Palladium(II) complexes bearing N,O-bidentate Schiff base ligands: Experimental, in-silico, antibacterial, and catalytic properties

Rosnizam, Arif Naim; Hamali, Muhamad Azwan; Low, Anis Low Muhammad; Anouar, El Hassane; Youssef, Hany M.; Bahron, Hadariah; Tajuddin, Amalina Mohd

doi:10.1016/j.molstruc.2022.132821

Cited by 11 publications

(14 citation statements)

References 56 publications

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“…The antibacterial activity screening test was conducted according to previously reported procedure . Both metal complexes and their parent ligand were screened against two Gram-positive bacteria, Staphylococcus aureus subsp.…”

Section: Resultsmentioning

confidence: 99%

“…33 The second large contribution is the C The antibacterial activity screening test was conducted according to previously reported procedure. 11 Both metal complexes and their parent ligand were screened against two Gram-positive bacteria, Staphylococcus aureus subsp. aureus Rosenbach (ATCC 6538) and Streptococcus mutans Clarke (ATCC 700,610) and a Gramnegative bacterium, Proteus vulgaris (ATCC 6380).…”

Section: Physicochemical and Spectroscopic Characterizationmentioning

confidence: 99%

“…9 Besides, the Pd(II) Schiff base complex exhibited a slight activity against Gram-negative bacteria P. aeruginosa (ATCC 10145) and S. sonnei (ATCC 25931). 11 Schiff bases with hydroxyl and azomethine chromophores tend to have hydrogen bonding with active centers of cells of the cell membrane, resulting in higher permeability. 9 Based on antibacterial result reported by and Rosnizam et al (2022), both metal complexes were generally observed to be more pronounced than their parent ligands against the tested bacterial strains.…”

Section: Introductionmentioning

confidence: 99%

“…11 Schiff bases with hydroxyl and azomethine chromophores tend to have hydrogen bonding with active centers of cells of the cell membrane, resulting in higher permeability. 9 Based on antibacterial result reported by and Rosnizam et al (2022), both metal complexes were generally observed to be more pronounced than their parent ligands against the tested bacterial strains. 9,11 The antibacterial activities of the metal complexes against various kinds of Gram-positive and Gram-negative bacterial strains are enhanced owing to the chelation process.…”

Section: Introductionmentioning

confidence: 99%

“…Palladium(II) and nickel(II) Schiff base complexes have been known for their biological potential in the treatment of various diseases. − According to Kargar et al (2022), the Ni(II) complex has found to be a good inhibitor for S. aureus , where the inhibition performance of the Ni(II) complex is as good as the antibiotic Erythromycin against that Gram-positive bacterial strains . Besides, the Pd(II) Schiff base complex exhibited a slight activity against Gram-negative bacteria P. aeruginosa (ATCC 10145) and S. sonnei (ATCC 25931) …”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Structural Characterization, Hirshfeld Surface Analysis, and Antibacterial Study of Pd(II) and Ni(II) Schiff Base Complexes Derived from Aliphatic Diamine

et al. 2022

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A Schiff base bearing two methyl substituents, namely, 6,6′-((1E,1′E)-((2,2-dimethylpropane-1,3-diyl) bis(azanylylidene)) bis(methanylylidene)) bis(2-methylphenol) [H2AD1Me] was synthesized and characterized through physicochemical and spectroscopic analyses. Then, the Schiff base was complexed with Pd(II) and Ni(II) to form [Pd(AD1Me)] and [Ni(AD1Me)], respectively. Both metal complexes were successfully obtained and characterized through several analyses, viz., melting point, elemental analysis, molar conductivity, magnetic susceptibility, FTIR, 1H NMR, UV–vis, and single crystal X-ray diffraction. A quantitative analysis of the intermolecular interactions in the crystal structures has been performed using Hirshfeld surface analysis. Both metal complexes were crystallized in a monoclinic crystal system with the space group of P21/c. Additionally, the deprotonated phenolic oxygen atom (O1/O2) and azomethine nitrogen atom (N1/N2) of the ligand chelate the Pd(II) and Ni(II) ions, forming a slightly distorted square-planar complex containing three six-membered rings encircling the metal core with dsp2 hybridization. The shift of ν(CN) to a higher frequency in FTIR by 26–28 cm–1 indicated that the complexation to Pd(II) and Ni(II) through the azomethine N was established. It was further supported through the shifting of the azomethine proton signal to higher or lower chemical shifts with Δδ = 0.43–1.15 ppm in 1H NMR. In addition, the shifting of the n−π*(CN) band in UV–vis spectra with Δλ = 24–40 nm indicated the involvement of azomethine nitrogen in the complexation. All the compounds showed no significant antibacterial activity against three bacterial strains, namely, Staphylococcus aureus subsp. aureus Rosenbach (ATCC 6538), Streptococcus mutans Clarke (ATCC 700,610), and Proteus vulgaris (ATCC 6380), as the percent growth inhibition calculated was less than 90%.

