Pain Perception in Patients With Schizophrenia

Dissociation and pain perception: An experimental investigation

“…For example, individuals with bulimia nervosa were found to have higher pain thresholds in response to both thermal pain stimulation (TPS) and submaximal effort tourniquet test (SETT) than normal controls (de Zwaan, Biener, Bach, Wiesnagrotzki, & Stacher, 1996;de Zwaan, Biener, Schneider, & Stacker, 1996), and similar results were found for individuals with a history of bulimia nervosa whose symptoms were in remission (Stein et al, 2002). Decreased sensitivity to experimentally induced pain has also been reported among individuals with schizophrenia (Blumensohn, Ringle, & Eli, 2002;Dworkin, 1994), and major depression (Dworkin, Clark, & Lipsitz, 1994). In a meta-analysis and review of pain perception and major depression, Dickens, McGowan, and Dale (2003) reported that depressed subjects were less likely to perceive sensory stimuli as painful relative to nondepressed subjects.…”

Signs of bruxism and temporomandibular disorders among patients with bipolar disorder

“…On the other hand, pain or tenderness during palpation of the masseter muscle and joint is not an entirely objective finding, as it is also an expression of a subjective feeling which can lead to the overestimation of the clinical signs. Although pain is the major reason for seeking medical care, difficulties in getting an accurate patient history regarding the BD and differences in pain threshold among all psychiatric disorders must also be considered 37 .…”

Haloperidol and risperidone have specific effects on altered pain sensitivity in the ketamine model of schizophrenia

“…Clinical investigations suggested that schizophrenic patients may have less sensitivity to different pain modalities (Kudoh et al 2000;Dworkin 1994;Bickerstaff et al 1988;Blumensohn et al 2002;Fishbain 1982;Singh et al 2006;Jochum et al 2006). An increased threshold of Cfibre functioning (Kudoh et al 2000) and a dysregulation of NMDA receptor transmission (Olney and Farber 1995) were proposed to account for this phenomenon.…”