Paederia foetida Linn. leaf extract: an antihyperlipidemic, antihyperglycaemic and antioxidant activity

Abstract

BackgroundThe primary objective of the present investigation is to evaluate the antidiabetic, antihyperlidemic and antioxidant activity of the methanolic extract of the Paederia foetida Linn. (PF) leaf extract in the streptozotocin induced diabetic rats.MethodsSingle intraperitoneal injection (IP) of streptozotocin (60 mg/kg body weight) was used for induction of diabetes is swiss albino (wistar strain) rats. The induction of diabetes was confirmed after 3 days as noticing the increase in blood sugar level of tested rats. PF at a once a daily dose of 100 mg/kg, 250 mg/kg, 500 mg/kg, p.o. along with glibenclamide 10 mg/kg, p.o. was also given for 28 days. On the 28th day rats from all the groups fasted overnight fasted and the blood was collected from the puncturing the retro orbit of the eye under mild anesthetic condition. There collected blood sample was used to determine the antihyperlipidemic, hypoglycemic and antioxidant parameters.ResultsThe oral acute toxicity studies did not show any toxic effect till the dose at 2000 mg/kg. While oral glucose tolerance test showed better glucose tolerance in tested rats. The statistical data indicated that the different dose of the PF significantly increased the body weight, hexokinase, plasma insulin, high density lipoprotein cholesterol, superoxide dismutase, catalase and glutathione peroxides. It also decreases the level of fasting blood glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, malonaldehyde, glucose-6-phosphate, fructose-1-6-biphosphate and glycated hemoglobin in STZ induced diabetic rats. The histopathology of STZ induce diabetic rats, as expected the test dose of PF extract considerably modulates the pathological condition of various vital organ viz. heart, kidney, liver, pancreas as shown in the histopathology examinations.ConclusionsOur investigation has clearly indicated that the leaf extract of Paederia foetida Linn. showed remarkable antihyperglycemic activity due to its possible systematic effect involving in the pancreatic and extra pancreatic mechanism. Forever, the antihyperlipidemic activity was exerted possible by lowering the higher level of lipid profile and decreasing the intercalated disc space in the heart. The antioxidant activity of extract was due to inhibition of lipid peroxidation and increasing the SOD, GPx and CAT. It was corroborate that the extract shown the Paederia foetida Linn leaves potential to be act as antidiabetic, antihyperlipidemic and antioxidant properties.

In vitro propagation by axillary shoot proliferation, assessment of antioxidant activity, and genetic fidelity of micropropagated Paederia foetida L.

“…Hence, the present study concludes that even the leaves of micropropagated P. foetida can be used as a source of lead Oral administration of different doses (100, 250, and 500 mg) of methanolic leaf extracts of naturally grown P. foetida significantly improved the level of superoxide dismutase, catalase, and glutathione peroxidase in induced diabetic group of rats [3]. Hence, antioxidant treatment may be beneficial for diabetic patient, and P. foetida plant will be a major help in this regard [3]. Antioxidant potential by DPPH radical scavenging activity of methanolic leaf extracts of naturally grown P. foetida has also been reported by Nayak et al [19], and antioxidant activity by ABTS radical cation assay of the methanol extract of the whole plant of P. foetida has been reported by Osman et al [6].…”

“…Cellular damage or oxidative injury arising from free radicals of ROS now appears to be one of the key factors for a number of human disease, such as inflammation, cancer, atherosclerosis, neurodegenerative disease, and aging [15,37]. Hence, the present study concludes that even the leaves of micropropagated P. foetida can be used as a source of lead Oral administration of different doses (100, 250, and 500 mg) of methanolic leaf extracts of naturally grown P. foetida significantly improved the level of superoxide dismutase, catalase, and glutathione peroxidase in induced diabetic group of rats [3]. Hence, antioxidant treatment may be beneficial for diabetic patient, and P. foetida plant will be a major help in this regard [3].…”

“…The plant is widely used by the tribal people of India for the treatment of gastrointestinal disorder, stomachache, enterosis, flatulence, gastromegaly, piles, rheumatism, ulcers, and toothache [2,3]. This species also shows antiinflammatory [2,4], anticancerous [2], and antidiarrheal properties [2,5].…”

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“…4, daily oral administration of IL8 sprout extracts for the 21 days of experimental period significantly improved plasma insulin levels and decreased blood glucose levels as compared to their seed extracts. In one of the recent studies, fenugreek seeds have been reported to significantly increase the reduced serum insulin levels of STZ-induced diabetic rats, via stimulation of insulin secretion and regeneration of the β-cells of the pancreas 25 . It is proposed that the possible antihyperglycemic mechanism involved by fenugreek sprout extracts may be either due to their insulin emission from the β-cells, followed by improved glucose transportation or consumption 26 .…”

Therapeutic effect of umbelliferon-α-D-glucopyranosyl-(2I→1II)-α-D-glucopyranoside on adjuvant-induced arthritic rats

“…Different doses of UFD were administered to the test groups in graded doses ranging up to 100 mg/kg. The animals were continuously observed for 2 h for the following (Kumar et al 2014;Ghosh 1984) 3. Autonomic profile: urination and defecation.…”