Paired values of serum fructosamine and blood glucose for the screening of gestational diabetes mellitus: A retrospective study of 165 Saudi pregnant women

Khan, Haseeb A.; Sobki, Samia H.; Alhomida, Abdullah S.; Khan, Shaukat

doi:10.1007/bf02912884

Cited by 8 publications

(10 citation statements)

References 34 publications

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“…A short-term marker of glycemia is needed in GDM because HbA1c measurements are not reliable as glucose and iron concentrations decrease while erythrocyte turnover increases [290,291]. Fructosamine is a preferred alternative because it can be obtained from a single random blood sample and does not require an OGTT [292]. However, fructosamine was insensitive for identifying GDM in early pregnancy [293] .…”

Section: Fructosaminementioning

confidence: 99%

Review of methods for detecting glycemic disorders

Bergman

Abdul‐Ghani

Manco

et al. 2020

Diabetes Research and Clinical Practice

134

101

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Highlights A 1-hour plasma glucose (1-h PG) threshold >155 mg/dl (8.6 mmol/L) during an oral glucose tolerance test (OGTT) may be a suitable biomarker for identifying normal glucose tolerant (NGT) individuals at risk for future type 2 diabetes (T2D). A one-hour, non-fasting, 50g Glucose Challenge Test (GCT) performed during a routine health care visit has potential for practical screening of glucose disorders. The shape of the glucose curve reflects the cumulative effect of insulin sensitivity and response on glucose concentrations with prospective studies warranted to evaluate its prognostic utility. The continuous glucose monitor (CGM) has facilitated insight into the pathophysiology of prediabetes and phenotypes of T2D and holds promise for detecting glycemic disorders. Metabolomic profiling including amino acids, lipids, carbohydrates and other metabolites may be useful for early diagnosis of glycemic disorders. Non-classical markers for assessing glycemic disorders including fructosamine, glycated albumin, and 1,5-anhydroglucitol that evaluate shorter periods of glucose exposure than HbA1c have potential use as adjunctive tools.

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Section: Fructosaminementioning

confidence: 99%

Review of methods for detecting glycemic disorders

Bergman

Abdul‐Ghani

Manco

et al. 2020

Diabetes Research and Clinical Practice

134

101

View full text Add to dashboard Cite

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“… 64 Other researchers have utilized the serum fructosamine and blood glucose for the screening of GDM. 36 , 37 Both these tests allow the health-care providers to establish whether the pregnant women, with associated risk facts, had developed diabetes before the pregnancy, which may have gone undiagnosed. If the HbA1c levels are not monitored closely to establish acceptable glycemic control, the higher levels of HbA1c may cause the long-axis cardiac dysfunction in the developing fetus.…”

Section: Hba1c Rangementioning

confidence: 99%

“…Although paired values of blood glucose and serum fructosamine were also reported for the screening of GDM, there were significant fluctuations during several antenatal visits. 36,37 Prognostic Potentials of HbA1c…”

Section: Diagnostic Potentials Of Hba1cmentioning

confidence: 99%

Significance of HbA1c Test in Diagnosis and Prognosis of Diabetic Patients

et al. 2016

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Diabetes is a global endemic with rapidly increasing prevalence in both developing and developed countries. The American Diabetes Association has recommended glycated hemoglobin (HbA1c) as a possible substitute to fasting blood glucose for diagnosis of diabetes. HbA1c is an important indicator of long-term glycemic control with the ability to reflect the cumulative glycemic history of the preceding two to three months. HbA1c not only provides a reliable measure of chronic hyperglycemia but also correlates well with the risk of long-term diabetes complications. Elevated HbA1c has also been regarded as an independent risk factor for coronary heart disease and stroke in subjects with or without diabetes. The valuable information provided by a single HbA1c test has rendered it as a reliable biomarker for the diagnosis and prognosis of diabetes. This review highlights the role of HbA1c in diagnosis and prognosis of diabetes patients.

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“…As in other clinical settings, mixed evidence has been reported on the utility of fructosamine in screening and monitoring of gestational diabetes mellitus. Khan et al measured FPG and serum fructosamine in 165 pregnant women, 71 and found that FPG and fructosamine could identify high-risk individuals to be screened with the OGTT avoiding unnecessary glucose challenges. At variance with these findings, Li et al measured fructosamine in 161 pregnant women, 72 and reported that this biomarker may be useful for identifying patients at higher risk of abnormal glucose tolerance, but could not be used to predict gestational diabetes mellitus in early pregnancy due to the poor correlations with the outcome of the OGTT.…”

Section: Clinical Studies About Glycated Albumin and Fructosaminementioning

confidence: 99%

Advantages and Pitfalls of Fructosamine and Glycated Albumin in the Diagnosis and Treatment of Diabetes

Danese

Montagnana

Nouvenne

et al. 2015

J Diabetes Sci Technol

167

139

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Diabetes is one of the most severe and frequent human disorders. According to recent statistics, this condition afflicts as many as 382 million persons around the globe, with an estimated prevalence of approximately 8.3% in 2013. At variance with other frequent pathologies such as cardiovascular disease and bacterial infections, the trend toward an increased prevalence is not expected to soon reverse. Worldwide, as many as 592 million individuals may be affected by diabetes in 2035, a remarkable 55% increase in prevalence over the next 2 decades. 1 Due to its high global prevalence and severe, frequently life-threatening complications (eg, retinopathy, nephropathy, neuropathy, cardiovascular disease), diabetes must be regarded as a serious and increasing global health burden. The most recent Standards of Medical Care in Diabetes published by the American Diabetes Association (ADA) emphasize that early diagnosis and monitoring are critical for preventing or delaying the onset of acute complications and lowering the risk of long-term complications of diabetes. 2 The current diagnostic criteria for this condition are based on the presence of (1) glycated hemoglobin (HbA1c) value ≥6.5% (ie, ≥48 mmol/mol), (2) fasting plasma glucose (FPG) ≥126 mg/dL (ie, ≥7.0 mmol/L), (3) 2-hour plasma glucose ≥200 mg/dL (ie, ≥11.1 mmol/L) during an oral glucose tolerance test (OGTT) using a 75 g glucose load, or (4) random plasma glucose ≥200 mg/dL (ie, ≥11.1 mmol/L). An increased risk of diabetes (ie, prediabetes) is defined in the presence of (1) HbA1c value between 5.7-6.4% (ie, 39-46 mmol/mol), (2) FPG between 100-126 mg/dL (ie, 5.6-6.9 mmol/L), (3) 2-hour plasma glucose between 140-199 mg/ dL (ie, 7.8-11.0 mmol/L) during an OGTT. With regard to diabetes monitoring, the glycemic targets for nonpregnant adults with diabetes include HbA1c value <7.0% (ie, <53 mmol/mol), preprandial capillary plasma glucose between 567227D STXXX10.

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Paired values of serum fructosamine and blood glucose for the screening of gestational diabetes mellitus: A retrospective study of 165 Saudi pregnant women

Abstract: This study reports the utilization of serum fructosamine and blood glucose for the screening of gestational diabetes mellitus (GDM).

Cited by 8 publications

References 34 publications

Review of methods for detecting glycemic disorders

Review of methods for detecting glycemic disorders

Significance of HbA1c Test in Diagnosis and Prognosis of Diabetic Patients

Advantages and Pitfalls of Fructosamine and Glycated Albumin in the Diagnosis and Treatment of Diabetes

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