Pallidal GABA B receptors: involvement in cortex beta dynamics and thalamic reticular nucleus activity

Villalobos, Nelson; Magdaleno-Madrigal, Víctor Manuel

doi:10.1186/s12576-023-00870-8

Cited by 3 publications

(2 citation statements)

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“…A disinhibitory circuit of the distal dendrites of pyramidal cells mediates motor integration in the somatosensory cortex [64]. Furthermore, it was recently reported that both GAT-1 blockade and GABA B agonism disinhibited the neurons in the reticular thalamic nucleus (RTn) [65,66].…”

Section: Disinhibitionmentioning

confidence: 99%

“…An analysis of the cortical oscillations after GAT-1 blockade demonstrated that high GABA levels influence the beta oscillations related to movement [84]. Moreover, it was recently reported that high GABA levels and the participation of GABA B Rs in the external globus pallidus disinhibit the RTn and thus desynchronize the beta oscillations in the motor cortex [65,66]. In the human visual cortex, the GABA levels modulate the gamma oscillations.…”

Section: Oscillationmentioning

confidence: 99%

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Disinhibition Is an Essential Network Motif Coordinated by GABA Levels and GABA B Receptors

Villalobos

2024

IJMS

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Network dynamics are crucial for action and sensation. Changes in synaptic physiology lead to the reorganization of local microcircuits. Consequently, the functional state of the network impacts the output signal depending on the firing patterns of its units. Networks exhibit steady states in which neurons show various activities, producing many networks with diverse properties. Transitions between network states determine the output signal generated and its functional results. The temporal dynamics of excitation/inhibition allow a shift between states in an operational network. Therefore, a process capable of modulating the dynamics of excitation/inhibition may be functionally important. This process is known as disinhibition. In this review, we describe the effect of GABA levels and GABAB receptors on tonic inhibition, which causes changes (due to disinhibition) in network dynamics, leading to synchronous functional oscillations.

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Section: Disinhibitionmentioning

confidence: 99%

Section: Oscillationmentioning

confidence: 99%

Disinhibition Is an Essential Network Motif Coordinated by GABA Levels and GABA B Receptors

Villalobos

2024

IJMS

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Neural correlates of β-lactam exposure in intensive care unit patients: an observational, prospective cohort study

Zalta,

Trébuchon,

Daquin

et al. 2024

Preprint

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Background: BetaLactam induced neurotoxicity in critical care patients can compromise clinical outcomes. Despite the growing use of therapeutic drug monitoring (TDM) for betalactams, clear toxicity thresholds remain undefined, leaving clinicians uncertain about dosing adjustments when adverse effects occur. Identifying a relevant and easily detectable neurophysiological biomarker for beta-lactam exposure would improve monitoring and prevent serious complications. Methods: In a prospective multicenter, non-interventional study, we analysed electroencephalographic (EEG) signals of 56 patients hospitalized in intensive care units (ICUs) receiving continuous infusions of five betalactams (meropenem, piperacillin/tazobactam, cefepime, cefotaxime, or ceftazidime). We applied a time frequency decomposition on these EEG data to investigate quantitatively the power of neural dynamics across frequencies ranging from 1 to 45 Hz. We used a multivariate pattern decoding method to correlate the betalactam exposure and Sepsis related Organ Failure Assessment (SOFA) scores with the neural activity. Results: betalactam exposure correlated with increased beta to low gamma neural dynamics (20 to 40 Hz) (p < 0.001, FDR corrected), independent of other clinical factors or medications. Beta neural activity was most pronounced in central electrodes (C3 : r = 0.20, p < 0.01; C4 : r = 0.26, p < 0.01) and the right frontal electrode (Fp2 : r = 0.12, p = 0.02). Lower theta to alpha activity (3.5 to 5 Hz and 12 to 18 Hz) was associated with higher SOFA scores (p < 0.001, FDR corrected). No significant correlations were observed between other drugs (opioids, antiseizure medications, psychotropics) and beta or theta to alpha dynamics. Conclusions: These results suggest that beta neural dynamics represent a potential biomarker for betalactam exposure in ICU patients. They highlight the potential of quantitative EEG and advanced multivariate decoding methods to identify subtle neurophysiological features that are otherwise difficult to detect. Trial registration: ClinicalTrials.gov IDNCT03339869. Registered 14 September 2017.

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Functional excitation-inhibition ratio for social anxiety analysis and severity assessment

Chu,

Chau,

Kamel

et al. 2024

Front. Psychiatry

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IntroductionSocial anxiety disorder (SAD) is a prevalent psychiatric condition characterized by an intense fear of and avoidance of social situations. Traditional assessment methods for SAD primarily rely on subjective self-report questionnaires and clinical interviews, which can be prone to biases and inaccuracies. This study aims to explore the functional excitation-inhibition (fEI) ratio derived from EEG data as a potential objective biomarker for assessing SAD severity. MethodsResting-state EEG data were collected from 20 control subjects and 60 individuals with varying degrees of SAD severity (mild, moderate, and severe). The fEI ratio was estimated across different EEG bands and analyzed, focusing on differences between control subjects and SAD groups. ResultsSignificantly higher fEI ratios were observed in the alpha and low beta EEG bands in individuals with SAD compared to controls, especially within the prefrontal cortex. Additionally, a positive correlation was found between the fEI ratio and the severity of social anxiety symptoms across SAD severity levels. DiscussionThe findings indicate that the fEI ratio in the alpha and low beta bands may serve as a promising biomarker for assessing SAD severity. These results contribute to a deeper understanding of the neural mechanisms underlying social anxiety, offering a potentially more objective approach to SAD assessment compared to traditional methods.

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Pallidal GABA B receptors: involvement in cortex beta dynamics and thalamic reticular nucleus activity

Cited by 3 publications

References 94 publications

Disinhibition Is an Essential Network Motif Coordinated by GABA Levels and GABA B Receptors

Disinhibition Is an Essential Network Motif Coordinated by GABA Levels and GABA B Receptors

Neural correlates of β-lactam exposure in intensive care unit patients: an observational, prospective cohort study

Functional excitation-inhibition ratio for social anxiety analysis and severity assessment

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