2022
DOI: 10.1016/s2352-4642(22)00027-x
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Paediatric hospitalisations due to COVID-19 during the first SARS-CoV-2 omicron (B.1.1.529) variant wave in South Africa: a multicentre observational study

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Cited by 186 publications
(240 citation statements)
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“…Among hospitalised paediatric patients (aged ≤13 years) with a primary COVID-19 diagnosis, seizures were reported in 19 (31%) of 138 patients, with only a small number having comorbid conditions (eg, epilepsy [n=1] and cerebral palsy [n=1]) that explained the seizure manifestations. 4 In a separate multinational study of neurological manifestations by Fink and colleagues, 5 seizures were reported in 108 (8·5%) of 1278 children hospitalised with COVID-19. The study included patients from 30 centres across North and South America.…”
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confidence: 98%
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“…Among hospitalised paediatric patients (aged ≤13 years) with a primary COVID-19 diagnosis, seizures were reported in 19 (31%) of 138 patients, with only a small number having comorbid conditions (eg, epilepsy [n=1] and cerebral palsy [n=1]) that explained the seizure manifestations. 4 In a separate multinational study of neurological manifestations by Fink and colleagues, 5 seizures were reported in 108 (8·5%) of 1278 children hospitalised with COVID-19. The study included patients from 30 centres across North and South America.…”
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confidence: 98%
“…In The Lancet Child & Adolescent Health, a study by Jeané Cloete and colleagues, 4 published performed in Tshwane District of South Africa, found a rapid increase in paediatric COVID-19-related admissions to hospital (hereafter, hospitalisations) during the 6-week period from Oct 31 to Dec 11, 2021. The rapid increase in hospitalisations was accompanied by widespread community transmission of the omicron variant, as shown by COVID-19 surveillance data from multiple sources and genomic sequencing data.…”
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confidence: 99%
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“…But is Omicron more severe in children? In children, the fraction of SARS-CoV-2-positive cases admitted to hospital in South Africa doubled during the Omicron wave compared to in the Delta wave 8 , 9 . This seems to point to higher disease severity.…”
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confidence: 99%
“…1,2 Emerging evidence suggests that omicron causes less severe disease than previous variants of concern (VOC), probably due to lower virulence, infection-acquired immunity, and higher vaccination coverage. [3][4][5][6] However, its high transmissibility and ability to partially evade the immune response induced has been associated with a substantial increase in severe Covid-19 cases globally. 2 The absolute number of pediatric hospital admissions has also surpassed previous waves, 4,7,8 straining healthcare systems even further.…”
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confidence: 99%