Paediatric olfactory dysfunction: a chance to detect COVID-19?

Hall, Andrew; Frauenfelder, Claire; Butler, Colin R.; Coyle, Paula; Hopkins, Claire

doi:10.1136/archdischild-2020-319971

Cited by 7 publications

(6 citation statements)

References 3 publications

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“…4 Dermatological manifestations in children with mild disease are uncommon: acute infection has at times been associated with a maculopapular exanthem, but the pseudo chilblain lesions or "covid toes" seen in adults are rare. 5 6 Although assessing the prevalence of loss of taste or smell among children may be challenging (especially when children are unable to report these symptoms), 7 as with adults, some studies suggest the presence of loss of taste or smell may also be relatively specific for covid-19 among children. 8 Data that further disaggregate paediatric symptoms by age are relatively limited, but among infants the most common symptoms of acute covid-19 similarly include fever, cough, and nasal congestion.…”

Section: Presentation Of Sars-cov-2 Infection In Childrenmentioning

confidence: 99%

Acute covid-19 and multisystem inflammatory syndrome in children

Rubens

Akindele

Tschudy

et al. 2021

BMJ

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Section: Presentation Of Sars-cov-2 Infection In Childrenmentioning

confidence: 99%

Acute covid-19 and multisystem inflammatory syndrome in children

Rubens

Akindele

Tschudy

et al. 2021

BMJ

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“…All patients were checked with rapid antigen test due to the frequent influenza infection in order to exclude influenza, which is a common infection causing odor disorders in April [ 4 ]. Radiological evaluation were assessed at early phase of COVID-19 infection because to date no published pediatric anosmia screening tools in COVID-19 have been validated (Hall et al, 2020) [ 5 ]. We used cranial neuroimaging technique.…”

mentioning

confidence: 99%

Olfactory bulb magnetic resonance imaging in SARS-CoV-2-induced anosmia in pediatric cases

Hatipoğlu

Yazıcı

Palabıyık

et al. 2020

International Journal of Pediatric Otorhinolaryngology

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In this paper, we report three cases of pediatric patients with COVID-19 infection who presented with different symptoms and also anosmia and/or ageusia. The common feature of these 3 patients is that the smell and / or taste disorder developed without nasal symptoms such as nasal congestion, nasal obstruction or rhinorrhea. Although 40% of anosmies contains viral etiologies, COVID- 19 differs from other viral anosmies by the lack of nasal congestion and runny nose. Coronaviruses could invade the brain via the cribriform plate close to the olfactory bulb and the olfactory epithelium. We may expect some structural changes in the olfactory bulb so we evaluated our patient with cranial imaging.

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“…In addition, it has been reported that age, severity of the COVID-19 (mild to moderate or severe), and even ethnicity affects the clinical symptoms of COVID-19 [48][49][50]. We tried to evaluate the effect of these factors on the olfactory related symptoms.…”

Section: A C C E P T E D a R T I C L Ementioning

confidence: 99%

Predictive Value of Olfactory and Taste Symptoms in the Diagnosis of COVID-19: A Systematic Review and Meta-Analysis

Kim

Stybayeva

et al. 2021

Clin Exp Otorhinolaryngol

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Objectives: This study evaluated the diagnostic value of the various symptoms of COVID-19 in the screening of this disease.Methods: Two authors (working independently) comprehensively reviewed six databases (PubMed, Cochrane database, Embase, Web of Science, SCOPUS, and Google Scholar) from their dates of inception until November 2020. Patient-reported symptoms, including otolaryngologic and general symptoms, were evaluated for their predictive values in adults who underwent testing for COVID-19. True-positive, true-negative, false-positive, and false-negative data were extracted from each study. The methodological quality of included studies was evaluated using the Quality Assessment of Diagnostic Accuracy Studies tool (ver. 2). Results: Twenty-eight prospective and retrospective studies were included in the meta-analysis. The diagnostic odds ratio (DOR) of a change in olfaction and/or taste was 10.20 (95% confidence interval [CI], 8.43; 12.34). The area under the summary receiver operating characteristic curve was 0.8. Olfactory and/or taste changes had a low sensitivity (0.57, 95%CI: 0.47; 0.66) but moderate negative (0.78, 95%CI: 0.69; 0.85] and positive (0.78, 95%CI: 0.66; 0.87) predictive values and a high specificity (0.91, (95%CI: 0.83; 0.96). Olfactory and/or taste changes had a higher diagnostic value than the other otolaryngologic symptoms, a higher DOR and specificity, and a similar or higher diagnostic value than the other general symptoms. Conclusions: Among otolaryngologic symptoms, olfactory and/or taste dysfunction was the most highly associated with COVID-19 and its general symptoms and should be considered when screening for the disease.

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Paediatric olfactory dysfunction: a chance to detect COVID-19?

Cited by 7 publications

References 3 publications

Acute covid-19 and multisystem inflammatory syndrome in children

Acute covid-19 and multisystem inflammatory syndrome in children

Olfactory bulb magnetic resonance imaging in SARS-CoV-2-induced anosmia in pediatric cases

Predictive Value of Olfactory and Taste Symptoms in the Diagnosis of COVID-19: A Systematic Review and Meta-Analysis

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