Pain relief in laparoscopic tubal ligation using intraperitoneal lignocaine: a double masked randomized controlled trial

Manjunath, Attibele Palaksha; Chhabra, Nidhika; Girija, Shivarudraiah; Nair, Sreekumaran

doi:10.1016/j.ejogrb.2012.06.035

Cited by 14 publications

(10 citation statements)

References 26 publications

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“…5,6 Intra peritoneal instillation of local anesthetic along with local infiltration at the port site leads to more profound analgesia. 3,7,8 Conventionally non-steroidal anti-inflammatory drugs (NSAIDs) are administered for post-operative pain relief. 4,9,10 These drugs act centrally and have limited action on the pain arising from peritoneal irritation, tubal ischemia and diaphragmatic irritation.…”

Section: Discussionmentioning

confidence: 99%

The comparison of the efficacy of intra-peritoneal instillation along with local infiltration with bupivacaine versus placebo for post-operative analgesia after laparoscopic tubal ligation

Kakade

Dudam

Panchanadikar

2019

Int J Reprod Contracept Obstet Gynecol

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Background: Intra-peritoneal instillation of local anesthetics has been shown to minimize post-operative pain after laparoscopic surgeries. The present study was undertaken with the following aim to compare the efficacy of intra-peritoneal instillation and local infiltration with bupivacaine versus placebo for post-operative analgesia after laparoscopic tubal ligation. To correlate the advantages and side effects of the drugs during the procedure. To establish a protocol for the use of bupivacaine instillation and infiltration for post-operative analgesia after laparoscopic tubal ligation.Methods: A prospective study was carried out in a tertiary care hospital attached to a teaching medical institute. Institutional ethics committee approval was obtained for this randomized control study (double blind) including 50 women who will be divided in two groups. Group A will be administered intra-peritoneal bupivacaine along with local infiltration. Group B will be administered normal saline. Post-operative pain will be monitored by a blind observer and rescue analgesia will be administered at visual analogue score of 3.Results: Both the groups were comparable with respect to age and BMI. The mean duration of analgesia in Group A with bupivacaine was 315.60±79.9 min (Median 300 min). The mean duration of analgesia in Group B with normal saline was 138.20±46.97 min (Median 150 min, p value <0.001).Conclusions: The study depicts a significant pain relief after use of bupivacaine. Bupivacaine instillation in the peritoneal cavity along with local infiltration of the drug gives prolongs pain relief as compared to normal saline.

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Section: Discussionmentioning

confidence: 99%

The comparison of the efficacy of intra-peritoneal instillation along with local infiltration with bupivacaine versus placebo for post-operative analgesia after laparoscopic tubal ligation

Kakade

Dudam

Panchanadikar

2019

Int J Reprod Contracept Obstet Gynecol

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“…In the following studies [7], [13], [14], [15] that record the effect of intraperitoneal lidocaine or pulmonary recruitment in abdominal pain after laparoscopic surgeries, the patients had received an oral, intravenous or intraperitoneal analgesic drug from the beginning of the procedure with either pulmonary recruitment or intraperitoneal lidocaine. While in Multi-modal analgesic technique, the patients received two simple and safe manoeuvres.…”

Section: Discussionmentioning

confidence: 99%

“…A previous study that compared intra-peritoneal Lidocaine instillation versus placebo reported 1hour postoperative VAS to be 2.2 vs 4.7 with standard deviation (1.7) [7]. The sample size was calculated using one-way analysis of variance (ANOVA).…”

Section: Methodsmentioning

confidence: 99%

Multi-Modal Analgesic Technique for Pain Control in Patients Undergoing Diagnostic Gynecological Laparoscopy: Randomized Controlled Clinical Trial

