Palladium(II) Complexes of NS Donor Ligands Derived from Steroidal Thiosemicarbazones as Antibacterial Agents

Abstract

We have investigated the antibacterial activity of some new steroidal thiosemicarbazones and their Pd(II) metal complexes were prepared by the reaction of the thiosemicarbazones with [Pd(DMSO)2Cl2]. The steroidal thiosemicarbazones were prepared by the reaction of thiosemicarbazides with a steroidal ketone. The structures of these compounds were elucidated by IR, 1H-NMR, 13C-NMR, FAB mass spectroscopic methods, elemental analyses and TGA analysis. The antibacterial activity of these compounds were tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria. The results showed that steroidal complexes are better inhibitors of both types of the bacteria (Gram-positive and Gram-negative) as compared to steroidal thiosemicarbazones. Compound Ia displays remarkable antibacterial activity as compared to amoxicillin.

Green synthesis, antibacterial activity and computational study of pyrazoline and pyrimidine derivatives from 3-(3,4-dimethoxy-phenyl-1-(2,5-dimethyl-thiophen-3-yl)-propenone

“…Chloramphenicol (30 mg) was used as the standard drug, whereas a DMSO-wetted disk was used as negative control [40].…”

Kinetic and Mechanism of Oxidation of Methylaminopyrazole Formamidine by Alkaline Hexacyanoferrate(III) and the Effect of Divalent Transition Metal Ions

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“…However when these ligands are coordinated with a metal atom, they show a remarkable biological activities like anti-microbial, anti-viral and anti-tumor etc. [1][2][3]. 1,2,4-Triazine derivatives of Pd (II) and Pt(II) show monodentate and bidentate behavior [4] due to their tautomeric and ambidentate nature.…”