Paeoniflorin Enhances Endometrial Receptivity through Leukemia Inhibitory Factor

Park, Hye-Rin; Choi, Hong‐Seok; Kim, Bosung; Chung, Tae‐Wook; Kim, Keuk‐Jun; Joo, Jong Kil; Ryu, Dongryeol; Bae, Sung-Jin; Ha, Ki‐Tae

doi:10.3390/biom11030439

Cited by 15 publications

(10 citation statements)

References 64 publications

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“…Paeoniflorin (8 mg/kg b.w.) can enhance endometrial receptivity of luteal insufficiency (RU486-induced model) mice through the leukemia inhibitory factor [39]; Paeoniflorin (60 mg/kg b.w.) can also improve depression-like behavior in offspring of prenatally stressed mothers by restoring hypothalamic-pituitary-adrenal (H-P-A) axis and glucocorticoid receptor related dysfunction [40] Naringin Excessive naringin use in guinea pigs is lethal when naringin administration reaches 1250 mg/kg b.w.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy and Safety of the Zhuyun Formula and Auricular Acupressure for the Infertile Women with Recurrent Implantation Failure: A Randomized Controlled Trial

Zhou

Zheng

Xia

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Recurrent implantation failure (RIF), a clinical disorder characterized by failure to achieve pregnancy after repeated (≥3) embryo transfer, is a challenge for reproductive demands worldwide. In our preliminary work, the Zhuyun formula (ZYF) with auricular acupressure, a complementary and alternative medicine (CAM) with a small sample size for RIF, can improve the clinical pregnancy rate (41.2% vs. 26.7%, treatment group vs. control group, p < 0.05 ). Based on the toxicological and pregnancy-related pharmacological analysis of ZYF for RIF, the T-cell receptor signaling pathway might be involved in the pharmacological activity. This study aimed at evaluating the efficacy and safety of the CAM therapy according to pregnancy outcomes and maternal and child health and investigating the changes of T-helper (Th) cells in the peripheral blood of unexplained RIF women. Materials and Methods. We conducted a prospective, two-arms, randomized, nonblinded study. All eligible women were randomly assigned to the treatment group (TG) and the control group (CG) according to a computer-generated randomization list in sealed opaque envelopes. Blood samples were collected from the two groups, and serum Th1, Th2, and Treg were detected by flow cytometry. The cytokines were detected by an enzyme-linked immunosorbent assay (ELISA). The TG was administrated with ZYF and auricular acupressure for three months before ovarian stimulation, while the control group was on a waiting list for the same period. The primary outcome was CPR. The second outcomes were the serum levels of immune parameters. For the safety evaluation, the perinatal outcomes of maternal and child were obtained by follow-up. Post-hoc sensitivity analyses were performed to assess the effect of missing data. Results. One hundred and twenty-three women were randomized into the TG (n = 62) and CG (n = 61). The CPR was increased significantly in the TG (45.2%) than CG (26.2%) (p = 0.029). Twenty blood samples were collected, and the Th2/Th1 and Treg expression level was significantly higher in the TG than in the CG. IL-2, IL-10, and Foxp3 were higher significantly in the TG than in the CG. The maternal and child perinatal outcomes were not significantly different between the two groups. Conclusions. The ZYF with auricular acupressure was effective and safe in improving the pregnancy outcomes of RIF. It might be related to balancing the level of cytokines related to the immune tolerance of the maternal-fetal interface to protect the embryo from the maternal immune system. Clinical Trial Registration: Clinical Trial Registry; date: 14/Dec/2013; no. NCT03078205.

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Section: Discussionmentioning

confidence: 99%

The Efficacy and Safety of the Zhuyun Formula and Auricular Acupressure for the Infertile Women with Recurrent Implantation Failure: A Randomized Controlled Trial

Zhou

Zheng

Xia

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Among these autophagy inducers derived from natural products, 10 compounds, berberine, brefeldin A, curcumin, chrysin, fisetin, α-mangostin, paeoniflorin, rapamycin, γ-tocotrienol, and ursolic acid, have been reported to enhance the female fertility rate by reducing polycystic ovary syndrome (PCOS) and ovarian cell death, protecting the ovary from damage, and improving embryo quality and ovarian life span [103][104][105][106][107][108][109][110][111][112][113][114][115][116][117]. Several of the 10 natural compounds that improve fertility, including berberine, paeoniflorin, ursolic acid, and deferoxamine, have been reported to ameliorate endometriosis [103,[118][119][120][121]. Endometriosis is a major cause of female infertility and is associated with reduced oocyte quality and implantation failure [122,123].…”

