Palmatine inhibits TRIF-dependent NF-κB pathway against inflammation induced by LPS in goat endometrial epithelial cells

Yan, Baoqi; Wang, Dongsheng; Dong, Shuwei; Cheng, Zhangrui; Na, Lidong; Sang, Mengqi; Yang, Hongzao; Yang, Zhiqiang; Zhang, Shidong; Yan, Zuoting

doi:10.1016/j.intimp.2017.02.004

Cited by 71 publications

(40 citation statements)

References 38 publications

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“…Several studies have also revealed that brauretine can restrain the activation of NF-kB in other cell models or animal models. [65][66][67][68][69] So brauretine from Fibraurea recisa Pierre ameliorate Dgalactose/AlCl 3 -mediated Alzheimer's disease probably by suppressing the NF-kB pathways.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effects and possible molecular mechanisms of action of fibrauretine fromFibraurea recisaPierre ond-galactose/AlCl₃-mediated Alzheimer's disease

Xing

Wang

et al. 2018

RSC Adv.

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Section: Discussionmentioning

confidence: 99%

Ameliorative effects and possible molecular mechanisms of action of fibrauretine fromFibraurea recisaPierre ond-galactose/AlCl₃-mediated Alzheimer's disease

Xing

Wang

et al. 2018

RSC Adv.

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“…In the non Myd88-dependent pathway, TLR4 triggers the activation of the TRIF-related adaptor molecule (TRAM), followed by the activation of interferon regulatory factor 3, which induces the production of IFN-γ. In the later inflammatory response process, TRAM can also activate NF-κB, inducing inflammatory factor expression and activation (Brempelis et al, 2017 ; Yan et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes

Qiao

Chen

et al. 2017

Front. Mol. Neurosci.

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Methamphetamine (METH) is an amphetamine-typed stimulant drug that is increasingly being abused worldwide. Previous studies have shown that METH toxicity is systemic, especially targeting dopaminergic neurons in the central nervous system (CNS). However, the role of neuroinflammation in METH neurotoxicity remains unclear. We hypothesized that Toll-like receptor 4 (TLR4) and Caspase-11 are involved in METH-induced astrocyte-related neuroinflammation. We tested our hypothesis by examining the changes of TLR4 and Caspase-11 protein expression in primary cultured C57BL/6 mouse astrocytes and in the midbrain and striatum of mice exposed to METH with western blot and double immunofluorescence labeling. We also determined the effects of blocking Caspase-11 expression with wedelolactone (a specific inhibitor of Caspase-11) or siRNA on METH-induced neuroinflammation in astrocytes. Furthermore, we determined the effects of blocking TLR4 expression with TAK-242 (a specific inhibitor of TLR4) or siRNA on METH-induced neuroinflammation in astrocytes. METH exposure increased Caspase-11 and TLR4 expression both in vitro and in vivo, with the effects in vitro being dose-dependent. Inhibition of Caspase-11 expression with either wedelolactone or siRNAs reduced the expression of inflammasome NLRP3 and pro-inflammatory cytokines. In addition, blocking TLR4 expression inhibited METH-induced activation of NF-κB and Caspase-11 in vitro and in vivo, suggesting that TLR4-Caspase-11 pathway is involved in METH-induced neuroinflammation. These results indicate that Caspase-11 and TLR4 play an important role in METH-induced neuroinflammation and may be potential gene targets for therapeutics in METH-caused neurotoxicity.

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“…Endometrial epithelial and stromal cells play important roles in uterine inflammation and immunity (Yan et al, ). The present study indicated that LPS can lead to apoptosis, decreased proliferation, autophagy, and inflammation of these cells.…”

Section: Discussionmentioning

confidence: 99%

Endoplasmic reticulum stress is involved in lipopolysaccharide‐induced inflammatory response and apoptosis in goat endometrial stromal cells

Mohamed

Yang

Liu

et al. 2019

Molecular Reproduction Devel

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Endoplasmic reticulum (ER) stress is involved in regulating cell metabolism, apoptosis, autophagy, and survival. However, there is not enough information about the role of ER stress in lipopolysaccharide (LPS)‐induced apoptosis and inflammatory cytokine secretion in the uterus. In this study, we found that LPS induced apoptosis and inflammation in goat endometrial stromal cells (ESCs). LPS treatment inhibited cell viability and cell proliferation. In addition, the genes associated with proliferation, such as proliferating cell nuclear antigen and MKI67, were affected by LPS treatment. Moreover, LPS increased the secretion of interleukin (IL)‐1β and IL‐8, promoting the levels of MYD88, caspase1, and TRL4. The 4‐phenylbutyric acid pretreatment inhibited the expression of unfolded protein response proteins and the secretion of inflammatory cytokines in LPS‐treated cells. However, blockage of inositol‐requiring enzyme 1 and activating transcription factor 6 did not significantly reduce apoptosis and inflammatory cytokine secretion. Collectively, ER stress involved in LPS‐induced apoptosis and inflammatory cytokine increased in goat ESCs. This study provides new insight into the function of ER stress in the pathological process.

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Palmatine inhibits TRIF-dependent NF-κB pathway against inflammation induced by LPS in goat endometrial epithelial cells

Cited by 71 publications

References 38 publications

Ameliorative effects and possible molecular mechanisms of action of fibrauretine fromFibraurea recisaPierre ond-galactose/AlCl₃-mediated Alzheimer's disease

Ameliorative effects and possible molecular mechanisms of action of fibrauretine fromFibraurea recisaPierre ond-galactose/AlCl₃-mediated Alzheimer's disease

Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes

Endoplasmic reticulum stress is involved in lipopolysaccharide‐induced inflammatory response and apoptosis in goat endometrial stromal cells

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Palmatine inhibits TRIF-dependent NF-κB pathway against inflammation induced by LPS in goat endometrial epithelial cells

Cited by 71 publications

References 38 publications

Ameliorative effects and possible molecular mechanisms of action of fibrauretine fromFibraurea recisaPierre ond-galactose/AlCl3-mediated Alzheimer's disease

Ameliorative effects and possible molecular mechanisms of action of fibrauretine fromFibraurea recisaPierre ond-galactose/AlCl3-mediated Alzheimer's disease

Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes

Endoplasmic reticulum stress is involved in lipopolysaccharide‐induced inflammatory response and apoptosis in goat endometrial stromal cells

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Ameliorative effects and possible molecular mechanisms of action of fibrauretine fromFibraurea recisaPierre ond-galactose/AlCl₃-mediated Alzheimer's disease

Ameliorative effects and possible molecular mechanisms of action of fibrauretine fromFibraurea recisaPierre ond-galactose/AlCl₃-mediated Alzheimer's disease