Paeoniflorin ameliorates airway inflammation and immune response in ovalbumin induced asthmatic mice: From oxidative stress to autophagy

Han, Xin; Hu, Shaoqi; Qiao, Yi; Sang, Xianan; Tang, Dongdong; Cao, Gang

doi:10.1016/j.phymed.2021.153835

“…Chinese herbal medicines can also regulate autophagy and can be potentially used for asthma treatment. Paeoniflorin modulates mitochondrial function by suppressing autophagy and reducing the expression of pro-inflammatory factors to alleviate asthmatic inflammation ( 145 ). Astragalin can alleviate ROS-promoted bronchial fibrosis by inhibiting the formation of airway autophagosomes ( 142 ).…”

Section: Autophagy and Asthma Treatmentmentioning

confidence: 99%

New insights into autophagy in inflammatory subtypes of asthma

Dong

¹

,

Yang

²

,

Li

³

et al. 2023

Front. Immunol.

2

0

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Asthma is a heterogeneous airway disease characterized by airway inflammation and hyperresponsiveness. Autophagy is a self-degrading process that helps maintain cellular homeostasis. Dysregulation of autophagy is involved in the pathogenesis of many diseases. In the context of asthma, autophagy has been shown to be associated with inflammation, airway remodeling, and responsiveness to drug therapy. In-depth characterization of the role of autophagy in asthma can enhance the understanding of the pathogenesis, and provide a theoretical basis for the development of new biomarkers and targeted therapy for asthma. In this article, we focus on the relationship of autophagy and asthma, and discuss its implications for asthma pathogenesis and treatment.

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“…The main constituents ofP. lactiflora are glucosides, which have demonstrated anti-inflammatory, analgesic, antispasmodic, liver-protectant, and immunoregulating properties in previous studies [36][37][38][39][40] . Lin et al 41 reported that total glycosides ofP.…”

Section: Paeonia Lactifloramentioning

confidence: 99%

TGF-β Signaling: a Potential Therapeutic Target of Single Herbs and Extracts for Renal Fibrosis

gengzhen¹,

yaodan²,

chao³

et al. 2022

Preprint

0

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Chronic kidney disease has emerged as a global public health problem in recent years. Chronic kidney disease progression, characterized by the development of renal fibrosis, leads to end-stage kidney disease. Transforming growth factor β has been shown to play a key role in the mechanism of renal fibrosis. Several studies have shown that individual Chinese herbal extracts can inhibit transforming growth factor β activation and reduce extracellular matrix formation, thereby imparting an anti-renal fibrosis effect through multiple pathways and multiple targets. In the present manuscript, the research trends of single traditional Chinese medicines and extracts in preventing and treating renal fibrosis are summarized, which may be insightful for generating new ideas for preventing and delaying renal fibrosis.

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“…Paeonia lacti ora, a type of a paeony, is effective in calming the liver, relieving pain, nourishing blood for regulating menstruation, astringing Yin, and curing hidroschesis. The main constituents of P. lacti ora are glucosides, which have demonstrated anti-in ammatory, analgesic, antispasmodic, liver-protectant, and immunoregulating properties in previous studies [36][37][38][39][40] . Lin et al [41] reported that total glycosides of P. lacti ora downregulated NF-κB and toll-like receptor 4 (TLR4) expression in the kidneys of rats, inhibited the synthesis of TGF-β1, reduced the deposition of extracellular matrix, and delayed the progression of renal brosis.…”

Section: Paeonia Lacti Oramentioning

confidence: 99%

TGF-β Signaling: a Potential Therapeutic Target of Single Herbs and Extracts for Renal Fibrosis

Huang

¹

,

Liang

²

,

Ma

³

et al. 2022

Preprint

0

View full text Add to dashboard Cite

Chronic kidney disease has emerged as a global public health problem in recent years. Chronic kidney disease progression, characterized by the development of renal fibrosis, leads to end-stage kidney disease. Transforming growth factor β has been shown to play a key role in the mechanism of renal fibrosis. Several studies have shown that individual Chinese herbal extracts can inhibit transforming growth factor β activation and reduce extracellular matrix formation, thereby imparting an anti-renal fibrosis effect through multiple pathways and multiple targets. In the present manuscript, the research trends of single traditional Chinese medicines and extracts in preventing and treating renal fibrosis are summarized, which may be insightful for generating new ideas for preventing and delaying renal fibrosis.

show abstract

Paeoniflorin ameliorates airway inflammation and immune response in ovalbumin induced asthmatic mice: From oxidative stress to autophagy

Cited by 26 publications

References 58 publications

New insights into autophagy in inflammatory subtypes of asthma

New insights into autophagy in inflammatory subtypes of asthma

TGF-β Signaling: a Potential Therapeutic Target of Single Herbs and Extracts for Renal Fibrosis

TGF-β Signaling: a Potential Therapeutic Target of Single Herbs and Extracts for Renal Fibrosis

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