Refaat¹,

Mawgood²,

Sonbaty³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Advancement in minimally invasive laparoscopic surgeries make it one of the best choices for both the surgeon and the patient. The anesthesiologist had to improve the techniques used to control post-operative pain. AIM: In this study, we hyposethized that multi-modal analgesic technique which is a combination of two simple techniques (intraperitoneal lidocaine and pulmonary recruitment) allow better result than using only one of them. PATIENTS AND METHOD: This randomised controlled, double-blind study was conducted in Kasr-Alainy hospital, faculty of medicine, Cairo University, Egypt from September 2017 till February 2018. Fifty female patients, scheduled for diagnostic gynecologic laparoscopy were included in the study. Patients were randomly allocated using random computer allocation with numbered closed opaque envelopes into four study group. GM (n = 12): Patients received pulmonary recruitment maneuver and intra-peritoneal Lidocaine, GL (n = 13): Patients received intra-peritoneal Lidocaine, GP (n = 13): Patients received Pulmonary Recruitment Maneuver, GC (n = 12): Patients received passive exsufflation through the port site. In the ward, patients were asked to fulfil a questionnaire about pain severity using (VAS) at 1, 3, 6-hour post-operative both the patients and the anesthesiologist that assess the (VAS) were blind of the patient group RESULTS: Regarding pain score between groups VAS 1 (the primary outcome) was lowest in GM {4.5 (3-5)} in comparison with other groups (P value = 0.015). While VAS 3 & VAS 6 wasn’t statistically significant between groups. Regarding Time of first rescue analgesia; GM {3 (1.75-4)} showed the longest time in between groups (P-value = 0.042). As regard nausea and vomiting; there was no statistically significant difference in in-between groups. CONCLUSION: Application of Multi-modal analgesic technique allows better analgesia for a longer duration than the use of the sole technique for control of abdominal pain in patients undergoing diagnostic gynaecological laparoscopy.

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“…However, direct mesosalpinx injection of lidocaine 40 -200 mg has been reported to provide long-lasting analgesia in laparoscopic tubal sterilisation. 20,21 Manjunath 22 and co-workers studied the effect of laparoscopic tubal ligation using intraperitoneal lignocaine 0.5% 20 mL compared to 20 mL of isotonic saline and found lignocaine instillation is safe and effective method for postoperative pain relief.…”

Section: Discussionmentioning

confidence: 99%

Effect of Pre-Incisional and Mesosalpinx Infiltration of Local Anaesthesia for Post-Operative Analgesia in Bilateral Abdominal Tubectomies- A Randomised Placebo-Controlled Study

Shivanna¹,

Raghuram²

2017

jebmh

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BACKGROUND The aim of the study is to evaluate the effectiveness of subcutaneous pre-incisional and mesosalpinx infiltration of 0.5% bupivacaine in post-operative pain relief. MATERIALS AND METHODS This is a randomised placebo-controlled double-blind study conducted at Bangalore Medical College and Research Institute on 50 patients scheduled for elective tubal ligation by minilaparotomy under general anaesthesia from April to October 2014. Patients were randomised into 2 groups of 25 each by computer generated random list. Group A patients received 0.5% bupivacaine 10 cc pre-incisional subcutaneous and 5 cc in the mesosalpinx, while Group B patients received normal saline infiltration. In this study, the intensity of post-operative pain was assessed using Verbal Rating Scale (VRS). Data collection was done using questionnaire and collected data was analysed by Student's t-test, Chi-square and Fisher Exact test using SPSS software and descriptive statistical programme, p value < 0.01 was considered significant. RESULTS 50 patients were studied in two groups. Age and weight of the patients were comparable between 2 groups. Pain score in recovery room 2, 4, 6, 8, 10 hours post-surgery were significantly less in bupivacaine group (p < 0.005). Time for rescue analgesia is 3.92 ± 1.07 hrs. in Group A compared to 1.32 ± 0.54 in Group B with p < 0.01. CONCLUSION Pre-incisional and mesosalpinx infiltration of 0.5% bupivacaine in abdominal tubectomies by minilaparotomy led to significant reduction of post-operative pain with prolonged period for rescue analgesia.

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Pain relief in laparoscopic tubal ligation using intraperitoneal lignocaine: a double masked randomized controlled trial

Cited by 14 publications

References 26 publications

The comparison of the efficacy of intra-peritoneal instillation along with local infiltration with bupivacaine versus placebo for post-operative analgesia after laparoscopic tubal ligation

The comparison of the efficacy of intra-peritoneal instillation along with local infiltration with bupivacaine versus placebo for post-operative analgesia after laparoscopic tubal ligation

Multi-Modal Analgesic Technique for Pain Control in Patients Undergoing Diagnostic Gynecological Laparoscopy: Randomized Controlled Clinical Trial

Effect of Pre-Incisional and Mesosalpinx Infiltration of Local Anaesthesia for Post-Operative Analgesia in Bilateral Abdominal Tubectomies- A Randomised Placebo-Controlled Study

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