Palladium complexes of 2-formylpyridine thiosemicarbazone and two related ligands: Synthesis, structure and, spectral and catalytic properties

Paul, Piyali; Butcher, Ray J.; Bhattacharya, Samaresh

doi:10.1016/j.ica.2014.10.010

Cited by 36 publications

(43 citation statements)

References 59 publications

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“…Perhaps the structural rigidity of the Cu 2 (OAc) 4 core precludes coordination by anything except a monodentate ligand. Normally the reaction of such a ligand with Cu(II) in a ration 2:1 ratio ligand:copper would lead to a bis-chelate CuN 2 O 2 complex with this reaction being assisted by deprotonation at N3a by a base suchA C C E P T E D M A N U S C R I P Tas Et 3 N, NaOH or NaOMe although base is not always required[62][63][64][65]. In this reaction the acetate anions could potentially accept a proton from N3a but instead they are consumed stoichiometrically in forming the Cu 2 (OAc) 4 cluster.…”

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confidence: 99%

Synthesis, characterization and biological activities of semicarbazones and their copper complexes

Venkatachalam

Bernhardt

Noble

et al. 2016

Journal of Inorganic Biochemistry

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Substituted semicarbazones/thiosemicarbazones and their copper complexes have been prepared and several single crystal structures examined. The copper complexes of these semicarbazone/thiosemicarbazones were prepared and several crystal structures examined. The single crystal X-ray structure of the pyridyl-substituted semicarbazone showed two types of copper complexes, a monomer and a dimer. We also found that the p-nitrophenyl semicarbazone formed a conventional 'magic lantern' acetate-bridged dimer. Electron Paramagnetic Resonance (EPR) of several of the copper complexes was consistent with the results of single crystal X-ray crystallography. The EPR spectra of the p-nitrophenyl semicarbazone copper complex in dimethylsulfoxide (DMSO) showed the presence of two species, confirming the structural information. Since thiosemicarbazones and semicarbazones have been reported to exhibit anticancer activity, we examined the anticancer activity of several of the derivatives reported in the present study and interestingly only the thiosemicarbazone showed activity while the semicarbazones were not active indicating that introduction of sulphur atom alters the biological profile of these thiosemicarbazones.

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confidence: 99%

Synthesis, characterization and biological activities of semicarbazones and their copper complexes

Venkatachalam

Bernhardt

Noble

et al. 2016

Journal of Inorganic Biochemistry

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“…Tetradentate thiosemicabazone with strong DNA-binding ability was isolated after the condensation of pyruvaldehyde with 4-(aryl)-thiosemicarbazones [34]. The use of thiosemicarbazones are also utilized as catalyst [35,36] and possess significant mushroom tyrosinase inhibiton activities [37]. A variety of thiosemicarbazone [38][39][40] have been involved in the treatment of trypanosomiasis caused by Trypanosoma cruzi parasite.…”

Section: Biological Importance Of Semicarbazones and Thiosemicarbazonesmentioning

confidence: 99%

Biological Applications of Co(II) and Ni(II) Complexes of Semicarbazones and Thiosemicarbazones

Jain¹,

Kumar²,

Chandra³

2018

Asian J. Chem.

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“…Over several decades the chemistry of thiosemicarbazone and their complexes have attracted the interest of numerous researchers due to their facile synthesis and wide biological, analytical, catalytic and pharmaceutical applications. [11][12][13][14][15] Due to their outstanding characteristics and structural resemblances with natural biological substances, many thiosemicarbazone ligands and their metal complexes have acquired a broad spectrum of biological activities like antibacterial, [11] antifungal, [16] anti-trypanosomal, [17] anti-proliferative, [18,19] antiviral, [20] anti-tubercular, [21] anticonvulsant, [22] antioxidant [23,24] antitumor, [11,[24][25][26] antiamoebic [27] and antimalarial activities. [28] Some thiosemicarbazone derivatives displayed a remarkable and eclectic activity toward tumor xenografts in nude mice.…”

Section: Introductionmentioning

confidence: 99%

Anti‐proliferative activity of newly synthesized Cd(II), Cu(II), Zn(II),Ni(II), Co(II), VO(II), and Mn(II) complexes of 2‐((4,9‐dimethoxy‐5‐oxo‐5H‐furo[3,2‐g]chromen‐6‐yl)methylene) hydrazinecarbothioamide on three human cancer cells

Shakdofa

Mousa

Elseidy

et al. 2017

Applied Organom Chemis

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Thiosemicarbazone ligand, 2-((4,9-dimethoxy-5-oxo-5H-furo[3,2-g]chromen-6-yl) methylene) hydrazinecarbothioamide and its Cd(II), Cu(II), Zn(II), Ni(II), Co(II), VO(II), and Mn(II) complexes have been prepared and characterized by various spectroscopic and analytical techniques. Complexes molar conductance measurements displayed that all complexes (2-8) are non-electrolyte. With general compo-Based on analytical and spectral measurements, the octahedral or distorted octahedral geometries suggested for complexes. Ligand and complexes anti-proliferative activities were assessed against three various human tumor cell lines including breast cancer (MCF-7), liver cancer (HepG2) and lung cancer (A549) using SRB fluorometric assay and cis-platin as positive control. The anti-proliferative activity result indicated that the ligand and its complexes have considerable anti-proliferative activity analogous to that of ordinarily utilized anti-cancer drug (cis-platin). They do their anti-cancer activities by modifying free radical's generation via raising the superoxide dismutase activity and depletion of intracellular reduced glutathione level, catalase, glutathione peroxidase activities, escorted by highly generation of hydrogen peroxide, nitric oxide and other free radicals leading to tumor cells death, as monitoring by decreasing the protein and nucleic acids synthesis.

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Palladium complexes of 2-formylpyridine thiosemicarbazone and two related ligands: Synthesis, structure and, spectral and catalytic properties

Cited by 36 publications

References 59 publications

Synthesis, characterization and biological activities of semicarbazones and their copper complexes

Synthesis, characterization and biological activities of semicarbazones and their copper complexes

Biological Applications of Co(II) and Ni(II) Complexes of Semicarbazones and Thiosemicarbazones

Anti‐proliferative activity of newly synthesized Cd(II), Cu(II), Zn(II),Ni(II), Co(II), VO(II), and Mn(II) complexes of 2‐((4,9‐dimethoxy‐5‐oxo‐5H‐furo[3,2‐g]chromen‐6‐yl)methylene) hydrazinecarbothioamide on three human cancer cells

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