Pädiatrische Dermatotherapie

Vogel, Margot; Brockow, Knut; Abeck, Dietrich

doi:10.1007/s00105-002-0473-2

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Glukokortikosteroide regulieren über verschiedene Mechanismen die Entzündungsreaktion der Haut herab. Neugeborene weisen eine höhere Dichte an Glukokortikosteroidrezeptoren auf [24]. Neben den bekannten lokalen Nebenwirkungen [25 -27].…”

Section: Verschiedene Wirkstoffeunclassified

Topische Therapieverfahren im Kindesalter

Wagner

2011

Akt Dermatol

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Zusammenfassung Die topische Therapie im Kindesalter weist gegen?ber der Dermatotherapie des Erwachsenen einige Besonderheiten auf. Die epidermale Barriereschicht entspricht bereits beim reifen Neugeborenen zwar der des Erwachsenen, jedoch bestehen Unterschiede in der Absorption, Metabolisierung und Elimination von Wirkstoffen. Die folgende ?bersicht soll eine Hilfestellung bei der Auswahl topischer Externa f?r die Basistherapie sowie bei der Anwendung von Hilfs- und Wirkstoffen im Kindesalter bieten.

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Section: Verschiedene Wirkstoffeunclassified

Topische Therapieverfahren im Kindesalter

Wagner

2011

Akt Dermatol

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“…It can result in an up to 2.7 times higher systemic exposure [2, 5, 6], entailing a risk of intoxication that should not be taken lightly. Severe side effects have been associated with various substances including hexachlorophene, salicylic acid, and disinfectants containing alcohol and phenol [7, 8]. Intoxication can result from not only the topical medication itself, but also interactions with other systemically administered drugs.…”

Section: Physiology Of Pediatric Skin Pharmacokinetics and Pharmacodmentioning

confidence: 99%

Special features of topical and systemic dermatologic therapy in children

Lukas

Wolf²,

Fölster‐Holst

2006

J Deutsche Derma Gesell

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Summary Since children differ greatly from adults in terms of physiology and pathophysiology, which in turn influences pharmacokinetics and pharmacodynamics, pediatric clinical trials on the effectiveness and safety of drugs must be supported. Such studies are still lacking. To avoid excluding pediatric patients from the benefit of optimal treatment, treatment strategies for children are often derived from trials with adult patients. Pediatric prescribing is also assisted by years of experience in the use of drugs and empirical data found in the literature. This article discusses typical side effects that can occur with pediatric topical and systemic drug use. Salicylic acid and lindane intoxication are discussed as are Reye syndrome after taking acetylsalicylic acid to treat viral infection. Additional examples and tables listing drugs often used in pediatric dermatology as well as general information on prescribing off‐label pharmaceuticals should help children with skin disorders benefit from effective and tolerable treatment.

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Pruritus im Kindesalter

et al. 2004

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From the clinician's point of view, pruritus in children is quite frequent. It mainly occurs along with dermatoses but rarely with systemic diseases such as renal and liver failure or with genetic disorders. Mostly, it appears in the setting of atopic dermatitis (AD). Other frequent differential diagnoses comprise e.g. scabies, impetigo, varicella, tinea, urticaria, mastocytosis and psoriasis. In children, pruritus is most often associated with severe scratching leading to artefacts. This group of patients requires a therapeutical regimen of its own. The use of topical and systemic treatments depends on the underlying aetiology of pruritus and the stage and status of the skin. The physician has to consider that topically applied drugs may cause intoxication due to the different body volume/body surface proportion, especially in newborns and infants. The dosages of systemic drugs need to be adapted in children and UV phototherapy should be performed with caution due to possible longterm photo damage of the skin. Physicians feel more insecurity treating pruritus in children, especially when systemic treatments are taken into consideration. We want to highlight the major aetiologies of pruritus in children and point out the cornerstones of antipruritic therapy in this challenging group of patients in recognition of our own clinical experiences and the current literature.

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Pädiatrische Dermatotherapie

Cited by 3 publications

References 23 publications

Topische Therapieverfahren im Kindesalter

Topische Therapieverfahren im Kindesalter

Special features of topical and systemic dermatologic therapy in children

Pruritus im Kindesalter

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