Pain and Analgesia Evaluated by the Intraperitoneal Bradykinin-Evoked Pain Method in Man

Lim, R. K. S.; Miller, David; Guzman, F.; Rodgers, D. W.; Rogers, R. W.; Wang, S. K.; Chao, Pei-Chieh; Shih, Tiffany Ting-Fang

doi:10.1097/00132586-196810000-00036

Cited by 14 publications

(21 citation statements)

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“…Similarly, i.p. administration of bradykinin to human subjects (Lim et al 1967) failed to evoke pain in all subjects. Further, because animals are typically sacrificed at the end of the experiment, withinanimal reproducibility cannot be tested.…”

Section: Writhing Testmentioning

confidence: 88%

Visceral Pain

Schwartz¹,

Gebhart²

2014

Current Topics in Behavioral Neurosciences

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Modeling visceral pain requires an appreciation of the underlying neurobiology of visceral sensation, including characteristics of visceral pain that distinguish it from pain arising from other tissues, the unique sensory innervation of visceral organs, the functional basis of visceral pain, and the concept of viscero-somatic and viscero-visceral convergence. Further, stimuli that are noxious when applied to the viscera are different than stimuli noxious to skin, muscle, and joints, thus informing model development and assessment. Visceral pain remains an important and understudied area of pain research and basic science knowledge and mechanisms acquired using animal models can translate into approaches that can be applied to the study and development of future therapeutics.

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Section: Writhing Testmentioning

confidence: 88%

Visceral Pain

Schwartz¹,

Gebhart²

2014

Current Topics in Behavioral Neurosciences

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“…Sympathomimetic drugs, such as amphetamine and ephedrine, are also positive in the acetylcholine test. Some authors, however, believe that sympathomimetic drugs do have an analgesic effect in man (Ivy, Goetzl, Harris & Burrill, 1944;Harris & Worley, 1957 ;Benassi & Munarini, 1958 ;Randall, 1963 ;Lim, Miller, Guzman, Rodgers, Rogers, Wang, Chao & Shih, 1967 Kast & Collins (1964); Keats & Telford (1956); Lasagna (1964) ;Lasagna, De Kornfeld & Pearson (1964); Light & Fink (1965);and Pearson & Lasagna (personal communication). Parenteral treatment in man refers to the subcutaneous or intramuscular route.…”

Section: Discussionmentioning

confidence: 99%

The Abdominal Constriction Response and Its Suppression by Analgesic Drugs in the Mouse

Collier¹,

Dinneen²,

Johnson³

et al. 1968

British Journal of Pharmacology and Chemotherapy

1,044

749

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“…In man, the intra-arterial (Burch & De Pasquale, 1962;Guzman, Braun & Lim, 1962;Sicuteri, Franchi & Fanciullacci, 1964) and intraperitoneal (Lim, Miller, Guzman, Rodgers, Rodgers, Wang, Chao & Shih, 1967) injection of bradykinin is followed by a painful sensation.…”

mentioning

confidence: 99%

Modifications of dorsal horn cell activities in the spinal cord, after intra‐arterial injection of bradykinin

Besson¹,

Conseiller²,

Hamann³

et al. 1972

The Journal of Physiology

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SUMMARY1. A method is described to study the modification in the activity of the lamina IV and V cells of the dorsal horn under the intra-arterial administration of bradykinin into the hind limb of the spinal cat.2. The modifications induced by intra-arterial injection of bradykinin preferentially affected the lamina V cells (77 % of the units) and produced few changes in the lamina IV cells (16 % of the units showed variations). 3. 52 % of the lamina V cells were activated; the mean increase in the firing rate was 700 %. The mean latency of the effect was 20 sec and the mean duration was 47 sec. However, there was large variance in the excitatory effect across cells. On the other hand, for the same cell, the observed effects were perfectly reproducible and injections of physiological fluid induced no response.4. 25 % of the lamina V cells were inhibited. Generally, the activity of the cell was reduced to 13 % of its initial value; in some cases, a total suppression of activity was observed. The mean latency of the inhibitory effect was 12 sec and its duration 28 sec. All these units had a very wide inhibitory field (activated by stimulations of low intensity) which asymmetrically surrounds the excitatory field.5. This study confirms the role played by the lamina V cells in the transmission of nociceptive messages. The existence of inhibitory phenomena is in favour of the gate control theory described by Melzack & Wall (1965) without deciding the pre-or post-synaptic nature of these mechanisms.

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Pain and Analgesia Evaluated by the Intraperitoneal Bradykinin-Evoked Pain Method in Man

Cited by 14 publications

References 0 publications

Visceral Pain

Visceral Pain

The Abdominal Constriction Response and Its Suppression by Analgesic Drugs in the Mouse

Modifications of dorsal horn cell activities in the spinal cord, after intra‐arterial injection of bradykinin

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