Paediatric nasal polyps in cystic fibrosis

Slim, Mohd Afiq Mohd; Dick, David; Trimble, Keith; McKee, Gary

doi:10.1136/bcr-2016-214467

Cited by 5 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To prevent early recurrence, simple polypectomy should be supplemented with uncinectomy, middle meatal antrostomy and anterior ethmoidectomy. Suspicion of CF should be raised when bilateral demineralized uncinate processes and medial displacement of the lateral nasal wall can be seen on CT of the paranasal sinuses or total opacification, hypoplastic frontal and sphenoid sinuses [ 17 , 18 ]. CT could predict the need for revision surgery because it can provide information about the extent of the disease, or the number of sinuses involved.…”

Section: Discussionmentioning

confidence: 99%

Nasal polyposis from cystic fibrosis in children – the experience of a single center

Iovănescu¹,

Pop²,

Vintila³

et al. 2023

Rom J Morphol Embryol

View full text Add to dashboard Cite

Background: Cystic fibrosis (CF) is the most common monogenic disease, characterized by clinically notable polymorphism. Respiratory disease is the main factor that influences the disease outcome and prognosis of the patient with CF, bacterial infections being responsible for severe exacerbations and rhinosinusitis a difficult complication, besides lung disease. Aim: The aim of the paper was to present a case series of CF-associated nasal polyposis and our management experience, providing new data for nasal and sinus complications. Patients, Materials and Methods: Patients attending the National Cystic Fibrosis Center, Timişoara, Romania, were evaluated for nasal polyposis. Besides clinical examination, endoscopy, and computed tomography (CT) was performed for comprehensive evaluation. Patients with persistent symptoms or with complicated sinusitis underwent surgical approach. Results: Fourteen (18.18%) children were diagnosed with nasal polyposis and had surgery, with positive outcomes. One patient received Omalizumab for an associated, uncontrolled asthma with a subsequent substantial effect with the significant polyp reduction and lack of recurrence. Conclusions: Even if extremely difficult to manage, complicated nasal polyposis CF related might have an improved outcome and better life quality.

show abstract

Section: Discussionmentioning

confidence: 99%

Nasal polyposis from cystic fibrosis in children – the experience of a single center

Iovănescu¹,

Pop²,

Vintila³

et al. 2023

Rom J Morphol Embryol

View full text Add to dashboard Cite

show abstract

“…Endoscopy revealed a nasal polyp (Video 1, supplementary materials) in the middle meatus, protruding in the right nasal fossa with mild nasal obstruction (endoscopic Type III nasal polyposis according to Stammberger Clinical classification) [7]. The NP diagnosis was histological proved.…”

Section: Casementioning

confidence: 97%

Nasal polyposis in pediatric patients with Cornelia de Lange syndrome: endoscopic diagnosis, treatment and follow up in two case reports

et al. 2023

View full text Add to dashboard Cite

Background Cornelia de Lange syndrome is a rare genetic disease with otolaryngological involvement. The classic phenotype is characterized by distinctive facial features, intellectual disability, growth delay, hirsutism, and upper-limb reduction. Nasal polyposis was previously reported in association with chronic rhinosinusitis, however data about prevalence, diagnosis, treatment and prognosis are lacking for this cohort of patients, affected by rare disease. Case presentation We describe the whole diagnostic and therapeutic workflow of nasal polyps in two pediatric patients with Cornelia de Lange, successfully diagnosed and treated by nasal endoscopy. Conclusion Our report confirm that nasal endoscopy is a safe and useful tool in the diagnosis, treatment and follow-up of nasal polyps, even in Cornelia de Lange syndrome pediatric patients. We want to increase the alert for the detection of nasal polyps in patients with Cornelia de Lange syndrome since pediatric age. We recommend endoscopy in all patients with Cornelia de Lange syndrome and symptoms of chronic nasal obstruction and/or OSAS. Multidisciplinary team and sedation service could be useful in the management of Cornelia de Lange syndrome patients with airway obstruction symptoms and sleep disturbance when severe intellectual disability, autism or psychiatric findings are present.

show abstract

Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management

Heath

Hartzell

Putt

et al. 2018

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

Chronic rhinosinusitis as a diagnosis is a conglomeration of multiple phenotypes and endotypes. As such, the diagnosis and management are complex. New survey studies provide some consensus on prevalence and management of this disease in children. In this review, we highlight the differential diagnosis of pediatric CRS, including non-eosinophilic/infectious variants, eosinophilic variants with and without nasal polyps, allergic fungal sinusitis, aspirin-exacerbated respiratory disease, primary immunodeficiency, and disorders of mucociliary clearance. Further, we detail treatment options that should be considered. Finally, we feature emerging potential treatment options of CRS, including anti-immunoglobulin E, interleukin-5, and interleukin-4 receptor alpha subunit.

show abstract

Paediatric nasal polyps in cystic fibrosis

Cited by 5 publications

References 32 publications

Nasal polyposis from cystic fibrosis in children – the experience of a single center

Nasal polyposis from cystic fibrosis in children – the experience of a single center

Nasal polyposis in pediatric patients with Cornelia de Lange syndrome: endoscopic diagnosis, treatment and follow up in two case reports

Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management

Contact Info

Product

Resources

About