Paeonol inhibits NLRP3 mediated inflammation in rat endothelial cells by elevating hyperlipidemic rats plasma exosomal miRNA-223

Shi, Xiaoyan; Xie, Xianmei; Sun, Ying; He, Hai; Huang, Hanwen; Liu, Yarong; Wu, Hongfei; Dai, Min

doi:10.1016/j.ejphar.2020.173473

Cited by 46 publications

(37 citation statements)

References 46 publications

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“…211 Paeonol, a potential therapeutic agent for atherosclerosis, inhibits inflammatory cytokines (IL-1β and IL-6) and NLRP3 inflammasome activation through the upregulation of miR-223 in rat aortic endothelial cells (RAECs). 212 Recent studies have also shown that other miRNAs in addition to miR-223-3p are involved in the negative regulation of the NLRP3 inflammasome. For example, miR-139 targeting c-Jun inhibits nerve injury induced by oxygen-glucose deprivation/ reoxygenation (OGD/R) through the inhibition of NLRP3 inflammasome activation and cell pyroptosis.…”

Section: Dual Regulatory Mechanisms Controlling the Nlrp3 Inflammasomementioning

confidence: 99%

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An update on the regulatory mechanisms of NLRP3 inflammasome activation

et al. 2021

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The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is a multiprotein complex involved in the release of mature interleukin-1β and triggering of pyroptosis, which is of paramount importance in a variety of physiological and pathological conditions. Over the past decade, considerable advances have been made in elucidating the molecular mechanisms underlying the priming/licensing (Signal 1) and assembly (Signal 2) involved in NLRP3 inflammasome activation. Recently, a number of studies have indicated that the priming/licensing step is regulated by complicated mechanisms at both the transcriptional and posttranslational levels. In this review, we discuss the current understanding of the mechanistic details of NLRP3 inflammasome activation with a particular emphasis on protein-protein interactions, posttranslational modifications, and spatiotemporal regulation of the NLRP3 inflammasome machinery. We also present a detailed summary of multiple positive and/or negative regulatory pathways providing upstream signals that culminate in NLRP3 inflammasome complex assembly. A better understanding of the molecular mechanisms underlying NLRP3 inflammasome activation will provide opportunities for the development of methods for the prevention and treatment of NLRP3 inflammasome-related diseases.

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Section: Dual Regulatory Mechanisms Controlling the Nlrp3 Inflammasomementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An update on the regulatory mechanisms of NLRP3 inflammasome activation

et al. 2021

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“…Moreover, paeonol decreased the expression of NLRP3, caspase-1, and ICAM-1. These results showed that paeonol inhibited the downstream NLRP3 inflammasome pathway by increasing the level of miRNA-223 in plasma-derived exosomes of hyperlipidemic rats ( 121 ). Yuan et al explored the effects of paeonol on miRNA-126 expression and its ability to inhibit monocyte adhesion to ox-LDL-injured VECs.…”

Section: Pharmacological Mechanisms Of Paeonol On Atherosclerotic Cardiovascular Diseasementioning

confidence: 95%

Paeonol for the Treatment of Atherosclerotic Cardiovascular Disease: A Pharmacological and Mechanistic Overview

et al. 2021

Front. Cardiovasc. Med.

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With improvement in living standards and average life expectancy, atherosclerotic cardiovascular disease incidences and mortality have been increasing annually. Paeonia suffruticosa, a natural herb, has been used for the treatment of atherosclerotic cardiovascular disease for thousands of years in Eastern countries. Paeonol is an active ingredient extracted from Paeonia suffruticosa. Previous studies have extensively explored the clinical benefits of paeonol. However, comprehensive reviews on the cardiovascular protective effects of paeonol have not been conducted. The current review summarizes studies reporting on the protective effects of paeonol on the cardiovascular system. This study includes studies published in the last 10 years. The biological characteristics of Paeonia suffruticosa, pharmacological mechanisms of paeonol, and its toxicological and pharmacokinetic characteristics were explored. The findings of this study show that paeonol confers protection against atherosclerotic cardiovascular disease through various mechanisms, including inflammation, platelet aggregation, lipid metabolism, mitochondria damage, endoplasmic reticulum stress, autophagy, and non-coding RNA. Further studies should be conducted to elucidate the cardiovascular benefits of paeonol.

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“…It could increase monocyte exosome-derived miR-223 [57]. Additionally, Pae could increase the miR-223 expression level in exosomes derived from the plasma of hyperlipidemic rats to inhibit the NLRP3 inflammasome pathway in endothelial cells, supporting its therapeutic potentials in AS [37,57]. In an endothelial cell study in pigs, miR-223 targeting NLRP3 alleviated inflammation development in porcine endothelial cells and triggered the aorta inflammatory injury [58].…”

Section: Role Of Mir-223 In Endothelial Inflammationmentioning

confidence: 96%

“…However, retinoic acid triggers C/EBPα to bind to the miR-223 promoter competitively and up-regulates miR-223 expression, inhibiting NFIA expression in a targeted manner and promotes granulocyte differentiation (Figure 2) [11,14]. Attenuates endothelial cell injury [18,37,38] Epithelial cells NLRP3, Sirt1, and ST1M1…”

Section: Role Of Mir-223 In Granulocyte Differentiationmentioning

confidence: 99%

miR-223: An Effective Regulator of Immune Cell Differentiation and Inflammation

Jiao¹,

Wang²,

Luoreng³

et al. 2021

Int. J. Biol. Sci.

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MicroRNAs (miRNAs) play a critical role in regulating various biological processes, such as cell differentiation and immune modulation by binding to their target genes. miR-223 is a miRNA with important functions and has been widely investigated in recent years. Under certain physiological conditions, miR-223 is regulated by different transcription factors, including sirtuin1 (Sirt1), PU.1 and Mef2c, and its biological functions are mediated through changes in its cellular or tissue expression. This review paper summarizes miR-223 biosynthesis and its regulatory role in the differentiation of granulocytes, dendritic cells (DCs) and lymphocytes, macrophage polarization, and endothelial and epithelial inflammation. In addition, it describes the molecular mechanisms of miR-223 in regulating lung inflammation, rheumatoid arthritis, enteritis, neuroinflammation and mastitis to provide insights into the existing molecular regulatory networks and therapies for inflammatory diseases in humans and animals.

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Paeonol inhibits NLRP3 mediated inflammation in rat endothelial cells by elevating hyperlipidemic rats plasma exosomal miRNA-223

Cited by 46 publications

References 46 publications

An update on the regulatory mechanisms of NLRP3 inflammasome activation

An update on the regulatory mechanisms of NLRP3 inflammasome activation

Paeonol for the Treatment of Atherosclerotic Cardiovascular Disease: A Pharmacological and Mechanistic Overview

miR-223: An Effective Regulator of Immune Cell Differentiation and Inflammation

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