Paediatric metanephric tumours: a clinicopathological and molecular characterisation

Jel, Dominique V.C. de; Hol, Janna A.; Ooms, Ariadne H.A.G.; Krijger, Ronald R. de; Jongmans, Marjolijn C.J.; Littooij, Annemieke S.; Drost, Jarno; Grotel, Martine van; Heuvel‐Eibrink, Marry M. van den

doi:10.1016/j.critrevonc.2020.102970

Cited by 12 publications

(18 citation statements)

References 43 publications

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“…It is treated with surgery only and has the same excellent prognosis as MN. 43 MAF occurs in children and young adults and exhibits a mixture of stromal elements (identical to those in MST) and well-defined areas of immature epithelium (tubules and papillae). 43 Finally, MA is more commonly found in adults than in children.…”

Section: Discussionmentioning

confidence: 99%

“…43 MAF occurs in children and young adults and exhibits a mixture of stromal elements (identical to those in MST) and well-defined areas of immature epithelium (tubules and papillae). 43 Finally, MA is more commonly found in adults than in children. It is usually small (up to 2 cm) and composed of monotonous small, closely packed tubules which show no mitoses.…”

Section: Discussionmentioning

confidence: 99%

“…MA may be difficult to distinguish from epithelial-predominant WT and there may be a close pathogenetic relationship. 43…”

Section: Discussionmentioning

confidence: 99%

“…Metanephric tumours include a spectrum of rare entities, including metanephric stromal tumour (MST), metanephric adenofibroma (MAF) and metanephric adenoma (MA). 43 Histologically, MST is a pure stromal tumour showing characteristic hypo-and hypercellular areas (resulting in a nodular appearance on low power view) (Figure 8a), concentric collarets of tumour around entrapped tubules and blood vessels which may show angiodysplasia.…”

Section: Metanephric Tumoursmentioning

confidence: 99%

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Renal tumours of childhood: A review

Vujanić¹,

Djuričić²

2022

Scripta Medica

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Renal tumours of childhood are rare, although they are one of the most common solid tumours in children. They include numerous entities, which have different clinical, histological, molecular biological and prognostic features, so their precise diagnosis and staging are critical for appropriate treatment. The most common is Wilms' tumour (WT) with ~80-85 % of all cases, whereas other entities including mesoblastic nephroma, clear cell sarcoma, rhabdoid tumour, renal cell carcinoma, metanephric tumours and others are very rare (2-4 % each) which explains why they represent a big diagnostic challenge for diagnostic pathologists. They are subclassified into three risk groups - low, intermediate and high - which have different treatments and prognosis. There are two big study groups which have different approaches but remarkable similar outcomes. The International Society of Paediatric Oncology approach (followed in most of the world) is based on preoperative chemotherapy, followed by surgery and further therapy, whereas the Children's Oncology Group approach (followed mainly in the United States and Canada) is based on primary surgery, followed by postoperative treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…MA may be difficult to distinguish from epithelial-predominant WT and there may be a close pathogenetic relationship. 43…”

Section: Discussionmentioning

confidence: 99%

Section: Metanephric Tumoursmentioning

confidence: 99%

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Renal tumours of childhood: A review

Vujanić¹,

Djuričić²

2022

Scripta Medica

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“…Since Bove et al ( 3 ) first discovered MA in 1979, only a few hundred cases have been reported, and most of them are adults. The incidence of MA in children is extremely rare, with dozens of cases reported at present, and only less than five cases in children under 2 years old ( 4 – 7 ). We reported a child less than 2 years old with postoperative pathological confirmed MA, who was considered as nephroblastoma by preoperative examination and received chemotherapy before surgical treatment.…”

Section: Introductionmentioning

confidence: 99%

Chemotherapy Combined With Surgery in a Case With Metanephric Adenoma

Hu¹,

Zhong²,

Wan³

et al. 2022

Front. Pediatr.

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BackgroundMetanephric adenoma is an extremely rare renal neoplasm, especially in pediatrics. Chemotherapy combined with surgery in metanephric adenoma has not been reported.MethodsWe describe a case of metanephric adenoma in a child less than 2 years old, which were treated by chemotherapy combined with surgery.ResultsNephron sparing surgery was performed after regular chemotherapy, and the pathological result was metanephric adenoma.ConclusionPediatric metanephric adenoma is extremely rare; the clinical manifestations and imaging examinations lack specificity. Nephron sparing surgery is recommended as the preferred treatment for metanephric adenoma. Long-term follow-up and more in-depth molecular genetic research are still needed to determine the benign or malignant of metanephric adenoma and whether chemotherapy drugs have an effect on it.

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