Pain intensity and salivary α‐amylase activity in patients following mandibular third molar surgery

Surin, Wanvipa; Chatiketu, Piyanart; Hutachok, Nuntouchaporn; Srichairatanakool, Somdet

doi:10.1002/cre2.628

Cited by 8 publications

(1 citation statement)

References 40 publications

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“…[ 10 ] A positive correlation has been shown in studies between salivary a-amylase and pain level in patients who were posted for surgery before and after. [ 11 , 12 ] Studies have shown that secretory IgA (sIgA) levels may interfere with the pain experienced by the patient and it may have a negative correlation with pain. [ 13 ] Both soluble tumour necrosis factor-α receptor II (sTNF-RII) and sIgA can be a reliable salivary biomarkers for pain assessment but sTNF-RII can be more accurate in diagnosing pain in people with advanced dementia.…”

Section: Discussionmentioning

confidence: 99%

Non-Invasive Objective Markers to Measure Pain: A Direction to Develop a Pain Device - A Narrative Review

Shekhar

Choudhary

Rathore

et al. 2023

IJPC

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Objective: To review the literature regarding non-invasive objective measurements of pain. Measuring pain is of uttermost importance, but it can be an inconvenient task, especially in terms of the interpretation of patient’s information. Reiterating, there is no “standard” that provides the physician with a method to objectively quantify this problem of patient’s pain. For assessing the pain, physician relies solely on unidimensional assessment tools or questionnaire-based pain assessment. Although pain is a subjective experience of the patient, but there is a need to measure pain sometimes in the individuals who cannot communicate their quality and severity of pain. Material and Methods: The articles from PubMed and Google Scholar without any year and age limit were searched in the current narrative review. A total of 16 markers were searched and their relation to pain was studied. Results: Studies have shown that these markers change in relation to pain and it can be considered a valuable tool for pain measurement but there are multiple factors like psychological and emotional factors which affect these markers. Conclusion: There is lack of evidence to show which marker can be used for measuring pain accurately. This narrative review is an attempt to look into the various pain-related markers that can be used and it calls for further studies including clinical trials with different diseases and taking into accounts different factors affecting pain to give an accurate measurement of pain.

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Section: Discussionmentioning

confidence: 99%

Non-Invasive Objective Markers to Measure Pain: A Direction to Develop a Pain Device - A Narrative Review

Shekhar

Choudhary

Rathore

et al. 2023

IJPC

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Pain intensity and salivary α‐amylase activity in patients following mandibular third molar surgery

Surin

Chatiketu

Hutachok

et al. 2022

Clinical & Exp Dental Res

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Objective: We aimed to compare the levels of pain and salivary α-amylase (SAA) in patients before and after mandibular third molar surgery.Materials and Methods: Patients were divided into asymptomatic and symptomatic groups and were then identified by the analgesic drug taken throughout the 2-week study. The visual analog scale (VAS) was employed to evaluate the severity of pain experienced by a given subject before treatment, when the anesthetic wore off, in the morning, and at night for a period of 1 week. Saliva was collected from the mouth floor of the subjects and the levels of SAA activity were measured at indicated times. Results:The levels of postoperative pain were higher than those of pretreatment pain (p < 0.05), but were not necessarily different between the two groups. The pain levels were positively correlated with SAA activities in both groups (p < 0.05). There was no difference between the number of analgesics taken by the two groups and the postoperative complications observed during the study. A significant correlation was observed between the VAS pain scale and SAA activities. Conclusion:SAA would be a simple effective biomarker for the objective assessment of pain intensity in patients who have undergone mandibular third molar surgery.

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A New Strategy for Measuring Salivary Alpha‐Amylase Activity Using Glucometer

Abdi,

Gorgani‐Firuzjaee,

Behroozi

et al. 2024

Starch Stärke

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Alpha‐amylase is one of the most important enzymes in the saliva. It is an important biomarker for many health conditions. Saliva sampling is a non‐invasive method and is the preferred choice for sampling at point of the care and home testing. Measurement of salivary alpha‐amylase activity as a rapid test using test strips with Flavin‐dependent glucose dehydrogenases (FAD‐GDH) as glucose is the aim of the current research. FAD‐GDH is an oxygen‐independent enzyme and has a narrow substrate specificity. For this goal, starches from various sources are tested as a substrate for alpha‐amylase and chose MS‐101 starch as the best substrate, between six different starch types. Under optimal assay conditions, when hydrolyzed starch (in 20 min, 37 °C, pH = 7) reacts with FAD‐GDH enzymes that exist in test strips for 5 s glucometer can show the amount of glucose produced in samples from patient samples. This glucose value is directly correlated with the salivary alpha‐amylase activity (p‐value <0.01).

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Pain intensity and salivary α‐amylase activity in patients following mandibular third molar surgery

Cited by 8 publications

References 40 publications

Non-Invasive Objective Markers to Measure Pain: A Direction to Develop a Pain Device - A Narrative Review

Non-Invasive Objective Markers to Measure Pain: A Direction to Develop a Pain Device - A Narrative Review

Pain intensity and salivary α‐amylase activity in patients following mandibular third molar surgery

A New Strategy for Measuring Salivary Alpha‐Amylase Activity Using Glucometer

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