Background:The alternative device to close perimembranous ventricular septal defect (pmVSD) has been searched for better result, less complications and applicable for infants. However, the ideal device is still unavailable. We aimed to evaluate the effectiveness and outcome of transcatheter pmVSD closure using the KONAR-multi functional occluder (MFO).Methods: Clinical, procedural, follow-up data of pmVSD patients with symptom of heart failure or evidence of significant left to right shunt, growth failure, recurrent respiratory tract infection, and history of endocarditis who underwent transcatheter closure using the MFO were prospectively evaluated. Results:Between January 2016 and December 2017, there were complete records of 132 pmVSD children closed using MFO from eleven centers in Indonesia. The median of age was 4.5 (0.3-17.4) years; weight 14.8 (3.5-57) kg, defect size at the smallest part 3.4 (1.0-8.1) mm, flow ratio 1.6 (1.3-4.9), mean pulmonary artery pressure 18 (7-79) mmHg, fluoroscopy time 18 (3.8-91) and procedural time 75 (26-290) minutes. A retrograde approach was done in 41 (31%) patients. Procedures succeeded in first 2 Kuswiyanto et al.

Cattle bone ash contains high calcium and phosphor that can be used as foliar fertilizer. The foliar application requires particles whose size must be smaller than the stomatal size. The study is expected to increase the growth and the production of sweet corn by applying cattle bone ash to sweet corn through foliar application. The experiment was conducted in a complete randomized design with five treatments; without cattle bone ash application, 0.1 %, 0.2 %, 0.3%, and 0.4% of cattle bone ash concentration. Cattle bone ash dominated with particles smaller than stomatal size and contained high calcium, oxygen and phosphor with little of sodium and magnesium. The result showed that 0.3% application of micro cattle bone ash could enhance leaves area, root dry weight, net assimilation rate, ear weight, and 100 kernels weight of sweet corn.

Intermittent irrigation can save water use in rice cultivation, which is essential, especially during the dry season. This study aims to improve the physiology of the growth and yield of rice in various varieties by applying intermittent irrigation. The research was conducted from February to June 2019 in the experimental field of the Faculty of Agriculture, Universitas Muhammadiyah Yogyakarta. The research used a factorial experimental method 3 x 4 strip plots arranged in a Completely Randomized Block Design with three replications. The factor I rice varieties consist of Cempo Merah, Inpari 23, Sintanur, and Inpari 42. Factor II is the irrigation system consisting of continuous flooding, ten days of inundation, five days of drying, seven days of inundation, and three days of drying. There is an interaction between types of irrigation and rice varieties on the number of tillers. In Ten-day watering five-day drying, Sintanur and Inpari 42 variety produce more tillers than Inpari 23. On Seven days watering five-day drying, the Inpari 42 variety produces more tillers than Inpari 23. There are the differences in the responses of various rice varieties to the Specific Leaf Weight and yield. Specific Leaf Weight rice Cempo Merah varieties are higher than, Inpari 23, Sintanur and Inpari 42. Rice yield of Inpari 42 variety is higher than Cempo Merah, Inpari 23, and Sintanur varieties. Roots with watering seven days watering, three days of drying is longer than Ten-day watering five-day drying. Roots with watering Ten-day watering five-day drying is longer than conventional.

Impaired nutritional status is a frequent complication of congenital heart disease (CHD). Non cyanotic congenital heart disease (NC-CHD) have problem with lung overfl ow and heart failure. Consequences of Cyanotic congenital heart disease (C-CHD) are decrease pulmonary blood fl ow and prolong hypoxia. These conditions can have eff ect on nutritional status and outcome of surgery. This study aimed to compare anthropometric profi les of children with C-CHD and NC-CHD. Cross-sectional study conducted in 66 children, age 3 months until 5 years old who met inclusion criteria in Pediatric Cardiology Outpatient Unit Dr. Soetomo Hospital Surabaya in November 2012. A total of 66 children, consisted of 26 children with C-CHD and 40 children NC-CHD included in study. We measure weight, length/height, head circumference, upper arm circumference, and skin fold thickness. We used Chi Square test for statistical analysis with Confi dence Interval 95%. Mean age of both groups was 27.82 ± 16.63 months. Majority of NC-CHD was Ventricular Septal Defect (28.6%) and C-CHD was Tetralogy of Fallot (21.4%). There were no signifi cant diff erence from weight for age, length for age weight for length, head circumference for age, mid upper arm circumference for age, mid upper arm circumference for age, and skin fold thickness for age between children with C-CHD and NC-CHD (p= 0.80; 0.98;0.54 0.29; 0.80; 0.53 respectively). There were no diff erence in anthropometric profi les among children with cyanotic congenital heart disease and non-cyanotic congenital heart disease in this study.

Background: Daunorubicine, a type of anthracycline, is a drug commonly used in cancer chemotherapy that increases survival rate but consequently compromises with cardiovascular outcomes in some patients. Thus, preventing the early progression of cardiotoxicity is important to improve the treatment outcome in childhood acute lymhoblastic leukemia (ALL). Objective: The present study aimed to identify the risk factors in anthracycline-induced early cardiotoxicity in childhood ALL. Methods: This retrospective study was conducted by observing ALL-diagnosed children from 2014 to 2019 in Dr. Soetomo General Hospital. There were 49 patients who met the inclusion criteria and were treated with chemotherapy using Indonesian Childhood ALL Protocol 2013. Echocardiography was performed by pediatric cardiologists to compare before and at any given time after anthracycline therapy. Early cardiotoxicity was defined as a decline of left ventricle ejection fraction (LVEF) greater than 10% with a final LVEF < 53% during the first year of anthracycline administration. Risk factors such as sex, age, risk stratification group, and cumulative dose were identified by using multiple logistic regression. Diagnostic performance of cumulative anthracycline dose was evaluated by receiver operating characteristic (ROC) curve. Results: Early anthracycline-induced cardiotoxicity was observed in 5 out of 49 patients. The median cumulative dose of anthracycline was 143.69±72.68 mg/m 2 . Thirty-three patients experienced a decreasing LVEF. The factors associated with early cardiomyopathy were age of ≥ 4 years (PR= 1.128; 95% CI: 1.015-1.254; p= 0.001), high risk group (PR= 1.135; 95% CI: 1.016-1.269; p= 0.001), and cumulative dose of ≥120 mg / m 2 (CI= 1.161; 95% CI:1.019-1.332). Conclusion: Age of ≥ 4 years, risk group, and cumulative dose of ≥120 mg/m 2 are significant risk factors for early cardiomyopathy in childhood ALL.