PAIN THRESHOLD AND BRAIN ENDORPHIN LEVELS IN GENETICALLY OBESE (ob/ob) AND OPIATE RECEPTOR DEFICIENT (CXBK) MICE

Roy, B.P.; Cheng, Regina; Phelan, J.J.; Pomeranz, Bruce

doi:10.1016/b978-0-08-025488-3.50078-7

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…The first observation of altered nociception in these models of obesity dates back to the 1980′s in an abstract reporting higher response thresholds in ob / ob mice; a possible relation with elevated pituitary endorphins levels was hypothesized ( Roy et al, 1980 ). The majority of the studies included in this systematic review aligned with this early finding showing either increased response latencies or thresholds to noxious stimuli or no differences between obese and control animals.…”

Section: Discussionmentioning

confidence: 99%

Diet, body weight and pain susceptibility – A systematic review of preclinical studies

Miranda

Campos

Leite‐Almeida

2021

Neurobiology of Pain

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Highlights Obesity has been associated with increased susceptibility to chronic pain. Dietary and genetic models of obesity have been used to study this association. Allodynia is a common finding but alterations in nociception were inconsistent across studies. In subacute/chronic models, nocifencive behaviors were increased and/or sustained. Reviewed studies are overall consonant with the clinical literature.

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Section: Discussionmentioning

confidence: 99%

Diet, body weight and pain susceptibility – A systematic review of preclinical studies

Miranda

Campos

Leite‐Almeida

2021

Neurobiology of Pain

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Scientific Basis of Acupuncture

Pomeranz

Berman

2003

Basics of Acupuncture

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Opioids and behavior: genetic aspects

1988

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Three animal models, based on genetic differences in endogenous opioid peptides and opioid receptors, are described. Obese mice and rats, whose pituitary opioid content is elevated, may be used to investigate eating disorders. Recombinant inbred strains of mice, which differ in brain opioid receptors and analgesic responsiveness, can be used for study of opioid- and nonopioid-mediated mechanisms of pain inhibition. Individual reactivity to opioids can be examined in C57BL/6 and DBA/2 inbred strains of mice. A model that combines a variety of opioid effects is offered and suggests the existence of a genetically determined dissociation of opioid effects on locomotor activity and pain inhibition. In addition, stimulatory locomotor responses in the C57BL/6 reaction type are linked to a high risk of drug addiction and facilitatory effects on adaptive processes, while high analgesic potency in the DBA/2 reaction type is accompanied by a low proneness to drug abuse and amnesic properties of opioids.

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PAIN THRESHOLD AND BRAIN ENDORPHIN LEVELS IN GENETICALLY OBESE (ob/ob) AND OPIATE RECEPTOR DEFICIENT (CXBK) MICE

Cited by 3 publications

References 7 publications

Diet, body weight and pain susceptibility – A systematic review of preclinical studies

Diet, body weight and pain susceptibility – A systematic review of preclinical studies

Scientific Basis of Acupuncture

Opioids and behavior: genetic aspects

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