Paired distribution of molecular subtypes in bilateral breast carcinomas

Russnes, Hege G.; Kuligina, Ekatherina Sh.; Suspitsin, Evgeny N.; Voskresenskiy, Dmitry A.; Jordanova, Ekaterina S.; Cornelisse, Cees J.; Børresen-Dale, Anne Lise; Imyanitov, Evgeny N.

doi:10.1016/j.cancergencyto.2010.09.012

Cited by 14 publications

(16 citation statements)

References 16 publications

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“…2). This trend is consistent with the previous studies involving paired biBC samples [5][6][7][8]. One of the explanations of phenotypic concordance of the tumors within biBC pairs includes possible metastatic nature of a subset of contralateral BC.…”

Section: Discussionsupporting

confidence: 92%

“…biBC and unilateral BCs (uBC) demonstrate similar distribution of clinical and morphological disease features. Synchronous biBC pairs often show a noticeable concordance of tumor histology, expression characteristics, and patterns of somatic mutations, which can be attributed to nearly identical natural histories of simultaneously arising neoplasms [5][6][7][8]. Metachronous biBCs share genetic background of the host; however, some essential circumstances of tumor development may differ between the first and second neoplasms.…”

Section: Introductionmentioning

confidence: 95%

“…Metachronous biBCs share genetic background of the host; however, some essential circumstances of tumor development may differ between the first and second neoplasms. Age interval may contribute to dissimilarity of metachronous biBC, especially if the disease onsets are separated by menopause [5,7,8]. There is also a survival bias, which selects for metachronous contralateral BC only those patients whose first cancer behaved favorably, and thus provided sufficient time interval to develop the second disease [9].…”

Section: Introductionmentioning

confidence: 96%

“…biBC molecular characteristics have already been described with respect to genomic abnormalities, p53 mutations, oncogene amplifications, and expression of the subtype-specific markers [5,6,8,9,12]. The last decade brought into attention a novel class of molecules with a broad role in cancer development, i.e., microRNAs (miRs).…”

Section: Introductionmentioning

confidence: 99%

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High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas

Iyevleva

Kuligina

Mitiushkina

et al. 2011

Breast Cancer Res Treat

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We analyzed the expression of several microRNAs (miRs) implicated in breast cancer (BC) pathogenesis (miR-21, miR-10b, miR17-5p, mir-31, miR-155, miR-200c, miR-18a, miR-205, and miR-27a) in 80 breast carcinomas obtained from patients with bilateral BC (biBC) and 40 cases of unilateral BC (uBC). Unexpectedly, three miRs (miR-21, miR-10b and miR-31) demonstrated significantly higher level of expression in biBC vs. uBC (P = 0.0001, 0.00004 and 0.0002, respectively). Increased contents of miR-21, miR-10b and miR-31 were observed in all categories of biBC tumors, i.e., in synchronous biBC as well as in first and second tumors from metachronous biBC cases. Synchronous biBC showed more similarity of miR expression profiles within pairs that the metachronous doublets (P = 0.004). This study suggests that bilateral breast tumors have somewhat distinct pattern of molecular events as compared to the unilateral disease.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas

Iyevleva

Kuligina

Mitiushkina

et al. 2011

Breast Cancer Res Treat

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“…Identification of multifocality or bilaterality in breast carcinomas is not uncommon [46,47]. Patients with multiple tumor foci display higher incidence of lymph node positivity than unifocal tumors [46,48].…”

Section: Discussionmentioning

confidence: 99%

A comprehensive morphological study for basal-like breast carcinomas with comparison to nonbasal-like carcinomas

2012

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BackgroundBreast carcinomas can be classified into five subtypes based on gene expression profiling or immunohistochemical characteristics. Among these subtypes, basal-like breast carcinomas (BLBCs) are one of the most studied group, due to their poor prognosis. The aim of this study was to investigate the prevalance, morphological and immunohistochemical features of BLBCs, in Turkish population.MethodsFive hundred invasive breast carcinomas were reviewed for several morphological features and immunostained for oestrogen and progesterone receptors, c-ERB-B2, cytokeratin5/6, cytokeratin14, vimentin and epidermal growth factor receptor (EGFR). Basal-like breast carcinoma was defined as a triple negative tumor with cytokeratin5/6 and/or EGFR positive.ResultsThe prevalance of BLBC was 9.6%. All medullary carcinomas and 55.6% of metaplastic carcinomas showed basal-like immunophenotype. Patients with BLBC were younger (p=0.04) and had higher-grade tumors (p<0.0001). Morphologic features associated with BLBC included increased mitosis, nuclear pleomorphism, presence of geographic and/or central necrosis, pushing margin of invasion and stromal lymphocytic response (p<0.0001). Presence of prominent nucleoli and vesicular nuclear chromatin were the cytological features correlated with basal-like phenotype (p<0.0001). On multivariate analyses, BLBCs were associated with high mitotic number (p<0.0001), the presence of vesicular chromatin (p=0.004), high tubular grade (p=0.011), lymphocytic response (p=0.031) and the absence of carcinoma insitu (p=0.039). Vimentin was positive in 53.2% of BLBCs, while cytokeratin14 was less frequently expressed (27.7%).ConclusionsBLBCs have some distinctive, but not pathognomonical, morphological features. Paying attention to these features and adding cytokeratin14 and vimentin to the immunohistochemical panel can help the definitive diagnosis of BLBCs.Virtual slideHttp://www.diagnosticpathology.diagnomx.eu/vs/5962175467857400

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High prevalence and breast cancer predisposing role of the BLM c.1642 C>T (Q548X) mutation in Russia

Sokolenko

Iyevleva

Preobrazhenskaya

et al. 2011

Intl Journal of Cancer

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The BLM gene belongs to the RecQ helicase family and has been implicated in the maintenance of genomic stability. Its homozygous germline inactivation causes Bloom syndrome, a severe genetic disorder characterized by growth retardation, impaired fertility and highly elevated cancer risk. We hypothesized that BLM is a candidate gene for breast cancer (BC) predisposition. Sequencing of its entire coding region in 95 genetically enriched Russian BC patients identified two heterozygous carriers of the c.1642 C>T (Q548X) mutation. The extended study revealed this allele in 17/1,498 (1.1%) BC cases vs. 2/1,093 (0.2%) healthy women (p 5 0.004). There was a suggestion that BLM mutations were more common in patients reporting first-degree family history of BC (6/251 (2.4%) vs. 11/1,247 (0.9%), p 5 0.05), early-onset cases (12/762 (1.6%) vs. 5/736 (0.7%), p 5 0.14) and women with bilateral appearance of the disease (2/122 (1.6%) vs. 15/1376 (1.1%), p 5 0.64). None of the BLM-associated BC exhibited somatic loss of heterozygosity at the BLM gene locus. This study demonstrates that BLM Q548X allele is recurrent in Slavic subjects and may be associated with BC risk.Hereditary risk factors are strongly implicated in breast cancer (BC) predisposition. Mutations in BRCA1 and BRCA2 genes account for approximately 15-20% of familial BC clustering among first degree relatives.

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Paired distribution of molecular subtypes in bilateral breast carcinomas

Cited by 14 publications

References 16 publications

High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas

High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas

A comprehensive morphological study for basal-like breast carcinomas with comparison to nonbasal-like carcinomas

High prevalence and breast cancer predisposing role of the BLM c.1642 C>T (Q548X) mutation in Russia

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