Palladium Nanoparticles/Graphdiyne Oxide Nanocomposite with Excellent Peroxidase-like Activity and Its Application for Glutathione Detection

Lan, Weifei; Hu, Ruifeng; Huang, Danrong; Xu, Dong; Shen, Gangyi; Chang, Shan; Dai, Dongsheng

doi:10.1007/s40242-021-1038-1

Cited by 15 publications

(11 citation statements)

References 41 publications

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“…Wang et al designed a PdFe/glutathione nanocomposite for detecting glutathione in bacteria, which can also efficiently consume glutathione for bacterial disinfection, thus promoting wound healing without significant toxicity both in vivo and in vitro [ 77 ]. Wang et al prepared a Pd/GDYO nanocomposite for the first time and found that the material had significant peroxidase-mimicking activity; based on color changes in the Pd/GDYO-H 2 O 2 -3,3′,5,5′-tetramethylbenzidine reaction, a rapid detection method was established for glutathione in drugs [ 78 ].…”

Section: Applications In Biomedicinementioning

confidence: 99%

Graphdiyne-Related Materials in Biomedical Applications and Their Potential in Peripheral Nerve Tissue Engineering

Jiang

et al. 2022

Cyborg Bionic Syst

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Graphdiyne (GDY) is a new member of the family of carbon-based nanomaterials with hybridized carbon atoms of sp and sp2, including α, β, γ, and (6,6,12)-GDY, which differ in their percentage of acetylene bonds. The unique structure of GDY provides many attractive features, such as uniformly distributed pores, highly π-conjugated structure, high thermal stability, low toxicity, biodegradability, large specific surface area, tunable electrical conductivity, and remarkable thermal conductivity. Therefore, GDY is widely used in energy storage, catalysis, and energy fields, in addition to biomedical fields, such as biosensing, cancer therapy, drug delivery, radiation protection, and tissue engineering. In this review, we first discuss the synthesis of GDY with different shapes, including nanotubes, nanowires, nanowalls, and nanosheets. Second, we present the research progress in the biomedical field in recent years, along with the biodegradability and biocompatibility of GDY based on the existing literature. Subsequently, we present recent research results on the use of nanomaterials in peripheral nerve regeneration (PNR). Based on the wide application of nanomaterials in PNR and the remarkable properties of GDY, we predict the prospects and current challenges of GDY-based materials for PNR.

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Section: Applications In Biomedicinementioning

confidence: 99%

Graphdiyne-Related Materials in Biomedical Applications and Their Potential in Peripheral Nerve Tissue Engineering

Jiang

et al. 2022

Cyborg Bionic Syst

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“…So far, different methods have been used to enhance the catalytic activities of GDY-based nanozymes, such as functional modification and doping heteroatoms. For instance, hemin has been chosen as a functional molecule to improve peroxidase-like activity. − Nanoparticles are also a good choice, such as Pd, PdFe, CeO 2 , and CuS . It has been reported that heteroatoms (N, B, and S) can enhance the enzymatic activity. − Although great efforts have been made to improve the enzymatic activity and the application performance of GDY-based nanozymes, the understanding of their intrinsic properties or their enzyme-mimicking behavior is still limited.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, hemin has been chosen as a functional molecule to improve peroxidase-like activity. 14−16 Nanoparticles are also a good choice, such as Pd, 17 PdFe, 18 CeO 2 , 19 and CuS. 20 It has been reported that heteroatoms (N, B, and S) can enhance the enzymatic activity.…”

Section: Introductionmentioning

confidence: 99%

Graphdiyne Oxide Quantum Dots: The Enhancement of Peroxidase-like Activity and Their Applications in Sensing H₂O₂ and Cysteine

Guo

Huang

Cui

et al. 2022

ACS Appl. Bio Mater.

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As one of the typical carbon nanomaterials, graphdiyne (GDY) with unique chemical, physical, and electronic properties has a great potential in various fields. Although it is an important member of carbon nanozymes, the research on its intrinsic enzyme mimetic properties and applications is still limited. Herein, graphdiyne oxide quantum dots (GDYO QDs) have been synthesized through oxidative cleavage, which exhibit enhanced peroxidase-like activity with lower K m and higher V max than those of most carbon-based nanozymes. The catalytic mechanism is explored, showing that the enhanced catalytic performance is attributed to the good conjugated structure, large number of oxygen-containing groups, and small-sized nanosheets with few layers. As a kind of peroxidase mimetic, the GDY-based nanozyme has excellent potential in sensing H2O2 and biological antioxidants through the colorimetric assay, with a linear range from 5 to 500 μM and detection limit of 1.5 μM for H2O2 and a linear range from 0 to 90 μM and detection limit of 0.48 μM for l-cysteine. Our work will be beneficial to develop high-performance artificial enzymes and to understand their mechanism for better applications.

