Paired related homeobox 1 attenuates autophagy via acetyl‐CoA carboxylase 1‐regulated fatty acid metabolism in salivary adenoid cystic carcinoma

Abstract

Autophagy can affect the invasion and metastasis of carcinoma. Our previous study has shown that invasion and epithelial‐mesenchymal transition in salivary adenoid cystic carcinoma (SACC) can be promoted by the metabolic reprogramming of free fatty acids (FFAs). However, the effect of FFA metabolism on autophagy in SACC remains unknown. In this study, we showed that overexpression of paired related homeobox 1 (PRRX1) reduced the number of autophagosomes and decreased the expression of LC3 and Beclin‐1 in SACC patients and SACC‐83 cells in vitro. Moreover, PRRX1‐mediating FFA reprogramming triggered to autophagy via regulating acetyl‐CoA carboxylase 1 (ACC1), leading to invasion and migration in SACC.

Inhibition of adenoid cystic carcinoma cell proliferation and migration through autophagy inhibition via GLUT1 knockdown

“…Recent studies have demonstrated that autophagy is involved in tumorigenesis, tumor development, and chemoradiotherapy resistance [19,[24][25][26]. Investigations of autophagy in patients with ACC have revealed that autophagy-related genes are involved in ACC tumorigenesis and can serve as prognostic factors [6,7,[27][28][29][30][31]. Moreover, autophagy inhibition can improve ACC chemosensitivity [30].…”