Paediatric giant cavernomas: report of three cases with a review of the literature

Shroff, Krishna; Deopujari, Chandrashekhar; Karmarkar, Vikram; Mohanty, Chandan

doi:10.1007/s00381-021-05286-6

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…Cerebral cavernous malformations (CCMs) have been variously called cryptic angioma, cavernous angioma, cavernous hemangioma, cavernoma, and “angiographically occult vascular malformations.” 1 2 3 They account for about 5 to 13% of intracranial vascular malformations and their population prevalence is 0.5%. 4 5 6 7 8 CCMs are the only vascular malformations known to form cysts.…”

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confidence: 99%

Cystic Cerebral Cavernous Malformations: Report of Five Cases and a Review of Literature

et al. 2023

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Introduction Cerebral cavernous malformations (CCMs) account for about 5 to 13% of intracranial vascular malformations. Cystic cerebral cavernous malformations (cCCMs) are a rare morphological variant and can cause diagnostic and therapeutic dilemmas. We describe our five such cases and review the existing literature on this entity. Methods A search of the PubMed database for cCCMs was done, and all articles in English emphasizing the reporting of cCCMs were selected. A total of 42 publications describing 52 cases of cCCMs were selected for analysis. Epidemiological data, clinical presentation, imaging features, the extent of resection, and outcome were analyzed. Radiation-induced cCCMs were excluded. We have also described five of our cases of cCCMs and reported our experience. Results The median age at presentation was 29.5 years. Twenty-nine patients had supratentorial lesions, 21 had infratentorial lesions, and 2 had lesions in both compartments. Among our four patients, three had infratentorial lesions, whereas one had a supratentorial lesion. Multiple lesions were seen in four patients. A majority (39) had symptoms of mass effect (75%), and 34 (65.38%) had raised intracranial pressure (ICP), whereas only 11 (21.15%) had seizures. Among our four operated patients, all of them had symptoms of mass effect, and two of them also had features of raised ICP. The extent of resection was gross total in 36 (69.23%), subtotal in 2 (3.85%), and not reported in 14 (26.93%). All four of our operated patients underwent gross total resection, but two of them underwent a second surgery. Of the 48 patients in whom the surgical outcome was reported, 38 improved (73.08%). One showed a transient worsening followed by improvement, one developed a worsening of the pre-existing focal neurological deficit (FND), two developed a new FND, and 5 had no improvement in their FNDs. Death occurred in one patient. All four of our operated patients improved after surgery, although three of them showed a transient worsening of FNDs. One patient is under observation. Conclusion cCCMs are rare morphological variants and can cause considerable diagnostic and therapeutic dilemmas. They should be considered in the differential diagnosis of any atypical cystic intracranial mass lesion. Complete excision is curative, and the outcome is generally favorable; although transient deficits may be seen.

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Section: Introductionmentioning

confidence: 99%

Cystic Cerebral Cavernous Malformations: Report of Five Cases and a Review of Literature

et al. 2023

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Giant Cavernous Malformation Mimicking an Infiltrative Intracranial Neoplasm in Children–Case Report and Systematic Review of the Literature

et al. 2023

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Giant cerebellar cavernous malformation in children: A case report and literature review

Akramov,

Nazarova,

Kurbanov

et al. 2024

J Cerebrovasc Endovasc Neurosurg

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Giant cerebellar cavernomas in children are rare and must be differentiated from hemorrhagic cerebellar tumors. The diagnosis and treatment of giant cerebellar cavernomas is challenging, but complete surgical resection can lead to favorable outcomes and complete neurological recovery in most cases. We present a case of eight months old baby who was diagnosed with a giant cavernoma resulting in secondary obstructive hydrocephalus with neuropsychiatric presentations. The patient underwent a paramedian craniotomy surgery with a suboccipital approach and complete surgical resection of the cavernoma was done. Over nine months of observation, the child showed improvement in their ability to walk and fully recovered from a neurological perspective. We also conducted a literature review to identify eleven cases of giant cerebellar cavernomas in children, including our case. The data were analyzed to determine the clinical features, treatment, and outcomes of giant cerebellar cavernomas in children.

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Paediatric giant cavernomas: report of three cases with a review of the literature

Cited by 3 publications

References 41 publications

Cystic Cerebral Cavernous Malformations: Report of Five Cases and a Review of Literature

Cystic Cerebral Cavernous Malformations: Report of Five Cases and a Review of Literature

Giant Cavernous Malformation Mimicking an Infiltrative Intracranial Neoplasm in Children–Case Report and Systematic Review of the Literature

Giant cerebellar cavernous malformation in children: A case report and literature review

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