Paediatric cerebral palsy prevalence and high-risk factors in Henan province, Central China

Yuan, Junying; Wang, Jun; Ma, Jieqiong; Zhu, Dengna; Zhang, Zhenhuan; Li, Jianan

doi:10.2340/16501977-2486

Cited by 16 publications

(13 citation statements)

References 21 publications

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“…18 We found GDM is not one of significant factors but this result is not consistent with other studies that shows women who suffer from GDM during pregnancy were 1.9 times more likely to have children with CP compared to mothers who did not. 11,19,16 TORCH infection can attack pregnant women and fetuses in the womb. TORCH is caused by the parasite Toxoplasma gondii, rubella virus, herpes simplex virus type 1 and type 2.…”

Section: Resultsmentioning

confidence: 99%

Prenatal Risk Factors on Children’s Cerebral Palsy Case at RSIA Bunda Jakarta

Lariza

Artanti

Hidayat

2021

BHSJ

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Introduction: Cerebral Palsy is a disease that is less recognized by the public due to the lack of information related to CP in Indonesia. Aims to analyze prenatal risk factors that influence the evidence of CP RSIA Bunda Jakarta.Methods: This study was conducted in April 2021 at RSIA Bunda Jakarta, an analytical study with a case control design. The sample in this study were 124 respondents from mothers of children who underwent outpatient treatment at the RSIA Bunda Jakartaas cases and controls. each taken by simple random sampling technique. Data were analyzed using the test chi-square to analyze the relationship between variables.Results: The results of statistical analysis showed that the risk factors associated with the incidence of CP were maternal age (p= 0.00; OR= 13.25; 95% CI= 2.93-59.93), preeclampsia (p= 0.00; OR= 2,06; 95% CI= 1,71-2,48), TORCH (p= 0.00; OR= 2.40; 95% CI= 1.92-3.01), and antenatal care (p= 0.00; OR= 41.2; 95% CI= 5.45-317.0). Conclusion: Risk factors affecting the occurrence of CP in children include age <20 or ≥35 years, preeclampsia, TORCH infection and antenatal care visits <4 times. It is necessary to increase intervention programs at various levels of health services to diagnose and prevent the occurrence of cerebral palsy in children so that optimal maternal and child health is achieved. and further research is needed to determine other risk factors that can cause CP in children such as perinatal and postnatal risk factors.

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Section: Resultsmentioning

confidence: 99%

Prenatal Risk Factors on Children’s Cerebral Palsy Case at RSIA Bunda Jakarta

Lariza

Artanti

Hidayat

2021

BHSJ

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“…Esto afecta a los países en desarrollo, debido a que el mantenimiento de estos niños con discapacidades resultan en gastos, lo cuales no siempre pueden ser solventados en su totalidad, ya que los más afectados en la mayor parte de los casos son las personas de bajos recursos, como lo demuestra un estudio realizado por Gwatkin 17 en donde se evaluaron 56 casos, determinándose que los niños provenientes de familias de bajos recursos aumentan sus impedimentos cognitivos, contribuidos por el ambiente de pobreza al que están expuestos 18 . La prevalencia de retraso global del neurodesarrollo puede deberse a las características sociodemográficas de la población que es atendida, debido a la relación de dicha patología con el entorno familiar y ambiental al cual es expuesto el infante causando los efectos deletéreos en la adquisición de los hitos de desarrollo [19][20][21][22][23][24][25][26][27][28][29][30] .…”

Section: Discussionunclassified

“…Cabe destacar que el retraso global del neurodesarrollo, la parálisis cerebral y la discapacidad cognitiva fueron los trastornos del desarrollo más frecuente evidenciados, siendo este grupo de trastornos los que presentan mayor cantidad de factores de riesgo biológicos y ambientales que pueden ser modificados para disminuir su incidencia en la población, además de que los mismos guardan relación con las características sociodemográficas de la población [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] .…”

Section: Discussionunclassified

Prevalencia de los desórdenes del desarrollo en un hospital de 3er nivel de Santo Domingo Norte, República Dominicana

Morban¹,

Colomé-Hidalgo²,

Torres³

2021

cysa

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Introducción: los desórdenes del desarrollo en pediatría son un conjunto de patologías cuya prevalencia ha aumentado en los últimos años, siendo estimada globalmente 13.3 % de la población mundial pediátrica. Material y métodos: se realizó un estudio de análisis descriptivo, de corte transversal y recolección de datos retrospectivo desde enero hasta septiembre del 2019 en la base de datos de consulta externa del Hospital Pediátrico Dr. Hugo Mendoza, con el objetivo de establecer la prevalencia de los desórdenes del desarrollo infantil. Resultados: la prevalencia de desórdenes del desarrollo fue de 21.7/1000 atendidos en el centro, donde prevaleció como causa la epilepsia. Conclusiones: la prevalencia de los desórdenes del desarrollo es de un 2.17 % de la población pediátrica, siendo el sexo más afectado el masculino, y el trastorno más frecuente la epilepsia.

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“…Cerebral palsy (CP), the leading cause of life-long disability in children [1], affects approximately 1 in 500 neonates with an estimated prevalence of 17 million people worldwide [2][3][4]. CP heavily burdens the families and society [5].…”

Section: Introductionmentioning

confidence: 99%

Spinal Tuina Improves Cognitive Impairment in Cerebral Palsy Rats through Inhibiting Pyroptosis Induced by NLRP3 and Caspase-1

Niu

Wang

Zhong

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Cerebral palsy (CP) is a severe cerebral disease with high mortality and morbidity, which leads to great challenges for the suffering children and their families. Hence, the need for the efficacious and safe treatments is urgent. As a physical therapy arising from traditional Chinese medicine (TCM), Tuina has shown multiple effects on various diseases, including cerebral palsy. Nevertheless, the detailed mechanisms of Tuina on CP remain unknown, which impedes its further clinical application. Herein, we explored the effects of Tuina on CP and its potential mechanisms. Thirty Sprague Dawley (SD) male rats were randomly divided into sham, model, and Tuina groups (model + Tuina). CP rat model was established by hypoxia-ischemia via permanent occlusion of left common carotid artery and hypoxia for 2.5 hours caused by anaerobic environment, which was subsequently followed by onset of Tuina treatment from postnatal day 7 (P7) to P49. After completion of Tuina treatment, the behavioral tests showed that Tuina treatment not only improved the retarded body weight and impaired motor balance function, but also ameliorated weakened learning and memory function of CP rats. Moreover, immunohistochemistry and western blot also revealed a reduced expression of NLRP3 inflammasome and corresponding pyroptosis-related molecules induced by NLRP3 in CP rats after Tuina treatment. Therefore, our study indicated that Tuina treatment may improve impaired neurocognitive function of CP rats, which was possibly realised via inhibiting NLRP3-induced pyroptosis.

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Paediatric cerebral palsy prevalence and high-risk factors in Henan province, Central China

Cited by 16 publications

References 21 publications

Prenatal Risk Factors on Children’s Cerebral Palsy Case at RSIA Bunda Jakarta

Prenatal Risk Factors on Children’s Cerebral Palsy Case at RSIA Bunda Jakarta

Prevalencia de los desórdenes del desarrollo en un hospital de 3er nivel de Santo Domingo Norte, República Dominicana

Spinal Tuina Improves Cognitive Impairment in Cerebral Palsy Rats through Inhibiting Pyroptosis Induced by NLRP3 and Caspase-1

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