Palladated and platinated complexes derived from phenylacetaldehyde thiosemicarbazone with cytotoxic activity in cis-DDP resistant tumor cells. Formation of DNA interstrand cross-links by these complexes

Palladium(II) complexes with thiosemicarbazones: syntheses, characterization and cytotoxicity against breast cancer cells and Anti-Mycobacterium tuberculosis activity

“…In fact, the literature reports that palladium(II) and platinum(II) complexes of thiosemicarbazone derivatives are able to bind to DNA in vitro, and present enhanced capacity to form interstrand crosslinks when compared to cisplatin. 30,31 Additionally, the presence of a phosphine ligand may also contribute to higher activity. 32 On the other hand, the free thiosemicarbazones could present antitumor effect by inhibiting DNA syntheses through the blockage of the enzyme ribonucleoside diphosphate reductase (RDR), which catalyses the conversion of ribonucleotides into desoxyribonucleotides, as proposed for other α(N)-heterocyclic thiosemicarbazones.…”

Cisplatin Damage: Are DNA Repair Proteins Saviors or Traitors to the Cell?

“…[21] And furthermore, why is the antineoplastic effect of cisplatin restricted to certain tumor types (for example, testicular cancer)? Maybe the distinct targeted cells/organs differ in one or more of the parameters mentioned above (or in other characteristics not yet detected), thereby rendering them differentially susceptible to cisplatin.…”

Synthesis, characterization, DNA- Binding Interaction studies and antimicrobial screening mixed-ligand Cu (II) and Mn (II) complexes

“…The ligand L1(phenyl-3-methyl-5-pyrazolone Semicarbazone) was prepared by the reaction of (benzaldehyde) with (Simecarbazide), according to the literature (17) . …”