Section: Potential Involvement Of Autophagic Regulation On the Effect Of Natural Products As Embryo Implantation Enhancermentioning

confidence: 99%

“…Four compounds, apigenin, curcumin, genistein, and quercetin, were identified as antagonists for embryo implantation [124][125][126][127][128][129][130]. Four compounds, berberine, emodin, paeoniflorin, and γ-tocotrienol, increased implantation rates by increasing endometrial receptivity or decidualization [103,116,120,131,132]. In contrast, resveratrol has been shown to have dual effects as an agonist and antagonist [133,134].…”

Section: Potential Involvement Of Autophagic Regulation On the Effect Of Natural Products As Embryo Implantation Enhancermentioning

confidence: 99%

“…improved endometrial receptivity [225]. Paeoniflorin is the main active ingredient of P. lactiflora for increasing endometrial receptivity via LIF expression [120]. In addition, paeoniflorin has been reported to induce autophagy and AMPK activation in several types of cells [114,230,231].…”

Section: Possible Role Of Autophagy On the Effect Of Medicinal Herbal Drugs As Embryo Implantation Enhancermentioning

confidence: 99%

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Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

Park

Cho

et al. 2021

Pharmaceuticals

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Infertility is an emerging health issue worldwide, and female infertility is intimately associated with embryo implantation failure. Embryo implantation is an essential process during the initiation of prenatal development. Recent studies have strongly suggested that autophagy in the endometrium is the most important factor for successful embryo implantation. In addition, several studies have reported the effects of various natural products on infertility improvement via the regulation of embryo implantation, embryo quality, and endometrial receptivity. However, it is unclear whether natural products can improve embryo implantation ability by regulating endometrial autophagy. Therefore, we performed a literature review of studies on endometrial autophagy, embryo implantation, natural products, and female infertility. Based on the information from these studies, this review suggests a new treatment strategy for female infertility by proposing natural products that have been proven to be safe and effective as endometrial autophagy regulators; additionally, we provide a comprehensive understanding of the relationship between the regulation of endometrial autophagy by natural products and female infertility, with an emphasis on embryo implantation.

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“…Paeonia lactiflora Pall. is a traditional Chinese herbal medicine belonging to the Ranunculaceae family, which possesses the ability to reduce pain, relieve abdominal cramps, and improve blood circulation [ 9 , 10 ]. Oxypaeoniflorin (Oxy) and paeoniflorin are two major active components in Paeonia lactiflora , both of which could exert anti-inflammatory and antiapoptotic effects [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Oxypaeoniflorin Prevents Acute Lung Injury Induced by Lipopolysaccharide through the PTEN/AKT Pathway in a Sirt1‐Dependent Manner

Fan

Tong

Wang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Acute lung injury (ALI) is featured by pulmonary edema, alveolar barrier injury, inflammatory response, and oxidative stress. The activation of Sirt1 could relieve lipopolysaccharide- (LPS-) induced murine ALI by maintaining pulmonary epithelial barrier function. Oxypaeoniflorin (Oxy) serves as a major component of Paeonia lactiflora Pall., exerting cardioprotection by activating Sirt1. However, the role of Oxy in ALI induced by LPS remains unclear. The aim of the present study is to illustrate the modulatory effects and molecular mechanisms by which Oxy operates in ALI induced by LPS. The intraperitoneal injection of LPS was performed to establish the murine ALI model while LPS-treated alveolar epithelial cells were used to mimic the in vitro ALI model. Levels of lung injury, oxidative stress, and inflammatory response were detected to observe the potential effects of Oxy on ALI. Oxy treatment mitigated lung edema, inflammatory response, and oxidative stress in mouse response to LPS, apart from improving 7-day survival. Meanwhile, Oxy also increased the expression and activity of Sirt1. Intriguingly, Sirt1 deficiency or inhibition counteracted the protective effects of Oxy treatment in LPS-treated mice or LPS-treated alveolar epithelial cells by regulating the PTEN/AKT signaling pathway. These results demonstrated that Oxy could combat ALI in vivo and in vitro through inhibiting inflammatory response and oxidative stress in a Sirt1-dependent manner. Oxy owns the potential to be a promising candidate against ALI.

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Paeoniflorin Enhances Endometrial Receptivity through Leukemia Inhibitory Factor

Cited by 15 publications

References 64 publications

The Efficacy and Safety of the Zhuyun Formula and Auricular Acupressure for the Infertile Women with Recurrent Implantation Failure: A Randomized Controlled Trial

The Efficacy and Safety of the Zhuyun Formula and Auricular Acupressure for the Infertile Women with Recurrent Implantation Failure: A Randomized Controlled Trial

Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

Oxypaeoniflorin Prevents Acute Lung Injury Induced by Lipopolysaccharide through the PTEN/AKT Pathway in a Sirt1‐Dependent Manner

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