Paget’s Disease of the Nipple

Ascensão, A.C.; Marques, Manuel Sacramento; Capitão-Mor, Manuela

doi:10.1159/000249526

Cited by 41 publications

(5 citation statements)

References 3 publications

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“…59 MPD can occur at any age but is more common in older patients. 60 It can arise in the setting of ipsilateral invasive carcinoma or DCIS or occur in the absence of either. Of 1704 women with MPD registered in the 1988-2002 SEER database, 50.4% had ipsilateral invasive carcinoma, 36.3% had ipsilateral DCIS, and 13.3% had MPD alone.…”

Section: Paget Disease Of the Breast Clinical Featuresmentioning

confidence: 99%

“…Analysis of 1973–2002 SEER data showed that the age-adjusted incidence rate of MPD in selected states in the United States peaked in 1985 (1.5 per 100,000-woman years) and has decreased yearly thereafter, with a 45% decrease between 1988 and 2002, likely secondary to the implementation of breast cancer screening 59 . MPD can occur at any age but is more common in older patients 60 . It can arise in the setting of ipsilateral invasive carcinoma or DCIS or occur in the absence of either.…”

Section: Paget Disease Of the Breastmentioning

confidence: 99%

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Nipple Lesions of the Breast

Brogi,

Scatena

2023

Advances in Anatomic Pathology

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Because of the unique anatomic structure of the nipple, a few specific breast lesions occur only at this site. Large lactiferous sinuses may be involved by inflammatory conditions such as squamous metaplasia of lactiferous ducts and ductal ectasia or be the site of uncommon superficial epithelial neoplasms such as nipple adenoma or syringomatous tumor of the nipple. Paget disease of the nipple may be secondary to intraepidermal extension of ductal carcinoma in situ in the underlying lactiferous ducts or develop from malignant transformation of Toker cells. Invasive breast cancer may also arise primarily in the nipple. Most of these conditions present as a palpable mass and/or skin changes with or without nipple discharge. Due to the delicate location and often relatively small size of nipple lesions, biopsy specimens are often superficial and fragmented, and the interpretation is challenging. Knowledge of the morphologic and immunophenotypic features of nipple lesions is essential in making the correct diagnosis. Information on the molecular alterations underpinning nipple neoplasms is currently very limited.

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Section: Paget Disease Of the Breast Clinical Featuresmentioning

confidence: 99%

Section: Paget Disease Of the Breastmentioning

confidence: 99%

Nipple Lesions of the Breast

Brogi,

Scatena

2023

Advances in Anatomic Pathology

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“…Multiple research studies validate that approximately 50% of patients diagnosed with MPD exhibit a detectable breast mass, and 90-94% are linked to underlying invasive disease. Conversely, instances involving a lesion that lacks a discernible mass typically correlate with DCIS [1,37,39,40]. Some patients may not exhibit suggestive signs of MPD with an occasional PC finding through histopathologic NAC examination during mastectomy.…”

Section: Diagnosismentioning

confidence: 99%

A Pictorial Exploration of Mammary Paget Disease: Insights and Perspectives

Mariano,

Nicosia,

Pupo

et al. 2023

Cancers

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Mammary Paget disease (MPD) is a rare condition primarily affecting adult women, characterized by unilateral skin changes in the nipple–areolar complex (NAC) and frequently associated with underlying breast carcinoma. Histologically, MPD is identified by large intraepidermal epithelial cells (Paget cells) with distinct characteristics. Immunohistochemical profiles aid in distinguishing MPD from other skin conditions. Clinical evaluation and imaging techniques, including magnetic resonance imaging (MRI), are recommended if MPD is suspected, although definitive diagnosis always requires histological examination. This review delves into the historical context, epidemiology, pathogenesis, clinical manifestations, and diagnosis of MPD, emphasizing the need for early detection. The classification of MPD based on pathogenesis is explored, shedding light on its varied presentations. Treatment options, including mastectomy and breast-conserving surgery, are discussed with clear guidelines for different scenarios. Adjuvant therapies are considered, particularly in cases with underlying breast cancer. Prognostic factors are outlined, underlining the importance of early intervention. Looking to the future, emerging techniques, like liquid biopsy, new immunohistochemical and molecular markers, and artificial intelligence-based image analysis, hold the potential to transform MPD diagnosis and treatment. These innovations offer hope for early detection and improved patient care, though validation through large-scale clinical trials is needed.

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“…It is common in postmenopausal women from the 5 th decade and above. Some cases have been reported in adolescents [38] .…”

Section: Types Of Premalignant and Malignant Cancers Of The Breastmentioning

confidence: 99%

Types of precancerous and cancerous breast lesions at pathology laboratory of the Buea Regional Hospital-Cameroon

Andrew,

Greenspan,

Akintunde

et al. 2022

Int. J. Oncol. Res.

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Introduction: Breast cancer is the 1 st gynaecological cancer globally, with 2.100.000 cases, among which 627.000 are fatal annually. These figures are projected to get to 14.000.000 cases and 8.200.000 deaths in the next two decades. Breast cancer is a variety of different histological types of cancers. The types of cancers are ductal carcinoma in situ, lobular carcinoma in situ, invasive breast cancer, inflammatory carcinoma, papilloma, medullary carcinoma, phyllode tumours, and Paget disease. Methodology: A descriptive retrospective study was carried out based on the registry of the pathology laboratory of the Buea regional hospital, Cameroon. The period was from the 04th of March 2016 to the 25th of May 2019. Results: In terms of frequency, the following types of precancerous lesions and cancers were recorded: invasive breast carcinoma, carcinoma in situ, papilloma, inflammatory carcinoma, phyllode tumours and angiosarcoma. Their respective percentages were; 74.84, 14, 47, 6.92, 1.89, 1.57, and 0.32 Conclusion: Breast cancer is a heterogeneous malignancy made of various histological types. Our study identified the following pathologies in order of frequency: invasive breast carcinoma, ductal carcinoma in situ, papilloma, inflammatory carcinoma, phylloid tumours and angiosarcoma. Objective: the objective of the study was to find out the frequency of various types of breast cancer and precancerous lesions.

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Paget’s Disease of the Nipple

Cited by 41 publications

References 3 publications

Nipple Lesions of the Breast

Nipple Lesions of the Breast

A Pictorial Exploration of Mammary Paget Disease: Insights and Perspectives

Types of precancerous and cancerous breast lesions at pathology laboratory of the Buea Regional Hospital-Cameroon

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