Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors

Abstract

New palladium complexes exhibit potent antiproliferative activity against A2780 and cisplatin-resistant A2780C is human ovarian cancer cells.

Building up PtII−Thiosemicarbazone−Lysine−sC18 Conjugates

“…Thiosemicarbazones (TSC) have been studied in the last 70 years with regard to their use as versatile ligands in coordination chemistry [1–17] with applications in transition metal catalysis, [1,4–6] and as materials for biomedical imaging and treatment [5–17] . TSCs of heterocycles, especially pyridine, form a vast group within the class of TSC.…”

“…TSCs of heterocycles, especially pyridine, form a vast group within the class of TSC. They can act as tridentate N^N^Sx chelate ligands forming stable complexes with many metals [1–3] and many studies have shown their cytotoxic behaviour with and without a coordinated metal ion [14–20] …”

DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium

“…Unlike copper, there is no evidence regarding any biological functions of palladium [14]. DNA-binding studies of palladium-based complexes have been investigated [15][16][17][18][19] due to their structural similarities with Pt(II) compounds. Indeed, a square-planar geometry is favored for both metal ions; however, the ligand-exchange kinetics is faster for palladium compounds, generating more reactive compounds that may interact with pharmacological targets in distinct ways [20][21][22].…”

“…In this context, a number of copper(II) and palladium(II) compounds have been investigated as potential DNA binders and/or cleavers [17,18,[23][24][25]. In a previous study, we investigated the DNA-interacting and cytotoxic properties of a dinuclear [Cu(L)Cl 2 ] 2 complex, where L is a Schiff base ligand, namely (E)-phenyl-N-((pyridin-2-yl)methylene)methanamine [26].…”

Synthesis, Characterization of Copper Complexes of 9H-Carbazole-3-carbaldehyde-4-phenylthiosemicarbazone, 10-Hexyl-10-H-phenothiazine-3-carbaldehyde-4-phenylthio semicarbazone and 2-Thiophenecarboxaldehyde-4-methyl- thiosemicarbazone and Anti-bacterial Activity Studies of Ligands and Complexes

“…Among organic reagents, thiosemicarbazones have a vital role due to the ability of formation of bonds with enzymes in biological systems. The donor atoms of nitrogen and sulphur of thiosemicarbazones forms a chelating bonds with the wide range of metal ions [1][2][3][4] . In recent years, so many authors were reported regarding the synthesis and characterization studies of thiosemicarbazones and their metal complexes.…”