cancer

Gel Formulations for Topical Treatment of Skin Cancer: A Review

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