Background:The alternative device to close perimembranous ventricular septal defect (pmVSD) has been searched for better result, less complications and applicable for infants. However, the ideal device is still unavailable. We aimed to evaluate the effectiveness and outcome of transcatheter pmVSD closure using the KONAR-multi functional occluder (MFO).Methods: Clinical, procedural, follow-up data of pmVSD patients with symptom of heart failure or evidence of significant left to right shunt, growth failure, recurrent respiratory tract infection, and history of endocarditis who underwent transcatheter closure using the MFO were prospectively evaluated. Results:Between January 2016 and December 2017, there were complete records of 132 pmVSD children closed using MFO from eleven centers in Indonesia. The median of age was 4.5 (0.3-17.4) years; weight 14.8 (3.5-57) kg, defect size at the smallest part 3.4 (1.0-8.1) mm, flow ratio 1.6 (1.3-4.9), mean pulmonary artery pressure 18 (7-79) mmHg, fluoroscopy time 18 (3.8-91) and procedural time 75 (26-290) minutes. A retrograde approach was done in 41 (31%) patients. Procedures succeeded in first 2 Kuswiyanto et al.

Impaired nutritional status is a frequent complication of congenital heart disease (CHD). Non cyanotic congenital heart disease (NC-CHD) have problem with lung overfl ow and heart failure. Consequences of Cyanotic congenital heart disease (C-CHD) are decrease pulmonary blood fl ow and prolong hypoxia. These conditions can have eff ect on nutritional status and outcome of surgery. This study aimed to compare anthropometric profi les of children with C-CHD and NC-CHD. Cross-sectional study conducted in 66 children, age 3 months until 5 years old who met inclusion criteria in Pediatric Cardiology Outpatient Unit Dr. Soetomo Hospital Surabaya in November 2012. A total of 66 children, consisted of 26 children with C-CHD and 40 children NC-CHD included in study. We measure weight, length/height, head circumference, upper arm circumference, and skin fold thickness. We used Chi Square test for statistical analysis with Confi dence Interval 95%. Mean age of both groups was 27.82 ± 16.63 months. Majority of NC-CHD was Ventricular Septal Defect (28.6%) and C-CHD was Tetralogy of Fallot (21.4%). There were no signifi cant diff erence from weight for age, length for age weight for length, head circumference for age, mid upper arm circumference for age, mid upper arm circumference for age, and skin fold thickness for age between children with C-CHD and NC-CHD (p= 0.80; 0.98;0.54 0.29; 0.80; 0.53 respectively). There were no diff erence in anthropometric profi les among children with cyanotic congenital heart disease and non-cyanotic congenital heart disease in this study.

Latar belakang. Pengobatan utama limfomia limfoblastik akut (LLA) adalah kemoterapi.Sitostatik yang paling sering memberikan efek samping pada sistem kardiovaskuler adalahgolongan antrasiklin yaitu doksorubisin dan daunorubisin. Tanda awal kardiomiopatikarena antrasiklin adalah gangguan fungsi diastolik. Adanya gangguan fungsi ventrikeldapat dibuktikan dengan metode radionuklid dan ekokardiografi Doppler.Tujuan penelitian. Memperoleh data fungsi diastolik dan sistolik ventrikel kiri, dimensiventrikel kiri, dan status gizi pada anak dengan LLA pasca terapi daunorubisin.Metode. Penelitian cross sectional meneliti fungsi diastolik dan sistolik ventrikel kiripada 19 anak LLA pasca terapi daunorubisin. Sebagai kontrol penelitian 21 anak LLAtanpa terapi daunorubisin dan 18 anak sehat. Pemeriksaan fungsi dan dimensi ventrikelkiri dilakukan dengan pemeriksaan ekokardiografi 2D, M mode dan Doppler. Analisisstatistik hasil penelitian dilakukan dengan mempergunakan uji ANOVA dan Chi-square.Hasil. Terdapat 12 dari 19 anak pada kelompok studi dan 5 dari 21 anak pada kelompokkontrol LLA yang mengalami gangguan fungsi diastolik ventrikel kiri dengan pola penurunanrelaksasi. Pola penurunan relaksasi terdapat pada kardiomiopati hipertrofi maupunkardiomiopati dilatasi, hipertrofi ventrikel kiri karena berbagai sebab, penyakit jantungiskemik, preload yang menurun, dan afterload yang meningkat. Pada kelompok kontrolLLA juga sudah terdapat gangguan fungsi diastolik ventrikel kiri. Disamping daunorubisinterdapat faktor lain yang mempengaruhi fungsi diastolik ventrikel kiri, penyakitnya sendiridan obat-obat lain. Gangguan fungsi sistolik ventrikel kiri hanya didapatkan pada 1 anakkelompok studi. Hal ini disebabkan oleh dosis kumulatif daunorubisin yang masih relatifrendah dan follow up yang masih pendek. Tidak terdapat perubahan dimensi ventrikel kiripada kelompok studi dibandingkan kelompok kontrol; belum terjadi kardiomiopati yangberhubungan dengan dosis kumulatif yang tinggi dan penggunaan yang lama untuktimbulnya manifestasi klinis. Pada kelompok studi tidak didapatkan perbedaan yang bermaknaantara gizi dengan timbulnya gangguan fungsi diastolik.Kesimpulan. Pada anak dengan penyakit leukemia limfoblastik akut pasca terapidaunorubisin dosis kumulatif 120 mg/m2 telah mengalami gangguan fungsi diastolikventrikel kiri, sedangkan fungsi sistolik tidak terganggu. Dimensi ventrikel kiri tidakmengalami perubahan. Tidak terdapat perbedaan status gizi pada anak dengan fungsidiastolik ventrikel kiri terganggu.

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Introduction: Congenital Heart Disease (CHD) is the leading cause of death in the first year of life. One of the manifestations of CHD is upper respiratory infection (URI). In Indonesia, 90% of the acute respiratory infection is URI and it becomes the most common reason for children to go to emergency center. The aim of this study is to describe the profile of children with congenital heart disease and upper respiratory tract infection (URTI) in Dr. Soetomo General Hospital, Surabaya, based on sex, age, immunization status, social-economic status, and type of CHD. Methods: This descriptive study was done by collecting data using medical records and questionnaires from March 1st to 31st 2018. Results: Total number of the sample was 46 patients; 18 (39.1%) of them were male and 28 (60.9%) were female, with male to female ratio was 1:1.6. The most common age group (69.6%) was toddler (0-5 years old). The most common type of CHD was acyanotic (89.1%). Conclusion: Female patients had more (80%) severe URI than male patients. Patients with severe URI only occur in toddlers. Interestingly, 60% of patients with severe URI had complete immunization. Patients with severe URI had parents with moderate (60%) and low income (40%). There were 100% of patients with severe URI who had acyanotic CHD.