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“…[36] Another example by Weifei et al utilized graphdiyne oxide loaded with palladium nanoparticles (Pd/GDYO) nanocomposite as a peroxidase mimic to analyze GSH by colori-metric method over a linear range from 0.1 to 40 μM and a limit of detection of 0.1 μM. [37] Rostami et al reported graphene nanoribbons/Ag nanoparticles (GNR/Ag NPs) as a responsive colorimetric sensor for the detection of GSH with a LOD of 1.2 μM. [38] Li et al utilized a hierarchically porous carbon hybrid co-doped with Co and N (Co, N-HPC) as a peroxidase mimic for GSH detection with a linear range of 1-30 μM and a limit of detection of 36 nM.…”

Section: Introductionmentioning

confidence: 99%

“…Another example by Weifei et al. utilized graphdiyne oxide loaded with palladium nanoparticles (Pd/GDYO) nanocomposite as a peroxidase mimic to analyze GSH by colorimetric method over a linear range from 0.1 to 40 μM and a limit of detection of 0.1 μM [37] . Rostami et al.…”

Section: Introductionmentioning

confidence: 99%

A Facile Preparation of Reduced Graphene Oxide Capped AuAg Bimetallic Nanoparticles: A Selective Nanozyme for Glutathione Detection

et al. 2022

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Over the last decade, artificial enzymes (nanozymes) have undergone substantial development in the field of sensing. In this study, Au−Ag bimetallic nanoparticles (NPs) decorated on reduced graphene oxide sheets (AuAg‐rGO) nanocomposite has been developed as a novel colorimetric probe based on the peroxidase imitating activity of the nanozyme. AuAg‐rGO nanocomposite proved to feature an intrinsic peroxidase mimic activity, facilitating the oxidation of a peroxidase substrate like 3,3’,5,5’‐tetramethylbenzidine (TMB) with high efficiency to oxidised TMB (blue coloured product) with the aid of hydrogen peroxide (H2O2). The characteristic Michaelis‐Menten kinetics study allowed the establishment of the catalytic performance of AuAg‐rGO as an artificial enzyme. Glutathione (GSH) displays inhibiting effect on the oxidation of the peroxidase substrate, TMB. Therefore, AuAg‐rGO nanozyme was applied for detection of GSH and exhibited exceptional selectivity and sensitivity with a low limit of detection (LOD) of 38 nM within the 0–200 μM concentration range. The artificial nanozyme system reported here is simple, convenient, and straightforward for colorimetric sensing of GSH.

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Palladium Nanoparticles/Graphdiyne Oxide Nanocomposite with Excellent Peroxidase-like Activity and Its Application for Glutathione Detection

Cited by 15 publications

References 41 publications

Graphdiyne-Related Materials in Biomedical Applications and Their Potential in Peripheral Nerve Tissue Engineering

Graphdiyne-Related Materials in Biomedical Applications and Their Potential in Peripheral Nerve Tissue Engineering

Graphdiyne Oxide Quantum Dots: The Enhancement of Peroxidase-like Activity and Their Applications in Sensing H₂O₂ and Cysteine

A Facile Preparation of Reduced Graphene Oxide Capped AuAg Bimetallic Nanoparticles: A Selective Nanozyme for Glutathione Detection

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Palladium Nanoparticles/Graphdiyne Oxide Nanocomposite with Excellent Peroxidase-like Activity and Its Application for Glutathione Detection

Cited by 15 publications

References 41 publications

Graphdiyne-Related Materials in Biomedical Applications and Their Potential in Peripheral Nerve Tissue Engineering

Graphdiyne-Related Materials in Biomedical Applications and Their Potential in Peripheral Nerve Tissue Engineering

Graphdiyne Oxide Quantum Dots: The Enhancement of Peroxidase-like Activity and Their Applications in Sensing H2O2 and Cysteine

A Facile Preparation of Reduced Graphene Oxide Capped AuAg Bimetallic Nanoparticles: A Selective Nanozyme for Glutathione Detection

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Graphdiyne Oxide Quantum Dots: The Enhancement of Peroxidase-like Activity and Their Applications in Sensing H₂O₂ and Cysteine