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Section: Resultsmentioning

confidence: 99%

Section: Physicochemical and Spectroscopic Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis, Structural Characterization, Hirshfeld Surface Analysis, and Antibacterial Study of Pd(II) and Ni(II) Schiff Base Complexes Derived from Aliphatic Diamine

et al. 2022

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A polynuclear Cu^IIBi^III complex with antipyrine‐derived Schiff‐base: Preparation, characterization, and biological evaluations

Jiang

Liu

et al. 2023

Applied Organom Chemis

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Schiff base {(E)‐4‐((2‐hydroxy‐3‐methoxybenzylidene)amino)‐1,5‐dimethyl‐2‐phenyl‐1,2‐dihydro‐3H‐pyrazol‐3‐one} was prepared by the condensation reaction between 2‐hydroxy‐3‐methoxybenzaldehyde and 4‐aminoantipyrine. In the process of forming the title complex, Schiff base was first coordinated with CuII ions to form the mononuclear CuII complex (abbreviated as the complex (I)). Next, Schiff base in the complex (I) removed a phenyl group and then changed from the amide to the iminol. The tautomer further formed the complex through the iminol oxygen, and the phenolic oxygen coordinated with metal ions (CuII and BiIII). The structure of the polynuclear CuIIBiIII complex (abbreviated as the complex (II)) was identified as [Bi2Cu6 L6O3] (L = C13H13N3O3) by elemental analysis, FT‐IR spectra, and single‐crystal X‐ray diffraction analysis. The antibacterial effect of Schiff base and its complex (II) were assessed on four bacterial strains involving gram‐positive strains (S. aureus and B. subtilis) and gram‐negative strains (E. coli and P. aeruginosa). The complex (II) exhibited stronger antibacterial activity than Schiff base. Assessment of cytotoxic activity against SNU‐16 cells (Human gastric cancer) has demonstrated that the complex (II) was more active than Schiff base, and their IC50 values were 0.29 and 1.83 μM, respectively.

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Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex

Jahangiry,

Lashanizadegan,

Pourhosseini

et al. 2024

Biometals

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Schiff base complexes play a crucial role in bioinorganic chemistry. A novel curcumin/phenylalanine tridentate Schiff base ligand and its palladium (II) complex were synthesized in order that they were stable in aqueous buffer. The structure of the complex was investigated using a variety of methods, including DFT, NBO analysis, FMOs, and MESP. The interaction of the complex with plasmid (pUC19) and CT-DNA was studied. The anticancer, antibacterial, and antioxidant activities of the complex were examined. The statistical analysis of MTT assay was compared using the 1-way ANOVA and Tukey test. Results showed that the complexes were stable in aqueous buffer, pH 8. The extrinsic fluorescence emission of the plasmid and CT-DNA was quenched while interacting with the complex. The complex had an IC50 of 72.47 μM against MCF-7 cells. The ANOVA and Tukey analysis of MTT data demonstrated a statistically significant difference between groups (P<0.0001). The minimum inhibitory concentrations (MIC) of the complex for E. coli and S. aureus were 300 and 200 μg/mL, with 96.3 % and 95.2 % biofilm growth inhibition at 250 μg/mL, respectively. The sample concentrations contributing to 50% radical inhibition in the 1,1-diphenyl-2picrylhydrazyl (DPPH) test for curcumin, ligand, and palladium (II) complex were 33.62, 21.27, and 51.26 μM, respectively. The results suggest that the complex interaction with DNA is one of the potential mechanisms in the elimination of cancer cells and bacteria in the planktonic and biofilm. On the other hand, while stability in aqueous buffer at pH 8 increases, modified curcumin antioxidant effect decreases.

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Palladium(II) complexes bearing N,O-bidentate Schiff base ligands: Experimental, in-silico, antibacterial, and catalytic properties

Cited by 11 publications

References 56 publications

Synthesis, Structural Characterization, Hirshfeld Surface Analysis, and Antibacterial Study of Pd(II) and Ni(II) Schiff Base Complexes Derived from Aliphatic Diamine

Synthesis, Structural Characterization, Hirshfeld Surface Analysis, and Antibacterial Study of Pd(II) and Ni(II) Schiff Base Complexes Derived from Aliphatic Diamine

A polynuclear Cu^IIBi^III complex with antipyrine‐derived Schiff‐base: Preparation, characterization, and biological evaluations

Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex

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Palladium(II) complexes bearing N,O-bidentate Schiff base ligands: Experimental, in-silico, antibacterial, and catalytic properties

Cited by 11 publications

References 56 publications

Synthesis, Structural Characterization, Hirshfeld Surface Analysis, and Antibacterial Study of Pd(II) and Ni(II) Schiff Base Complexes Derived from Aliphatic Diamine

Synthesis, Structural Characterization, Hirshfeld Surface Analysis, and Antibacterial Study of Pd(II) and Ni(II) Schiff Base Complexes Derived from Aliphatic Diamine

A polynuclear CuIIBiIII complex with antipyrine‐derived Schiff‐base: Preparation, characterization, and biological evaluations

Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex

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Product

Resources

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A polynuclear Cu^IIBi^III complex with antipyrine‐derived Schiff‐base: Preparation, characterization, and biological evaluations