Paeoniflorin inhibits cell viability and invasion of liver cancer cells via inhibition of Skp2

Liu, Hong; Zang, Lili; Zhao, Jun; Wang, Zhaolin; Li, Lingyun

doi:10.3892/ol.2020.11424

Cited by 8 publications

(6 citation statements)

References 38 publications

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“…In consistent with the previous report [14,15], CP-25 significantly suppressed cell proliferation, induces cell apoptosis, and enhances the efficacy of 5-Fu in HCC in vivo and in vitro. These results indicated that combination administration of CP-25 and 5-Fu in certain degree may be a potent therapeutic regimen to treat HCC.…”

Section: Discussionsupporting

confidence: 92%

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Synergistic effects of CP-25 and 5-fluorouracil on the hepatocellular carcinoma in vivo and in vitro through regulating activating mitochondrial pathway

Chang¹,

Jiang²,

Jin³

et al. 2022

J. Cancer

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Paeoniflorin-6'-O-benzene sulfonate (CP-25) has therapeutic potential for the treatment of hepatocellular carcinoma (HCC). 5-Fluorouracil (5-Fu) has been a conventional chemotherapeutic agent for HCC. Unfortunately, the nonspecific cytotoxicity and multidrug resistance caused by long-term use limited the clinical efficacy of 5-Fu. This study was aimed to investigate whether the combination of CP-25 and 5-Fu could generate synergistic effect in inhibiting HCC. The experiments on the diethylnitrosamine (DEN) -induced mice showed that compared with applying single drugs, the combination of CP-25 and 5-Fu presented stronger inhibition in tumor nodule and volume. Meanwhile, CP-25 and 5-Fu activated the intrinsic mitochondrial apoptosis pathway induced by P53, inhibited anti-apoptotic B-cell lymphoma (Bcl-2), induced the pro-apoptotic Bcl-2-associated X protein (Bax), Cytochrome-C and caspases. In addition, the synergistic effect was also validated in Bel-7402 and HepG-2 cells in vitro. This research not only provides a novel and effective combination strategy for the therapy of HCC but also provides an experimental basis for the development of CP-25 and 5-Fu compound preparation.

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Section: Discussionsupporting

confidence: 92%

“…International Publisher used as an herbal medicine to treat arthritis, systemic lupus erythematosus (SLE), fibrosis, hepatic granuloma, diabetic nephropathy (DN) and cancer [10][11][12][13][14][15]. Meanwhile, the anti-inflammatory and immunoregulatory effects of CP-25 have been verified in many studies [16][17][18].…”

Section: Ivyspringmentioning

confidence: 99%

Synergistic effects of CP-25 and 5-fluorouracil on the hepatocellular carcinoma in vivo and in vitro through regulating activating mitochondrial pathway

Chang¹,

Jiang²,

Jin³

et al. 2022

J. Cancer

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“…Paeoniflorin is a monoterpene glycoside with various anti-cancer activities and is derived from Paeonia lactiflora . Studies have shown that paeoniflorin has broad-spectrum anti-tumor activities against various cancers ( 76 ), including those of liver ( 77 ), lungs ( 78 ), breast ( 79 ), and pancreas ( 80 ). miR-124 levels are significantly increased in paeoniflorin-treated MGC-803 cells, which inhibits PI3K/Akt and p-STAT3 expression.…”

Section: Active Ingredients Of Chinese Medicine Targeting Mirna Inhibmentioning

confidence: 99%

Anti-Tumor Mechanisms Associated With Regulation of Non-Coding RNA by Active Ingredients of Chinese Medicine: A Review

Liu

Qiu

et al. 2021

Front. Oncol.

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Cancer has become the second leading cause of death worldwide; however, its complex pathogenesis remains largely unclear. Previous research has shown that cancer development and progression are closely associated with various non-coding RNAs, including long non-coding RNAs and microRNAs, which regulate gene expression. Target gene abnormalities are regulated and engaged in the complex mechanism underlying tumor formation, thereby controlling apoptosis, invasion, and migration of tumor cells and providing potentially effective targets for the treatment of malignant tumors. Chemotherapy is a commonly used therapeutic strategy for cancer; however, its effectiveness is limited by general toxicity and tumor cell drug resistance. Therefore, increasing attention has been paid to developing new cancer treatment modalities using traditional Chinese medicines, which exert regulatory effects on multiple components, targets, and pathways. Several active ingredients in Chinese medicine, including ginsenoside, baicalin, and matrine have been found to regulate ncRNA expression levels, thus, exerting anti-tumor effects. This review summarizes the scientific progress made regarding the anti-tumor mechanisms elicited by various active ingredients of Chinese medicine in regulating non-coding RNAs, to provide a theoretical foundation for treating tumors using traditional Chinese medicine.

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“…or Paeonia veitchii Lynch, which have been used to treat various liver diseases in the traditional medicine of China for many years [ 17 ]. Moreover, it has been verified, in recent research, that PF can protect the liver, prevent non-alcoholic fatty liver disease, relieve liver fibrosis, and inhibit hepatocellular carcinoma through the activities of anti-inflammatory, anti-oxidative stress, and anti-apoptosis [ 18 , 19 ]. Our studies also proved that PF demonstrates the significant effect of cholestasis alleviation via multiple pathways [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Paeoniflorin Protects against Acetaminophen-Induced Liver Injury in Mice via JNK Signaling Pathway

Deng

et al. 2022

Molecules

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Background: Drug-induced liver injury (DILI), represented by acetaminophen (APAP), is a common cause of acute liver failure in clinics. Paeoniflorin (PF) has been proven to demonstrate a significant hepatoprotective effect. However, it is still unclear whether it can be a potential agent against hepatotoxicity induced by APAP. This study aimed to explore the preventive and therapeutic effects and mechanisms of PF on APAP-induced liver injury. Methods: Different doses of PF (50, 100, and 200 mg/kg) were given to C57BL/6 male mice for five consecutive days. After 12 h of APAP (250 mg/kg i.p.) treatment, blood and liver tissues were collected and isolated for detection. Results: The results showed that the therapeutic effects of PF on APAP mice were presented in the downregulation of the content of serum indices and significantly improved hepatic tissue edema and inflammatory infiltration. Meanwhile, PF reduces the level of the mitochondrial metabolic enzyme. Ulteriorly, it was found that PF has a downregulating effect on the apoptotic reaction and could inhibit the protein expression of CYP2E1/JNK signaling, which in turn reduces the damage of APAP. Conclusion: Our findings showed that PF acted as a protective agent against APAP-induced hepatotoxicity by inhibiting JNK-related signals, suggesting a novel insight into treating APAP-induced liver injury.

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Paeoniflorin inhibits cell viability and invasion of liver cancer cells via inhibition of Skp2

Cited by 8 publications

References 38 publications

Synergistic effects of CP-25 and 5-fluorouracil on the hepatocellular carcinoma in vivo and in vitro through regulating activating mitochondrial pathway

Synergistic effects of CP-25 and 5-fluorouracil on the hepatocellular carcinoma in vivo and in vitro through regulating activating mitochondrial pathway

Anti-Tumor Mechanisms Associated With Regulation of Non-Coding RNA by Active Ingredients of Chinese Medicine: A Review

Paeoniflorin Protects against Acetaminophen-Induced Liver Injury in Mice via JNK Signaling Pathway

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